Avatar led interventions in the Metaverse reveal that interpersonal effectiveness can be measured, predicted, and improved

Experiential learning has been known to be an engaging and effective modality for personal and professional development. The Metaverse provides ample opportunities for the creation of environments in which such experiential learning can occur. In this work, we introduce a novel interpersonal effectiveness improvement framework (ELAINE) that combines Artificial Intelligence and Virtual Reality to create a highly immersive and efficient learning experience using avatars. We present findings from a study that uses this framework to measure and improve the interpersonal effectiveness of individuals interacting with an avatar. Results reveal that individuals with deficits in their interpersonal effectiveness show a significant improvement (p < 0.02) after multiple interactions with an avatar. The results also reveal that individuals interact naturally with avatars within this framework, and exhibit similar behavioral traits as they would in the real world. We use this as a basis to analyze the underlying audio and video data streams of individuals during these interactions. We extract relevant features from these data and present a machine-learning based approach to predict interpersonal effectiveness during human-avatar conversation. We conclude by discussing the implications of these findings to build beneficial applications for the real world

INFLUENCE OF QUARTERNARY AMMONIUM SALT-OLIGOMER-25 COLIDINE (QAS-0-25C) ON SYNTHESIS OF NUCLEIC ACID IN REGENERATING TISSUES

The investigations of influencing QAS-0-25K on the reparative liver regeneration process after damage by a chemical or surgical way have been performed firstly. The dependence of the skin wound adhesion rate upon the concentration of QAS-0-25K in the films and sponges has been studied. As a result of experimental investigations the optimum doses of QAS-0-25K have been developed for the recovery of the liver after damage and also for the adhesion of the full-layer skin wounds among rats. The methods of making sponges and films have been protected an author's certificate. The obtained results have permitted to recommend QAS-0-25K as a stimulator of proliferative processes in the damaged tissuesAvailable from VNTIC / VNTIC - Scientific & Technical Information Centre of RussiaSIGLERURussian Federatio

Metaversal Learning Environments: Measuring, predicting and improving interpersonal effectiveness

Experiential learning has been known to be an engaging and effective modality for personal and professional development. The Metaverse provides ample opportunities for the creation of environments in which such experiential learning can occur. In this work, we introduce a novel architecture that combines Artificial intelligence and Virtual Reality to create a highly immersive and efficient learning experience using avatars. The framework allows us to measure the interpersonal effectiveness of an individual interacting with the avatar. We first present a small pilot study and its results which were used to enhance the framework. We then present a larger study using the enhanced framework to measure, assess, and predict the interpersonal effectiveness of individuals interacting with an avatar. Results reveal that individuals with deficits in their interpersonal effectiveness show a significant improvement in performance after multiple interactions with an avatar. The results also reveal that individuals interact naturally with avatars within this framework, and exhibit similar behavioral traits as they would in the real world. We use this as a basis to analyze the underlying audio and video data streams of individuals during these interactions. Finally, we extract relevant features from these data and present a machine-learning based approach to predict interpersonal effectiveness during human-avatar conversation. We conclude by discussing the implications of these findings to build beneficial applications for the real world.Comment: 31 Pages, 8 Figures, 3 Table

Design and Immunogenicity of SARS-CoV-2 DNA Vaccine Encoding RBD-PVXCP Fusion Protein

The potential of immune-evasive mutation accumulation in the SARS-CoV-2 virus has led to its rapid spread, causing over 600 million confirmed cases and more than 6.5 million confirmed deaths. The huge demand for the rapid development and deployment of low-cost and effective vaccines against emerging variants has renewed interest in DNA vaccine technology. Here, we report the rapid generation and immunological evaluation of novel DNA vaccine candidates against the Wuhan-Hu-1 and Omicron variants based on the RBD protein fused with the Potato virus X coat protein (PVXCP). The delivery of DNA vaccines using electroporation in a two-dose regimen induced high-antibody titers and profound cellular responses in mice. The antibody titers induced against the Omicron variant of the vaccine were sufficient for effective protection against both Omicron and Wuhan-Hu-1 virus infections. The PVXCP protein in the vaccine construct shifted the immune response to the favorable Th1-like type and provided the oligomerization of RBD-PVXCP protein. Naked DNA delivery by needle-free injection allowed us to achieve antibody titers comparable with mRNA-LNP delivery in rabbits. These data identify the RBD-PVXCP DNA vaccine platform as a promising solution for robust and effective SARS-CoV-2 protection, supporting further translational study