Natural Products Chemistry and Taxonomy of the Marine Cyanobacterium Blennothrix cantharidosmum

A Papua New Guinea field collection of the marine cyanobacterium Blennothrix cantharidosmum was investigated for its cytotoxic constituents. Bioassay-guided isolation defined the cytotoxic components as the known compounds lyngbyastatins 1 and 3. However, six new acyl proline derivatives, tumonoic acids D−I, plus the known tumonoic acid A were also isolated. Their planar structures were defined from NMR and MS data, while their stereostructures followed from a series of chiral chromatographies, degradation sequences, and synthetic approaches. The new compounds were tested in an array of assays, but showed only modest antimalarial and inhibition of quorum sensing activities. Nevertheless, these are the first natural products to be reported from this genus, and this inspired a detailed morphologic and 16S rDNA-based phylogenetic analysis of the producing organism

Sur Deux Algues Nouvelles Des Environs De Paris

Volume: 32Start Page: 208End Page: 21

Sur La V\ue9g\ue9tation De Quelques Sources D\u27Eau Douce Sous-Marines De La Seine-Inf\ue9rieure

Volume: 51Start Page: 36End Page: 5

Contribution A La Flore Algologique De La Haute-Auvergne

Volume: 43Start Page: 373End Page: 39

Recherches Sur Les Enveloppes Cellulaires Des Nostocac\ue9es Filamenteuses

Volume: 35Start Page: 204End Page: 23

Note Sur Un Nouveau Microscope D\u27Herborisation

Volume: 34Start Page: 216End Page: 21