Evaluación de PGPB halotolerantes/halófilas en grama rhodes (chloris gayana) bajo estrés salinoo

Poster y resumenLas bacterias promotoras de crecimiento vegetal (PGPB), en particular aquellas halotolerantes o halófilas, constituyen una alternativa prometedora para mitigar los efectos de la salinidad e incrementar la tolerancia al estrés de las plantas. Su aplicación en pasturas megatérmicas como Grama Rhodes resulta estratégica, dada su importancia en la ganadería Argentina, su baja eficiencia de implantación y su siembra en zonas áridas y degradadas.Fil: Yañez Yazlle, María Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Unidad de Estudios Agropecuarios (UDEA); ArgentinaFil: Yañez Yazlle, María Florencia. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Fisiología y Recursos Genéticos Vegetales; ArgentinaFil: Ribotta, Andrea Noemi. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Fisiología y Recursos Genéticos Vegetales; ArgentinaFil: Ribotta, Andrea Noemi. Consejo Nacional de Investigaciones Científicas y Técnicas. Unidad de Estudios Agropecuarios (UDEA); ArgentinaFil: Lopez Colomba, Eliana. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Fisiología y Recursos Genéticos Vegetales; ArgentinaFil: Lopez Colomba, Eliana. Consejo Nacional de Investigaciones Científicas y Técnicas. Unidad de Estudios Agropecuarios (UDEA); ArgentinaFil: Irazusta, V. Universidad Nacional de Salta. Instituto de Investigaciones para la Industria Química (INIQUI). Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET); ArgentinaFil: Gonzalez, M. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas; ArgentinaFil: Grunberg, Karina. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Fisiología y Recursos Genéticos Vegetales; ArgentinaFil: Grunberg, Karina. Consejo Nacional de Investigaciones Científicas y Técnicas. Unidad de Estudios Agropecuarios (UDEA); Argentin

Fundamental frequency in transsexual men in different stages of hormonal treatment

El tratamiento hormonal que reciben los hombres transexuales tiene entre sus efectos la masculinización de la voz. El objetivo de esta investigación es medir la mediana de la frecuencia fundamental en el habla (Mf0) en hombres transexuales en distintas etapas de su tratamiento hormonal y determinar el nivel de correlación entre este parámetro y el número de dosis recibidas. Utilizando Praat se obtuvo el valor de la Mf0 de una serie automática de palabras, su valor mínimo y máximo, y el rango. Se separó la muestra en dos grupos según el número de dosis de hormonas recibidas. El Grupo 1 estuvo conformado por sujetos con 11 o menos dosis de testosterona. El Grupo 2 estuvo conformado por sujetos con 12 o más dosis. Los valores encontrados son comparables con los esperados para hombres no transgéneros. No se encontraron diferencias significativas respecto a la Mf0, Mf0min, Mf0máx y rango, al comparar los grupos 1 y 2. Existe una correlación baja entre el número de dosis y la Mf0. Existe una asociación entre el tratamiento hormonal y la masculinización de la voz, sin embargo, no existe evidencia que señale que a mayor número de dosis de hormonas exista una mayor masculinización de la voz. Se necesita realizar nuevas investigaciones con población más grande para verificar estos resultados.The hormonal treatment that transsexual men receive has among its effects the masculinization of the voice. The objective of this research is to measure the median fundamental frequency in speech (Mf0) in transsexual men at different stages of their hormonal treatment and to determine the level of correlation between this parameter and the number of doses received. Using Praat, the Mf0 value of an automatic series of words, its minimum, maximum and range values was obtained. The sample was separated into two groups according to the number of doses of hormones received. Group 1 consisted of subjects with 11 or less doses of testosterone. Group 2 was made up of subjects with 12 or more doses. The values found are comparable with those expected for non-transgender men. No significant differences were found with respect to Mf0, Mf0min, Mf0max and range, when comparing groups 1 and 2. There is a low correlation between the number of doses and Mf0. There is an association between hormonal treatment and masculinization of the voice, however, there is no evidence to indicate that the higher the number of doses of hormones there is a greater masculinization of the voice. New research with a larger population is needed to verify these results

Global variation in postoperative mortality and complications after cancer surgery: a multicentre, prospective cohort study in 82 countries

