Pseudoscalar Meson and Charmed Baryon Scattering Lengths

We have calculated the scattering lengths between the pseudoscalar meson and charmed triplet, sextet, and excited sextet baryon to the third order with the heavy baryon chiral perturbation theory. The chiral expansion of the pion channels converges well.Comment: 14 pages, 1 figure, 4 tables; discussion extended, references added, version published in Phys. Rev. D; typos removed from Eqs. (B2, B5, B6, 19), erratum corrected in Eq. (B6), tables (I, II, III) update

Efficient Commercial Bank Customer Credit Risk Assessment Based on LightGBM and Feature Engineering

Effective control of credit risk is a key link in the steady operation of commercial banks. This paper is mainly based on the customer information dataset of a foreign commercial bank in Kaggle, and we use LightGBM algorithm to build a classifier to classify customers, to help the bank judge the possibility of customer credit default. This paper mainly deals with characteristic engineering, such as missing value processing, coding, imbalanced samples, etc., which greatly improves the machine learning effect. The main innovation of this paper is to construct new feature attributes on the basis of the original dataset so that the accuracy of the classifier reaches 0.734, and the AUC reaches 0.772, which is more than many classifiers based on the same dataset. The model can provide some reference for commercial banks' credit granting, and also provide some feature processing ideas for other similar studies

The Pseudoscalar Meson and Heavy Vector Meson Scattering Lengths

We have systematically studied the S-wave pseudoscalar meson and heavy vector meson scattering lengths to the third order with the chiral perturbation theory, which will be helpful to reveal their strong interaction. For comparison, we have presented the numerical results of the scattering lengths (1) in the framework of the heavy meson chiral perturbation theory and (2) in the framework of the infrared regularization. The chiral expansion converges well in some channels.Comment: 10 pages, 1 figures, 4 tables. Corrected typos, Improved numerical results, and More dicussions. Accepted for publication by Phys.Rev.

Screening of patients with tuberculosis for diabetes mellitus in China.

Objective  There is a high burden of both diabetes (DM) and tuberculosis (TB) in China, and this study aimed to assess feasibility and results of screening patients with TB for DM within the routine healthcare setting of six health facilities. Method  Agreement on how to screen, monitor and record was reached in May 2011 at a stakeholders' meeting, and training was carried out for staff in the six facilities in July 2011. Implementation started in September 2011, and we report on 7 months of activities up to 31 March 2012. Results  There were 8886 registered patients with TB. They were first asked whether they had DM. If the answer was no, they were screened with a random blood glucose (RBG) followed by fasting blood glucose (FBG) in those with RBG ≥ 6.1 mm (one facility) or with an initial FBG (five facilities). Those with FBG ≥ 7.0 mm were referred to DM clinics for diagnostic confirmation with a second FBG. Altogether, 1090 (12.4%) patients with DM were identified, of whom 863 (9.7%) had a known diagnosis of DM. Of 8023 patients who needed screening for DM, 7947 (99%) were screened. This resulted in a new diagnosis of DM in 227 patients (2.9% of screened patients), and of these, 226 were enrolled to DM care. In addition, 575 (7.8%) persons had impaired fasting glucose (FBG 6.1 to <7.0 mm). Prevalence of DM was significantly higher in patients in health facilities serving urban populations (14.0%) than rural populations (10.6%) and higher in hospital patients (13.5%) than those attending TB clinics (8.5%). Conclusion  This pilot project shows that it is feasible to screen patients with TB for DM in the routine setting, resulting in a high yield of patients with known and newly diagnosed disease. Free blood tests for glucose measurement and integration of TB and DM services may improve the diagnosis and management of dually affected patients

Neuroimaging anomalies in asymptomatic middle cerebral artery steno-occlusive disease with normal-appearing white matter

