Methylphenidate and Dextroamphetamine Abuse in Substance-Abusing Adolescents

Sherpa Romeo green journal. Permission to archive accepted author manuscriptThe prevalence of methylphenidate and dextroamphetamine misuse and abuse was examined in 450 adolescents referred for substance abuse treatment. Twenty three percent reported nonmedical use of these substances and six percent were diagnosed as methylphenidate or dextroamphetamine abusers. Abuse was more common in individuals who were out of school and had an eating disorder. Methylphenidate and dextroamphetamine abuse appears to be much less common than abuse of most other substances. It does occur, however, and parents and schools need to exert greater control over the dispensing of these medications. Physicians are advised to prescribe non-stimulant medications (e.g., bupropion) when treating attention deficit hyperactivity disorder in substance-abusing individuals.Ye

Booking clients for addiction treatment: What works best?

Abstract only.A final investigation attempted to determine whether the somewhat lower show-up rates after the Engaged intake could be a result of this procedure actually being therapeutic, thus decreasing the person's distress and need for treatment. This possibility was investigated by examining clinician ratings of the severity of the person's alcohol problems, drug problems and psychological problems when they came in for their assessment.Ye

PPM1D mutations are oncogenic drivers of de novo diffuse midline glioma formation

Abstract The role of PPM1D mutations in de novo gliomagenesis has not been systematically explored. Here we analyze whole genome sequences of 170 pediatric high-grade gliomas and find that truncating mutations in PPM1D that increase the stability of its phosphatase are clonal driver events in 11% of Diffuse Midline Gliomas (DMGs) and are enriched in primary pontine tumors. Through the development of DMG mouse models, we show that PPM1D mutations potentiate gliomagenesis and that PPM1D phosphatase activity is required for in vivo oncogenesis. Finally, we apply integrative phosphoproteomic and functional genomics assays and find that oncogenic effects of PPM1D truncation converge on regulators of cell cycle, DNA damage response, and p53 pathways, revealing therapeutic vulnerabilities including MDM2 inhibition

Merritt Lyndon Fernald correspondence,

Correspondenc