Direct Speech Reconstruction From Articulatory Sensor Data by Machine Learning

This paper describes a technique that generates speech acoustics from articulator movements. Our motivation is to help people who can no longer speak following laryngectomy, a procedure that is carried out tens of thousands of times per year in the Western world. Our method for sensing articulator movement, permanent magnetic articulography, relies on small, unobtrusive magnets attached to the lips and tongue. Changes in magnetic field caused by magnet movements are sensed and form the input to a process that is trained to estimate speech acoustics. In the experiments reported here this “Direct Synthesis” technique is developed for normal speakers, with glued-on magnets, allowing us to train with parallel sensor and acoustic data. We describe three machine learning techniques for this task, based on Gaussian mixture models, deep neural networks, and recurrent neural networks (RNNs). We evaluate our techniques with objective acoustic distortion measures and subjective listening tests over spoken sentences read from novels (the CMU Arctic corpus). Our results show that the best performing technique is a bidirectional RNN (BiRNN), which employs both past and future contexts to predict the acoustics from the sensor data. BiRNNs are not suitable for synthesis in real time but fixed-lag RNNs give similar results and, because they only look a little way into the future, overcome this problem. Listening tests show that the speech produced by this method has a natural quality that preserves the identity of the speaker. Furthermore, we obtain up to 92% intelligibility on the challenging CMU Arctic material. To our knowledge, these are the best results obtained for a silent-speech system without a restricted vocabulary and with an unobtrusive device that delivers audio in close to real time. This work promises to lead to a technology that truly will give people whose larynx has been removed their voices back

Open-closed duality and Double Scaling

Nonperturbative terms in the free energy of Chern-Simons gauge theory play a key role in its duality to the closed topological string. We show that these terms are reproduced by performing a double scaling limit near the point where the perturbation expansion diverges. This leads to a derivation of closed string theory from this large-N gauge theory along the lines of noncritical string theories. We comment on the possible relevance of this observation to the derivation of superpotentials of asymptotically free gauge theories and its relation to infrared renormalons.Comment: 10 pages, LaTe

A no-go for no-go theorems prohibiting cosmic acceleration in extra dimensional models

A four-dimensional effective theory that arises as the low-energy limit of some extra-dimensional model is constrained by the higher dimensional Einstein equations. Steinhardt & Wesley use this to show that accelerated expansion in our four large dimensions can only be transient in a large class of Kaluza-Klein models that satisfy the (higher dimensional) null energy condition [1]. We point out that these no-go theorems are based on a rather ad-hoc assumption on the metric, without which no strong statements can be made.Comment: 20 page

Variational and DMRG studies of the Frustrated Antiferromagnetic Heisenberg S=1 Quantum Spin Chain

We study a frustrated antiferromagnetic isotropic Heisenberg $S=1$ chain using a variational ansatz and the DMRG. At $\alpha_D=0.284(1)$, there is a disorder point of the second kind, marking the onset of incommensurate correlations in the chain. At $\alpha_L=0.3725(25)$ there is a Lifshitz point, at which the excitation spectrum develops a doubly degenerate structure. These points are the quantum remnants of the transition from antiferromagnetic to spiral order in the classical frustrated chain. At $\alpha_T=0.7444(6)$ there is a first order phase transition from an AKLT phase to a next-nearest neighbor generalization of the AKLT model. At the transition, the string order parameter shows a discontinuous jump of 0.085 to 0; the correlation length and the gap are both finite at the transition. The problem of edge states in open frustrated chains is discussed at length.Comment: 37 pages, 14 figures, submitted to Phys.Rev.

Nonequilibrium steady state thermodynamics and fluctuations for stochastic systems

We use the work done on and the heat removed from a system to maintain it in a nonequilibrium steady state for a thermodynamic-like description of such a system as well as of its fluctuations. Based on a generalized Onsager-Machlup theory for nonequilibrium steady states we indicate two ambiguities, not present in an equilibrium state, in defining such work and heat: one due to a non-uniqueness of time-reversal procedures and another due to multiple possibilities to separate heat into work and an energy difference in nonequilibrium steady states. As a consequence, for such systems, the work and heat satisfy multiple versions of the first and second laws of thermodynamics as well as of their fluctuation theorems. Unique laws and relations appear only to be obtainable for concretely defined systems, using physical arguments to choose the relevant physical quantities. This is illustrated on a number of systems, including a Brownian particle in an electric field, a driven torsion pendulum, electric circuits and an energy transfer driven by a temperature difference.Comment: 39 pages, 3 figur