BackgroundAsymptomatic chronic cerebrovascular steno-occlusive disease is common, but the cognitive function and alterations in the brain’s structural and functional profiles have not been well studied. This study aimed to reveal whether and how patients with asymptomatic middle cerebral artery (MCA) steno-occlusive disease and normal-appearing white matter differ in brain structural and functional profiles from normal controls and their correlations with cognitive function.MethodsIn all, 26 patients with asymptomatic MCA steno-occlusive disease and 22 healthy controls were compared for neurobehavioral assessments, brain volume, cortical thickness, fiber connectivity density (FiCD) value, and resting-state functional connectivity (FC) using multimodal MRI. We also investigated the associations between abnormal cortical thicknesses, FiCD values, and functional connectivities with the neurobehavioral assessments.ResultsPatients performed worse on memory tasks (Auditory Verbal Learning Test-Huashan version) compared with healthy controls. Patients were divided into two groups: the right group (patients with right MCA steno-occlusive disease) and the left group (patients with left MCA steno-occlusive disease). The left group showed significant cortical thinning in the left superior parietal lobule, while the right group showed significant cortical thinning in the right superior parietal lobule and caudal portion of the right middle frontal gyrus. Increased FiCD values in the superior frontal region of the left hemisphere were observed in the left group. In addition, a set of interhemispheric and intrahemispheric FC showed a significant decrease or increase in both the left and right groups. Many functional connectivity profiles were positively correlated with cognitive scores. No correlation was found between cortical thickness, FiCD values, and cognitive scores.ConclusionEven if the patients with MCA steno-occlusive disease were asymptomatic and had normal-appearing white matter, their cognitive function and structural and functional profiles had changed, especially the FC. Alterations in FC may be an important mechanism underlying the neurodegenerative process in patients with asymptomatic MCA steno-occlusive disease before structural changes occur, so FC assessment may promote the detection of network alterations, which may be used as a biomarker of disease progression and therapeutic efficacy evaluation in these patients

Ethyl ent-15α-[(2-meth­oxy­benz­yloxy)meth­yl]-16-oxobeyeran-20-oate

The title compound, C31H44O5, was synthesized from isostev­iol (systematic name: ent-16-ketobeyeran-19-oic acid). In the mol­ecule, the three six-membered rings adopt chair conformations and the stereochemistry of the A/B and B/C ring junctions are trans. The five-membered ring D adopts an envelope conformation with the methyl­ene C atom as the flap

PO-162 ELABELA Facilitates Exercise-Induced Cardioprotection in Post-Infarction Cardiac Remodeling

Objective Exercise has been reported to have positive function after myocardial infarction (MI), but the mechanisms of exercise-induced cardioprotection are poorly understood. ELABELA (ELA) is a hormone and plays a vital role in cardiovascular system. The aim of this research is to investigate the effect and the mechanisms of exercise and exogenous ELA administration on cardioprotection in MI rat. Methods MI was established by left coronary artery ligation. MI rats underwent 4 weeks of sustainedaerobic exercise and Fc-ELA-21 or Fc-ELA-32 injection. H9C2 cells were treated by ELA-14 peptide. Akt signal was inhibited by LY294002. Heart function was evaluated by hemodynamics; Myocardium fibrosis, cell proliferation, angiogenesis and apoptosis were visualized by Masson’s staining, immunohistochemistry and TUNEL, respectively; Protein expression was quantified by Western blotting. Results Exercise induced angiogenesis and cardiomyocyte proliferation, reduced fibrosis and improved the function of MI heart. Fc-ELA-21 injection further facilitated the exercise-induced cardioprotection effects. APJ expression was up-regulated and Akt-mTOR-P70S6K signal was activated by both exercise and Fc-ELA-21. In H9C2 cells, ELA-14 activated Akt signal by dose dependent manner. Akt signal inhibitioninvalidated ELA-14 function. Fc-ELA-32 directly improved structural and functional recovery of post-MI hearts. Conclusions ELA is a heart protector and facilitates exercise-induced cardioprotectionthrough Akt-mTOR-P70S6K signal inpost-infarction cardiac remodeling