3 research outputs found
The Use Of Inner Tube In Orthopaedic Surgery: Applications, Advantages And Disadvantages [uso Da Câmara De Ar Em Cirurgia Ortopédica: Aplicações, Vantagens E Desvantagens]
Objective: this paper aimed at promoting the use of the inner tube as a systematic device in orthopedic surgery, such as body holder and protector of bony projections, especially in long-term spine surgeries. Methods: this was a prospective non-randomized study, carried out from 2002 to 2007, with 264 orthopedic procedures. Results: we found that, regardless the time of surgery, there were no areas of pressure around bony prominences or injury of peripheral nerves in the postoperative follow-up. Conclusion: those results could recommend the inner tube as an excellent option like a frame in orthopedic surgery. It is an inexpensive device, easy to obtain, and without known complications.84408411Mouradian, H.M., Simmons, E.H., A frame for spinal surgery to reduce intra-abdominal pressure while continuous traction is applied (1977) J Bone Joint Surg Am, 59 (8), pp. 1098-1099Kumar, S.J., Torres, B.C., Borges, J.L., Quinn, T., A radiolucent spine frame: A modification of the Relton-Hall spine frame (1994) J Pediatr Orthop, 14 (3), pp. 383-384Mirovsky, Y., Neuwirth, M., Michael, M.D., Injuries to the lateral femoral cutaneous nerve during spine surgery (2000) Spine (Phila Pa 1976), 25 (10), pp. 1266-1269Yang, S.H., Wu, C.C., Chen, P.Q., Postoperative meralgia paresthetica after posterior spine surgery: Incidence, risk factors, and clinical outcomes (2005) Spine, 15-30 (18), pp. 547-550Barclay, L., Nghiem, H.T., Meralgia paresthetica may complicate posterior spine surgery CME (2005) Spine, 30, pp. E547-E550Schwartz, D.M., Drummond, D.S., Hahn, M., Ecker, M.L., Dormans, J.P., Prevention of positional brachial plexopathy during surgical correction of scoliosis (2000) J Spinal Disord, 13 (2), pp. 178-182Rigamonti, A., Gemma, M., Rocca, A., Messina, M., Bignami, E., Beretta, L., Prone versus knee-chest position for microdiscectomy: A prospective randomized study of intra-abdominal pressure and intraoperative bleeding (2005) Spine (Phila Pa 1976), 30 (17), pp. 1918-1923Relton, J.E., Hall, J.E., An operation frame for spinal fusion. A new apparatus designed to reduce haemorrhage during operation (1967) J Bone Joint Surg Br, 49 (2), pp. 327-332Gupta, A., Muzumdar, D., Ramani, P.S., Meralgia paraesthetica following lumbar spine surgery: A study in 110 consecutive surgically treated cases (2004) Neurol India, 52 (1), pp. 64-6
Vascular Pattern In Enchondroma And Chondrosarcoma: Clinical And Immunohistologic Study
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Introduction: Although cartilaginous tumors have low microvascular density, vessels are important for the provision of nutrition so that the tumor can grow and generate metastasis. The aim of this study was to assess the value of the vascular pattern classification as a prognostic tool in chondrosarcomas (CSs) and its relation with vascular endothelial growth factor (VEGF) expression.Materials and Methods: This was a retrospective study of 21 enchondromas and 57 conventional CSs. Clinical data and outcome were retrieved from medical files. CSs histologic grades (on a scale of 1 to 3) were determined according to the World Health Organization classification. The vascular pattern (on a scale of A to C) was assessed through CD34, according to Kalinski. CD105 and VEGF were also evaluated.Results: Poor outcome was significantly associated with vascular pattern groups B and C. Higher vascular pattern were 6.5 times more frequent in moderate-grade and high-grade CSs than in