Settler state apologies and the elusiveness of forgiveness : The purification ritual that does not purify

Peer reviewedPostprin

The Pleiotropic CymR Regulator of Staphylococcus aureus Plays an Important Role in Virulence and Stress Response

We have characterized a novel pleiotropic role for CymR, the master regulator of cysteine metabolism. We show here that CymR plays an important role both in stress response and virulence of Staphylococcus aureus. Genes involved in detoxification processes, including oxidative stress response and metal ion homeostasis, were differentially expressed in a ΔcymR mutant. Deletion of cymR resulted in increased sensitivity to hydrogen peroxide-, disulfide-, tellurite- and copper-induced stresses. Estimation of metabolite pools suggests that this heightened sensitivity could be the result of profound metabolic changes in the ΔcymR mutant, with an increase in the intracellular cysteine pool and hydrogen sulfide formation. Since resistance to oxidative stress within the host organism is important for pathogen survival, we investigated the role of CymR during the infectious process. Our results indicate that the deletion of cymR promotes survival of S. aureus inside macrophages, whereas virulence of the ΔcymR mutant is highly impaired in mice. These data indicate that CymR plays a major role in virulence and adaptation of S. aureus for survival within the host

The first letter of Peter: a global commentary

1 Peter is a significant letter, seen by many scholars to be an ecumenical bridge and anchor. It is first and foremost about the transformative joy of faith in Jesus Christ. This commentary offers a close reading of the text from beginning to end, drawing on a multiplicity of voices and engaging in a number of foundational themes for the Christian community according to the apostolic author: hope, holiness, suffering, joy, witness, hospitality, exile, resurrection, leadership. Tackling the themes raised by the epistle including slavery, exile and refugees, patriarchy, hierarchy, oppression, gender justice, and the risk of hospitality, the book engages with these topics not only through commentary, but also through short excursuses which draw the reader more deeply into some of the difficult questions. Designed as the official commentary resource for the Lambeth 2020 Conference, and structured around the themes of the conference, the book offers a unique range of perspectives on an oft-overlooked epistle. With contributions from an impressive range of contributors including Paula Gooder, Paul Swarup, Emma Ineson, Craig Keener and Kwok Pui Lan, it will provide an important resource for anyone studying, teaching, or preaching from the letter.<p

Public Attitudes to charging for some national health service services

This report describes the views of members of the public to proposals to charge for a given list of NHS services for which no charges are currently made. The questions were part of a survey conducted in Cardiff in 1986. The majority of respondents would agree with the suggested charges being levied. This agreement spanned all sections of society. Despite the majrrity in favour, the sample was divided with a third of respondents being strongly for nearly all the charges and a quarter being strongly against all or all but one of the charges. Most respondents to the survey are judging each charge as a separate issue rather than indicating either approval or disapproval for all cases. If charges for services were to be introduced there could be majority agreement but each charge would have to be considered as a separate issue.charges public opinion survey health services

Screening for glaucoma

Funded by the South and West Regional Health Authority R and D Directorate, Bristol (GB)Available from British Library Document Supply Centre-DSC:3578.772(38) / BLDSC - British Library Document Supply CentreSIGLEGBUnited Kingdo