766 research outputs found
Quantum mechanical virial theorem in systems with translational and rotational symmetry
Generalized virial theorem for quantum mechanical nonrelativistic and
relativistic systems with translational and rotational symmetry is derived in
the form of the commutator between the generator of dilations G and the
Hamiltonian H. If the conditions of translational and rotational symmetry
together with the additional conditions of the theorem are satisfied, the
matrix elements of the commutator [G, H] are equal to zero on the subspace of
the Hilbert space. Normalized simultaneous eigenvectors of the particular set
of commuting operators which contains H, J^{2}, J_{z} and additional operators
form an orthonormal basis in this subspace. It is expected that the theorem is
relevant for a large number of quantum mechanical N-particle systems with
translational and rotational symmetry.Comment: 24 pages, accepted for publication in International Journal of
Theoretical Physic
The Dipole Coupling of Atoms and Light in Gravitational Fields
The dipole coupling term between a system of N particles with total charge
zero and the electromagnetic field is derived in the presence of a weak
gravitational field. It is shown that the form of the coupling remains the same
as in flat space-time if it is written with respect to the proper time of the
observer and to the measurable field components. Some remarks concerning the
connection between the minimal and the dipole coupling are given.Comment: 10 pages, LaTe
Fluid-membrane tethers: minimal surfaces and elastic boundary layers
Thin cylindrical tethers are common lipid bilayer membrane structures,
arising in situations ranging from micromanipulation experiments on artificial
vesicles to the dynamic structure of the Golgi apparatus. We study the shape
and formation of a tether in terms of the classical soap-film problem, which is
applied to the case of a membrane disk under tension subject to a point force.
A tether forms from the elastic boundary layer near the point of application of
the force, for sufficiently large displacement. Analytic results for various
aspects of the membrane shape are given.Comment: 12 page
Diffusive limits on the Penrose tiling
In this paper random walks on the Penrose lattice are investigated. Heat
kernel estimates and the invariance principle are shown
Input-output theory for fermions in an atom cavity
We generalize the quantum optical input-output theory developed for optical
cavities to ultracold fermionic atoms confined in a trapping potential, which
forms an "atom cavity". In order to account for the Pauli exclusion principle,
quantum Langevin equations for all cavity modes are derived. The dissipative
part of these multi-mode Langevin equations includes a coupling between cavity
modes. We also derive a set of boundary conditions for the Fermi field that
relate the output fields to the input fields and the field radiated by the
cavity. Starting from a constant uniform current of fermions incident on one
side of the cavity, we use the boundary conditions to calculate the occupation
numbers and current density for the fermions that are reflected and transmitted
by the cavity
Squeezed States in the de Sitter Vacuum
We discuss the treatment of squeezed states as excitations in the Euclidean
vacuum of de Sitter space. A comparison with the treatment of these states as
candidate no-particle states, or alpha-vacua, shows important differences
already in the free theory. At the interacting level alpha-vacua are
inconsistent, but squeezed state excitations seem perfectly acceptable. Indeed,
matrix elements can be renormalized in the excited states using precisely the
standard local counterterms of the Euclidean vacuum. Implications for
inflationary scenarios in cosmology are discussed.Comment: 15 pages, no figures. One new citation in version 3; no other change
Clinical and molecular characterization of HER2 amplified-pancreatic cancer
<p>Background:
Pancreatic cancer is one of the most lethal and molecularly diverse malignancies. Repurposing of therapeutics that target specific molecular mechanisms in different disease types offers potential for rapid improvements in outcome. Although HER2 amplification occurs in pancreatic cancer, it is inadequately characterized to exploit the potential of anti-HER2 therapies.</p>
<p>Methods:
HER2 amplification was detected and further analyzed using multiple genomic sequencing approaches. Standardized reference laboratory assays defined HER2 amplification in a large cohort of patients (n = 469) with pancreatic ductal adenocarcinoma (PDAC).</p>
<p>Results:
An amplified inversion event (1 MB) was identified at the HER2 locus in a patient with PDAC. Using standardized laboratory assays, we established diagnostic criteria for HER2 amplification in PDAC, and observed a prevalence of 2%. Clinically, HER2- amplified PDAC was characterized by a lack of liver metastases, and a preponderance of lung and brain metastases. Excluding breast and gastric cancer, the incidence of HER2-amplified cancers in the USA is >22,000 per annum.</p>
<p>Conclusions:
HER2 amplification occurs in 2% of PDAC, and has distinct features with implications for clinical practice. The molecular heterogeneity of PDAC implies that even an incidence of 2% represents an attractive target for anti-HER2 therapies, as options for PDAC are limited. Recruiting patients based on HER2 amplification, rather than organ of origin, could make trials of anti-HER2 therapies feasible in less common cancer types.</p>
Quantum measurement in a family of hidden-variable theories
The measurement process for hidden-configuration formulations of quantum
mechanics is analysed. It is shown how a satisfactory description of quantum
measurement can be given in this framework. The unified treatment of
hidden-configuration theories, including Bohmian mechanics and Nelson's
stochastic mechanics, helps in understanding the true reasons why the problem
of quantum measurement can succesfully be solved within such theories.Comment: 16 pages, LaTeX; all special macros are included in the file; a
figure is there, but it is processed by LaTe
Blackbody Radiation and the Scaling Symmetry of Relativistic Classical Electron Theory with Classical Electromagnetic Zero-Point Radiation
It is pointed out that relativistic classical electron theory with classical
electromagnetic zero-point radiation has a scaling symmetry which is suitable
for understanding the equilibrium behavior of classical thermal radiation at a
spectrum other than the Rayleigh-Jeans spectrum. In relativistic classical
electron theory, the masses of the particles are the only scale-giving
parameters associated with mechanics while the action-angle variables are scale
invariant. The theory thus separates the interaction of the action variables of
matter and radiation from the scale-giving parameters. Classical zero-point
radiation is invariant under scattering by the charged particles of
relativistic classical electron theory. The basic ideas of the matter
-radiation interaction are illustrated in a simple relativistic classical
electromagnetic example.Comment: 18 page
Barrier effects on the collective excitations of split Bose-Einstein condensates
We investigate the collective excitations of a single-species Bose gas at T=0
in a harmonic trap where the confinement undergoes some splitting along one
spatial direction. We mostly consider onedimensional potentials consisting of
two harmonic wells separated a distance 2 z_0, since they essentially contain
all the barrier effects that one may visualize in the 3D situation. We find,
within a hydrodynamic approximation, that regardless the dimensionality of the
system, pairs of levels in the excitation spectrum, corresponding to
neighbouring even and odd excitations, merge together as one increases the
barrier height up to the current value of the chemical potential. The
excitation spectra computed in the hydrodynamical or Thomas-Fermi limit are
compared with the results of exactly solving the time-dependent
Gross-Pitaevskii equation. We analyze as well the characteristics of the
spatial pattern of excitations of threedimensional boson systems according to
the amount of splitting of the condensate.Comment: RevTeX, 12 pages, 13 ps figure
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