Snx3 Regulates Recycling of the Transferrin Receptor and Iron Assimilation

Sorting of endocytic ligands and receptors is critical for diverse cellular processes. The physiological significance of endosomal sorting proteins in vertebrates, however, remains largely unknown. Here we report that sorting nexin 3 (Snx3) facilitates the recycling of transferrin receptor (Tfrc) and thus is required for the proper delivery of iron to erythroid progenitors. Snx3 is highly expressed in vertebrate hematopoietic tissues. Silencing of Snx3 results in anemia and hemoglobin defects in vertebrates due to impaired transferrin (Tf)-mediated iron uptake and its accumulation in early endosomes. This impaired iron assimilation can be complemented with non-Tf iron chelates. We show that Snx3 and Vps35, a component of the retromer, interact with Tfrc to sort it to the recycling endosomes. Our findings uncover a role of Snx3 in regulating Tfrc recycling, iron homeostasis, and erythropoiesis. Thus, the identification of Snx3 provides a genetic tool for exploring erythropoiesis and disorders of iron metabolism

Tactual perception: a review of experimental variables and procedures

This paper reviews literature on tactual perception. Throughout this review we will highlight some of the most relevant variables in touch literature: interaction between touch and other senses; type of stimuli, from abstract stimuli such as vibrations, to two- and three-dimensional stimuli, also considering concrete stimuli such as the relation between familiar and unfamiliar stimuli or the haptic perception of faces; type of participants, separating studies with blind participants, studies with children and adults, and an analysis of sex differences in performance; and finally, type of tactile exploration, considering conditions of active and passive touch, the relevance of movement in touch and the relation between exploration and time. This review intends to present an organised overview of the main variables in touch experiments, attending to the main findings described in literature, to guide the design of future works on tactual perception and memory.This work was funded by the Portuguese “Foundation for Science and Technology” through PhD scholarship SFRH/BD/35918/2007

Rejoinder to Professor Malawer's Note

The importance of the study of the international legal environment for international business majors cannot be disputed. The only question to be raised is the extent to which international law should be incorporated in every international business student's curriculum (i.e., as a required course or as a portion of one or more existing international business courses). Most textbooks on international business, international marketing, or international management rightly devote at least a chapter to this topic.© 1974 JIBS. Journal of International Business Studies (1974) 5, 85–85

International business transformation patteerns of czech enterprises since the velvet revolution and the velvet divorce

From a macroeconomic standpoint, the Czech Republic has been viewed as a leading example of successful transformation from a state owned to a privatized economy. Yet at the firm and industry levels, the transformation process is still in its early stages. This article focuses on the transformation of outbound international business activities of the country and offers statistical and case study evidence to support four propositions describing the transformation process to date. First, most Czech international business activity is oriented toward its European neighbors. Second, globalization is beginning in a few selected firm and industries. Third, the reliance on low price rather than other international marketing advantages limits the development of world class images of Czech export commodities. Fourth, beginning globalization efforts of Czech firms focus on emerging markets of Asia, South America and Africa and to a lesser extent on the United States but largely exclude Japan.privatization, transformation, globalization, export, industry, price, marketing, competition

OLLI at UNT Podcast

Interview with Dr. James Goodnow for the Osher Lifelong Learning Institute (OLLI) podcast. Susan speaks with him about his work as co-chair of the Day Trippers Special Interest Group. Dr. Goodnow explains the background of this OLLI at UNT group and the types of trips they'll be taking this semester

A Classification of International Business Strategies in the Czech Republic: A Longitudinal Analysis of Selected Firms

This study is focused on relationship between external and internal impact on decision-making influencing international business strategies in transitional economy. Drawing from secondary and primary interview data on international business activities of 18 startups and 20 enterprises operating in the Czech Republic (including firms controlled by both domestic and foreign investors), respectively, the authors propose five strategies. In general, the findings suggest that strategies developed by domestically owned niche-focused or recent startups and those carefully guided by inbound foreign direct investors are more successful. Moreover, the more successful (i.e., those experiencing significant domestic and international sales growth) are those who develop unique marketing strategies. Uncontrollable externalities do not appear to have an impact on firms' success or failure. The regionally oriented exporting tends to be the dominant strategy. Globally oriented export activities are relatively modest whereas outbound direct investment strategies are very minor compared with inbound foreign direct investment activities.transitional economy, international bussiness strategies, foreign direct investors