© 2021 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 licenseBackground: 80% of individuals with cancer will require a surgical procedure, yet little comparative data exist on early outcomes in low-income and middle-income countries (LMICs). We compared postoperative outcomes in breast, colorectal, and gastric cancer surgery in hospitals worldwide, focusing on the effect of disease stage and complications on postoperative mortality. Methods: This was a multicentre, international prospective cohort study of consecutive adult patients undergoing surgery for primary breast, colorectal, or gastric cancer requiring a skin incision done under general or neuraxial anaesthesia. The primary outcome was death or major complication within 30 days of surgery. Multilevel logistic regression determined relationships within three-level nested models of patients within hospitals and countries. Hospital-level infrastructure effects were explored with three-way mediation analyses. This study was registered with ClinicalTrials.gov, NCT03471494. Findings: Between April 1, 2018, and Jan 31, 2019, we enrolled 15 958 patients from 428 hospitals in 82 countries (high income 9106 patients, 31 countries; upper-middle income 2721 patients, 23 countries; or lower-middle income 4131 patients, 28 countries). Patients in LMICs presented with more advanced disease compared with patients in high-income countries. 30-day mortality was higher for gastric cancer in low-income or lower-middle-income countries (adjusted odds ratio 3·72, 95% CI 1·70–8·16) and for colorectal cancer in low-income or lower-middle-income countries (4·59, 2·39–8·80) and upper-middle-income countries (2·06, 1·11–3·83). No difference in 30-day mortality was seen in breast cancer. The proportion of patients who died after a major complication was greatest in low-income or lower-middle-income countries (6·15, 3·26–11·59) and upper-middle-income countries (3·89, 2·08–7·29). Postoperative death after complications was partly explained by patient factors (60%) and partly by hospital or country (40%). The absence of consistently available postoperative care facilities was associated with seven to 10 more deaths per 100 major complications in LMICs. Cancer stage alone explained little of the early variation in mortality or postoperative complications. Interpretation: Higher levels of mortality after cancer surgery in LMICs was not fully explained by later presentation of disease. The capacity to rescue patients from surgical complications is a tangible opportunity for meaningful intervention. Early death after cancer surgery might be reduced by policies focusing on strengthening perioperative care systems to detect and intervene in common complications. Funding: National Institute for Health Research Global Health Research Unit

Effects of hospital facilities on patient outcomes after cancer surgery: an international, prospective, observational study

© 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 licenseBackground: Early death after cancer surgery is higher in low-income and middle-income countries (LMICs) compared with in high-income countries, yet the impact of facility characteristics on early postoperative outcomes is unknown. The aim of this study was to examine the association between hospital infrastructure, resource availability, and processes on early outcomes after cancer surgery worldwide. Methods: A multimethods analysis was performed as part of the GlobalSurg 3 study—a multicentre, international, prospective cohort study of patients who had surgery for breast, colorectal, or gastric cancer. The primary outcomes were 30-day mortality and 30-day major complication rates. Potentially beneficial hospital facilities were identified by variable selection to select those associated with 30-day mortality. Adjusted outcomes were determined using generalised estimating equations to account for patient characteristics and country-income group, with population stratification by hospital. Findings: Between April 1, 2018, and April 23, 2019, facility-level data were collected for 9685 patients across 238 hospitals in 66 countries (91 hospitals in 20 high-income countries; 57 hospitals in 19 upper-middle-income countries; and 90 hospitals in 27 low-income to lower-middle-income countries). The availability of five hospital facilities was inversely associated with mortality: ultrasound, CT scanner, critical care unit, opioid analgesia, and oncologist. After adjustment for case-mix and country income group, hospitals with three or fewer of these facilities (62 hospitals, 1294 patients) had higher mortality compared with those with four or five (adjusted odds ratio [OR] 3·85 [95% CI 2·58–5·75]; p<0·0001), with excess mortality predominantly explained by a limited capacity to rescue following the development of major complications (63·0% vs 82·7%; OR 0·35 [0·23–0·53]; p<0·0001). Across LMICs, improvements in hospital facilities would prevent one to three deaths for every 100 patients undergoing surgery for cancer. Interpretation: Hospitals with higher levels of infrastructure and resources have better outcomes after cancer surgery, independent of country income. Without urgent strengthening of hospital infrastructure and resources, the reductions in cancer-associated mortality associated with improved access will not be realised. Funding: National Institute for Health and Care Research