grade 1 CS. On multivariate analysis, a clear correlation was found between VEGF overexpression and B/C vascular patterns. Only 18 (benign and malignant) tumors stained for CD105.Discussion: The results point to the use of the vascular pattern classification as a prognostic tool in CSs and to differentiate low-grade from moderate-grade/high-grade CSs. Vascular pattern might be also used to complement histologic grade, VEGF immunostaining, and microvascular density, for indicating a patient's prognosis. Low-grade CSs develop under low neoangiogenesis, which conforms to the slow growth rate of these tumors.228600605FAPESP; São Paulo Research FoundationFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Grifone, T.J., Haupt, H.M., Podolski, V., Immunohistochemical expression of estrogen receptors in chondrosarcomas and enchondromas (2008) Int J Surg Pathol, 16, pp. 31-37Reliability of histopathologic and radiologic grading of cartilaginous neoplasms in long bones (2007) J Bone Joint Surg Am, 89, pp. 2113-2123Kalinski, T., Roessner, A., Angiogenesis in cartilage tumors (2010) Pathologe, 31, pp. 177-182Folkman, J., Tumor angiogenesis (1985) Adv Cancer Res, 43, pp. 175-203Dvorak, H.F., Brown, L.F., Detmar, M., Vascular permeability factor/vascular endothelial growth factor, microvascular hipermeability and angiogenesis (1995) Am J Pathol, 146, pp. 1029-1039McGough, R., Aswad, B., Terek, R.M., Pathologic neovascularization in cartilage tumors (2002) Clin Orthop Relat Res, 397, pp. 76-82Terek, R.M., Angiogenesis in chondrosarcoma (2002) Curr Opin Orthop, 13, pp. 449-453Mayrogenesis, A.F., Gambarotti, M., Angelini, A., Chondrosarcoma revisited (2012) Orthopedics, 35, pp. 379-390Amstalden, E.M.I., Tumores do sistema osteoarticular (2004) Patologia Diagnostica de Tumores, pp. 345-352. , Billis A, Vassalo J, eds., 2nd ed. Campinas, Brazil: Impressão Digital do Brasil Grá fica e EditoraMurata, M., Yudoh, K., Masuko, K., The potential role of vascular endothelial growth factor (vegf) in cartilage: How the angiogenic factor could be involved in the pathogenesis of osteoarthritis? (2008) Osteoarthritis Cartilage, 16, pp. 279-286Ayala, G., Lui, C., Nicosia, R., Microvasculature and vegf expression in cartilaginous tumors (2000) Hum Pathol, 31, pp. 341-346Kalinski, T., Krueger, S., Sel, S., Differential expression of vegfa and angiopoetins in cartilage tumors and regulation by interleukin-1b (2006) Cancer, 106, pp. 2028-2038Falcone, G., Rossi, E.D., Maccauro, G., Diagnostic relevance of the immunohistochemical detection of growth factors in benign and malignant cartilaginous tumors (2006) Appl Immunohistochem Mol Morphol, 14, pp. 334-340Sutton, K.M., Wright, M., Fondren, G., Cyclooxygenase-2 expression in chondrosarcoma (2004) Oncology, 66, pp. 275-280Endo, M., Matsumura, T., Yamaguchi, T., Cycloxygenase-2 overexpression associated with a poor prognosis in chondrosarcomas (2006) Hum Pathol, 37, pp. 471-476Schrage, Y.M., Machado, I., Meijer, D., COX-2 expression in chondrosarcoma: A role for celecoxib treatment? (2010) Eur J Cancer, 46, pp. 616-624Nakagawa, S.A., Lopes, A., Lopes De Carvalho, A., Nitric oxide synthase, cycloxigenase-2, nitrotyrosine, and angiogenesis in chondrosarcoma and their relation to prognosis (2010) Bone Joint Surg Am, 92, pp. 1738-1746Kalinski, T., Sel, S., Kouznetsova, I., Heterogeneity of angiogenesis and blood vessel maturation in cartilage tumors (2009) Pathol Res Pract, 205, pp. 339-345Wang, X.L., De Beuckeleer, L.H., De Schepper, A.M., Low-grade chondrosarcoma vs enchondroma: Challenges in diagnosis and management (2001) Eur Radiol, 11, pp. 1054-1057Weiner, S.D., Enchondroma and chondrosarcoma