Correction: de Gonzalo, G. Lipase Catalysed Kinetic Resolution of Racemic 1,2-Diols Containing a Chiral Quaternary Center. Molecules 2018, 23, 1585

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Lipase catalysed kinetic resolution of racemic 1,2-diols containing a chiral quaternary center

Optically active 1,2-diols are valuable buildings blocks in organic synthesis. In the present paper, a set of racemic 1,2-diols with an ester functional group are prepared, starting from -ketoesters in a three-step procedure with moderate yields. The racemic 1,2-diols, containing a chiral quaternary center in their structure, are subjected to selective acylation in order to perform their kinetic resolution catalysed by a set of commercially available lipases. Under optimized reaction conditions, good conversions and enantioselectivities are achieved by using the lipase PSL-C from Pseudomonas cepacia in tert-butyl methyl ether. This biocatalyst could be reused up to five times without losing its properties.Ministerio de Economía y Competitividad (contract RYC-2012-10014 for G.d.G., Grants CTQ2016-76908-C2-1-P and CTQ2016-76908-C2-2-P)European FEDER FundsJunta de Andalucía (Grant 2012/FQM 10787