Electromagnetic vertex function of the pion at T > 0

The matrix element of the electromagnetic current between pion states is calculated in quenched lattice QCD at a temperature of $T = 0.93 T_c$. The nonperturbatively improved Sheikholeslami-Wohlert action is used together with the corresponding ${\cal O}(a)$ improved vector current. The electromagnetic vertex function is extracted for pion masses down to $360 {\rm MeV}$ and momentum transfers $Q^2 \le 2.7 {\rm GeV}^2$.Comment: 17 pages, 8 figure

Differences and homologies of chromosomal alterations within and between breast cancer cell lines: A clustering analysis

BACKGROUND: The MCF7 (ER+/HER2-), T47D (ER+/HER2-), BT474 (ER+/HER2+) and SKBR3 (ER-/HER2+) breast cancer cell lines are widely used in breast cancer research as paradigms of the luminal and HER2 phenotypes. Although they have been subjected to cytogenetic analysis, their chromosomal abnormalities have not been carefully characterized, and their differential cytogenetic profiles have not yet been established. In addition, techniques such as comparative genomic hybridization (CGH), microarray-based CGH and multiplex ligation-dependent probe amplification (MLPA) have described specific regions of gains, losses and amplifications of these cell lines; however, these techniques cannot detect balanced chromosomal rearrangements (e.g., translocations or inversions) or low frequency mosaicism. RESULTS: A range of 19 to 26 metaphases of the MCF7, T47D, BT474 and SKBR3 cell lines was studied using conventional (G-banding) and molecular cytogenetic techniques (multi-color fluorescence in situ hybridization, M-FISH). We detected previously unreported chromosomal changes and determined the content and frequency of chromosomal markers. MCF7 and T47D (ER+/HER2-) cells showed a less complex chromosomal make up, with more numerical than structural alterations, compared to BT474 and SKBR3 (HER2+) cells, which harbored the highest frequency of numerical and structural aberrations. Karyotype heterogeneity and clonality were determined by comparing all metaphases within and between the four cell lines by hierarchical clustering. The latter analysis identified five main clusters. One of these clusters was characterized by numerical chromosomal abnormalities common to all cell lines, and the other four clusters encompassed cell-specific chromosomal abnormalities. T47D and BT474 cells shared the most chromosomal abnormalities, some of which were shared with SKBR3 cells. MCF7 cells showed a chromosomal pattern that was markedly different from those of the other cell lines. CONCLUSIONS: Our study provides a comprehensive and specific characterization of complex chromosomal aberrations of MCF7, T47D, BT474 and SKBR3 cell lines. The chromosomal pattern of ER+/HER2- cells is less complex than that of ER+/HER2+ and ER-/HER2+ cells. These chromosomal abnormalities could influence the biologic and pharmacologic response of cells. Finally, although gene expression profiling and aCGH studies have classified these four cell lines as luminal, our results suggest that they are heterogeneous at the cytogenetic level

Analysis of a quenched lattice-QCD dressed-quark propagator

Quenched lattice-QCD data on the dressed-quark Schwinger function can be correlated with dressed-gluon data via a rainbow gap equation so long as that equation's kernel possesses enhancement at infrared momenta above that exhibited by the gluon alone. The required enhancement can be ascribed to a dressing of the quark-gluon vertex. The solutions of the rainbow gap equation exhibit dynamical chiral symmetry breaking and are consistent with confinement. The gap equation and related, symmetry-preserving ladder Bethe-Salpeter equation yield estimates for chiral and physical pion observables that suggest these quantities are materially underestimated in the quenched theory: |<bar-q q>| by a factor of two and f_pi by 30%.Comment: 9 pages, LaTeX2e, REVTEX4, 6 figure

On the Initial Conditions for Brane Inflation

String theory gives rise to various mechanisms to generate primordial inflation, of which ``brane inflation'' is one of the most widely considered. In this scenario, inflation takes place while two branes are approaching each other, and the modulus field representing the separation between the branes plays the role of the inflaton field. We study the phase space of initial conditions which can lead to a sufficiently long period of cosmological inflation, and find that taking into account the possibility of nonvanishing initial momentum can significantly change the degree of fine tuning of the required initial conditions.Comment: 11 pages, 2 figure

Heat release by controlled continuous-time Markov jump processes

We derive the equations governing the protocols minimizing the heat released by a continuous-time Markov jump process on a one-dimensional countable state space during a transition between assigned initial and final probability distributions in a finite time horizon. In particular, we identify the hypotheses on the transition rates under which the optimal control strategy and the probability distribution of the Markov jump problem obey a system of differential equations of Hamilton-Bellman-Jacobi-type. As the state-space mesh tends to zero, these equations converge to those satisfied by the diffusion process minimizing the heat released in the Langevin formulation of the same problem. We also show that in full analogy with the continuum case, heat minimization is equivalent to entropy production minimization. Thus, our results may be interpreted as a refined version of the second law of thermodynamics.Comment: final version, section 2.1 revised, 26 pages, 3 figure