of bone: Clinical, radiologic, and histologic differentiation (2004) Instr Course Lect, 53, pp. 645-649Santacreu, E.M.F., Cruz, E.J.O., López, J.M.G., Enchondorma verus low-grade chondrosarcoma in apendicular skeleton: Clinical anda radiological criteria (2012) J Oncol, 2012, p. 437958Dorfman, H.D., Czerniak, B., Bone cancers (1995) Cancer, 75, pp. 203-210Krause, D.S., Fackler, M.J., Civin, C.I., CD34: Structure, biology, and clinical utility (1996) Blood, 87, pp. 1-13Lindenmayer, A.E., Miettinen, M., Immunophenotypic features of uterine stromal cells. Cd34 expression in endocervical stroma (1995) Virchows Arch, 426, pp. 457-460Fina, L., Molgaard, H.V., Robertson, D., Expression of the cd34 gene in vascular endothelial cells (1990) Blood, 15, pp. 2417-2426Brekken, R.A., Li, C., Kumar, S., Strategies for vascular targeting in tumors (2002) Int J Cancer, 100, pp. 123-130Sanchez-Elsner, T., Botella, L.M., Velasco, B., Endoglin expression is regulated by transcriptional cooperation between the hypoxia and transformin growth factor-beta pathways (2002) J Biol Chem, 277, pp. 43799-43808Kumar, S., Ghellal, A., Li, C., Breast carcinoma: Vascular density determined using cd105 antibody correlates with tumor prognosis (1999) Cancer Res, 59, pp. 856-861Minhajat, R., Mori, D., Yamasaki, F., Endoglin (cd105) expression in angiogenesis of colon cancer: Analysis using tissue microarrays and comparison with other endothelial markers (2006) Virchows Arch, 44, pp. 127-134Sharma, S., Sharma, M.C., Sarkar, C., Morphology of angiogenesis in human cancer: A conceptual overview, histoprognostic perspective and significance of neoangiogenesis (2005) Histopathology, 46, pp. 481-489Hillen, F., Griffioen, A.W., Tumor vascularization: Sprouting angiogenesis and beyond (2007) Cancer Metastasis Rev, 26, pp. 489-502Cintra, F.F., Cassone, A.E., Gonçalves, J.C.B., Prognostic significance of cyclooxygenase-2 (cox-2) expression in cartilaginous tumors (2010) Histopathology, 57, p. 20Giuffrida, A.Y., Burgueno, J.E., Koniaris, L.G., Chondrosarcoma in the united states (1973 to 2003): An analysis of 2890 cases from the seer database (2009) J Bone Joint Surg Am, 91, pp. 1063-1072Chow, W.A., Update on chondrosarcomas (2007) Curr Opin Oncol, 19, pp. 371-376Cintra, F.F., (2012) Análise de Fatores Angiogênicos e da Expressão da COX- 2 em Tumores de Linhagem Cartilaginosa-Correlação Clínica e Histológica [Tese-Doutorado], , Campinas SP: Universidade Estadual e CampinasStepanova, E.V., Kharatishvili, T.K., Lichnitser, M.R., Prognostic significance of p53, her-2/neu, ki-67 and vegf expression in chondrosarcomas (2002) Arkh Patol, 64, pp. 9-12Fonsatti, E., Sigalotti, L., Arslan, P., Emerging role of endoglin (cd105) as a marker of angiogenesis with clinical potential in human malignancies (2003) Curr Cancer Drug Targets, 3, pp. 427-432Postiglione, L., Di Domenico, G., Caraglia, M., Differential expression and cytoplasm/membrane distribution of endoglin (cd105) in human tumour cell lines: Implications in the modulation of cell proliferation (2005) Int J Oncol, 26, pp. 1193-1201Luque, A., Slevin, M., Turu, M.M., CD105 positive neovessels are prevalent in early stage carotid lesions, and correlate with the grade in more advanced carotid and coronary plaques (2009) J Angiogenes Res, 1, pp. 6-16Manor, E., Kachko, L., Puterman, M.B., Cystic lesions of the jaws - A clinicopathological study of 322 cases and review of the literature (2006) J Med Sci, 9, pp. 20-26Yamamoto, F.P., (2010) Estudo da Presença de Osteonecrose Na Mandíbula Após Exodontia de Molares em Ratos Tratados Com Alendronato de Sódio [Tese-Doutorado], , São Paulo: Universidade de São Paul