CP violation with a dynamical Higgs

We determine the complete set of independent gauge and gauge-Higgs CP-odd effective operators for the generic case of a dynamical Higgs, up to four derivatives in the chiral expansion. The relation with the linear basis of dimension six CP-odd operators is clarified. Phenomenological applications include bounds inferred from electric dipole moment limits, and from present and future collider data on triple gauge coupling measurements and Higgs signals.Comment: 41 pages, 3 figures; V2: citations added, typos corrected, version published on JHE

The complete HEFT Lagrangian after the LHC Run I

The complete effective chiral Lagrangian for a dynamical Higgs is presented and constrained by means of a global analysis including electroweak precision data together with Higgs and triple gauge-boson coupling data from the LHC Run I. The operators’ basis up to next-to-leading order in the expansion consists of 148 (188 considering righthanded neutrinos) flavour universal terms and it is presented here making explicit the custodial nature of the operators. This effective Lagrangian provides the most general description of the physical Higgs couplings once the electroweak symmetry is assumed, and it allows for deviations from the SU (2)L doublet nature of the Standard Model Higgs. The comparison with the effective linear Lagrangian constructed with an exact SU (2)L doublet Higgs and considering operators with at most canonical dimension six is presented. A promising strategy to disentangle the two descriptions consists in analysing (i) anomalous signals present only in the chiral Lagrangian and not expected in the linear one, that are potentially relevant for LHC searches, and (ii) decorrelation effects between observables that are predicted to be correlated in the linear case and not in the chiral one. The global analysis presented here, which includes several kinematic distributions, is crucial for reducing the allowed parameter space and for controlling the correlations between parameters. This improves previous studies aimed at investigating the Higgs Nature and the origin of the electroweak symmetry breakingI.B. research was supported by an ESR contract of the EU network FP7 ITN INVISIBLES (Marie Curie Actions, PITN-GA-2011-289442).M.C.GG is supported by USA-NSF grant PHY-13-16617, by grants 2014- SGR-104 and by FPA2013-46570 and consolider-ingenio 2010 program CSD-2008-0037. L.M. acknowledge partial support of CiCYT through the project FPA2012-31880 and of the Spanish MINECO’s “Centro de Excelencia Severo Ochoa” Programme under grant SEV- 2012-0249. M.C.G-G and L.M. acknowledge partial support by FP7 ITN INVISIBLES (PITN-GA-2011-289442), FP10 ITN ELUSIVES (H2020-MSCA-ITN-2015-674896) and INVISIBLES-PLUS (H2020- MSCA-RISE-2015-690575

Disentangling a dynamical Higgs

The pattern of deviations from Standard Model predictions and couplings is different for theories of new physics based on a non-linear realization of the $SU(2)_L\times U(1)_Y$ gauge symmetry breaking and those assuming a linear realization. We clarify this issue in a model-independent way via its effective Lagrangian formulation in the presence of a light Higgs particle, up to first order in the expansions: dimension-six operators for the linear expansion and four derivatives for the non-linear one. Complete sets of pure gauge and gauge-Higgs operators are considered, implementing the renormalization procedure and deriving the Feynman rules for the non-linear expansion. We establish the theoretical relation and the differences in physics impact between the two expansions. Promising discriminating signals include the decorrelation in the non-linear case of signals correlated in the linear one: some pure gauge versus gauge-Higgs couplings and also between couplings with the same number of Higgs legs. Furthermore, anomalous signals expected at first order in the non-linear realization may appear only at higher orders of the linear one, and vice versa. We analyze in detail the impact of both type of discriminating signals on LHC physics.Comment: Version published in JHE

Higgs ultraviolet softening

We analyze the leading effective operators which induce a quartic momentum dependence in the Higgs propagator, for a linear and for a non-linear realization of electroweak symmetry breaking. Their specific study is relevant for the understanding of the ultraviolet sensitivity to new physics. Two methods of analysis are applied, trading the Lagrangian coupling by: i) a "ghost" scalar, after the Lee-Wick procedure; ii) other effective operators via the equations of motion. The two paths are shown to lead to the same effective Lagrangian at first order in the operator coefficients. It follows a modification of the Higgs potential and of the fermionic couplings in the linear realization, while in the non-linear one anomalous quartic gauge couplings, Higgs-gauge couplings and gauge-fermion interactions are induced in addition. Finally, all LHC Higgs and other data presently available are used to constrain the operator coefficients; the future impact of $pp\to\text{4 leptons}$ data via off-shell Higgs exchange and of vector boson fusion data is considered as well. For completeness, a summary of pure-gauge and gauge-Higgs signals exclusive to non-linear dynamics at leading-order is included.Comment: 31 pages, 3 figures, 7 table

Autophagy Regulates the Liver Clock and Glucose Metabolism by Degrading CRY1

The circadian clock coordinates behavioral and circadian cues with availability and utilization of nutrients. Proteasomal degradation of clock repressors, such as cryptochrome (CRY) 1, maintains periodicity. Whether macroautophagy, a quality control pathway, degrades circadian proteins remains unknown. Here we show that circadian proteins BMAL1, CLOCK, REV-ERB alpha, and CRY1 are lysosomal targets, and that macroautophagy affects the circadian clock by selectively degrading CRY1. Autophagic degradation of CRY1, an inhibitor of gluconeogenesis, occurs in a diurnal window when rodents rely on gluconeogenesis, suggesting that CRY1 degradation is timeimprinted to maintenance of blood glucose. High-fat feeding accelerates autophagic CRY1 degradation and contributes to obesity-associated hyperglycemia. CRY1 contains several light chain 3 (LC3)-interacting region (LIR) motifs, which facilitate the interaction of cargo proteins with the autophagosome marker LC3. Using mutational analyses, we identified two distinct LIRs on CRY1 that exert circadian glycemic control by regulating CRY1 degradation, revealing LIRs as potential targets for controlling hyperglycemia.Peer reviewe

Towards Minimal S4 Lepton Flavor Model

We study lepton flavor models with the $S_4$ flavor symmetry. We construct simple models with smaller numbers of flavon fields and free parameters, such that we have predictions among lepton masses and mixing angles. The model with a $S_4$ triplet flavon is not realistic, but we can construct realistic models with two triplet flavons, or one triplet and one doublet flavons.Comment: 18 pages, 4 figures, references are adde

Discrete symmetries and models of flavor mixing

Evidences of a discrete symmetry behind the pattern of lepton mixing are analyzed. The program of "symmetry building" is outlined. Generic features and problems of realization of this program in consistent gauge models are formulated. The key issues include the flavor symmetry breaking, connection of mixing and masses, {\it ad hoc} prescription of flavor charges, "missing" representations, existence of new particles, possible accidental character of the TBM mixing. Various ways are considered to extend the leptonic symmetries to the quark sector and to reconcile them with Grand Unification. In this connection the quark-lepton complementarity could be a viable alternative to TBM. Observational consequences of the symmetries and future experimental tests of their existence are discussed.Comment: 14 pages, 5 figures. Talk given at the Symposium "DISCRETE 2010", 6 - 11 December 2010, La Sapienza, Rome, Ital

Computational Cancer Biology: An Evolutionary Perspective

ISSN:1553-734XISSN:1553-735