Subversion and the State: Politics of Moroccan Hip-Hop and Rap Music

This paper examines the political significance of recent developments within the Moroccan hiphop scene in the period following the “Arab Spring.” Since its emergence in the 1980s, Moroccan hip-hop has been used as a medium through which artists have been able to comment on social and political issues. During the past two decades with Morocco under the rule of King Mohammed VI, the content and implications of this art have undergone a transformation, particularly with regard to political commentary and artists’ relationship to the state. This research explores the evolution of hip-hop and rap music in Morocco over that time period, especially analyzing its political implications in the age following the February 20th movement. This study reveals an increasing trend of movement away from explicitly political music, as determined through integration of existing scholarship and semi-structured interviews conducted with seven individuals intimately involved in the hip-hop and musical scenes in Rabat and Casablanca. I argue that this tendency is representative not of decreasing artistic political involvement but rather of a reincarnation of dissent in a unique sociopolitical climate

Unpacking Political Identity in First-Time Voting Christian Women: An Interpretative Phenomenological Analysis

As political science tends to focus on polling and statistical analysis to examine individuals’ voting behaviors, the reasoning behind constituents’ decision-making process is often left in the dark. This is particularly true in first-time voting women who come from religious backgrounds that uphold complementarian gender values. This study focuses on the following research questions: How do women experience their political identity in relation to their gender identity? How do women experience their political identity in relation to their religious or faith identity? How do women experience their political identity in relation to voting for the first time? I answer these questions using interpretive phenomenological analysis (IPA) on interviews with first-time voting Christian women (n = 4) from the south, two of whom voted for Donald Trump and two of whom voted for Joseph Biden in the 2020 presidential election. Through in-depth IPA analysis of descriptive, linguistic, and conceptual elements as well as individual and cross-case analysis, I found the following themes: establishing political identity through social identifications, maintaining both agency and communion in political identity in relation to family, and struggling between agency and communion in political identity amongst peers. My findings provide a framework for the psychological experiences and commonality that provide contextual depth of framing how first-time voting Christian women examine and experience their identities amid political participation

Teaching the discrimination between fact and opinion in grades four and five

Thesis (Ed.M.)--Boston Universit

Investigation of the biomechanics of running and rapid change-of-direction tasks

Rapid change-of-direction tasks have been associated with non-contact anterior cruciate ligament (ACL) injuries and females are more likely to suffer this injury compared to males. The purpose of this investigation was to evaluate the biomechanical behavior of running and three rapid change-of-direction tasks and determine whether sex differences exist across tasks. The biomechanical factors included knee and hip kinematics and kinetics, in addition to static lower extremity alignment and dynamic hip strength. Data were collected in a controlled laboratory setting on healthy collegiate female and male basketball and soccer players (N = 21). Three-dimensional kinematics and kinetics were recorded in conditions of running, lateral false step, sidestep cut, and a combination of a lateral false step with a sidestep cut. Static lower extremity alignment was represented by measurement of standing Q-angle. Hip strength was determined by measuring isokinetic eccentric hip abduction strength. Three queries were addressed: 1.) sex differences in the kinetics and kinematics of the knee and hip during running and rapid change-of-direction tasks, 2.) the effect of sex on relationships of standing Q-angle and hip strength to frontal plane knee biomechanics, and 3.) description of the patterning of knee and hip biomechanics across tasks and sex. The results of this study suggest knee abduction and internal moments of knee adduction and hip abduction increase when athletes step laterally in combination with a sidestep cut compared to all other tasks. Females demonstrate differences in hip position and loading compared to males across the four tasks. The data did not support evidence of an effect of sex on standing Q-angle or hip abduction strength. Additionally, no relationships between sex, standing Q-angle, or hip abduction strength to frontal plane knee biomechanics were found. Four patterns of knee and hip kinematics and kinetics were found to describe lower extremity biomechancis during running and rapid change-of direction tasks. In summary, the addition of frontal plane motion and loading during change-of-direction tasks significantly affected knee position in a manner associated with ACL injury. Differences in lower extremity kinematics and kinetics between females and males appear to be specific to hip position and loading

Virtual Play Creation

Students work in groups to write, direct and perform a piece of virtual theatre with the goal to create a set of "best practices" for virtual theatre as a partnership with the Pheonix Theatre. Students are divided into three groups to pitch three unique Zoom play proposals and develop one selected proposal into a 1-3 minute, 3-6 minute, and finally an 8-20 minute play. Each group will present their full play at the end of the semester in a virtual play showcase put on by the class. Throughout the semester, students complete both self-assessments and peer assessments to measure professionalism, problem-solving, collaboration, adaptability, and resilience

Evaluating the Clinical Feasibility of an Artificial Intelligence-Powered, Web-Based Clinical Decision Support System for the Treatment of Depression in Adults: Longitudinal Feasibility Study.

BACKGROUND: Approximately two-thirds of patients with major depressive disorder do not achieve remission during their first treatment. There has been increasing interest in the use of digital, artificial intelligence-powered clinical decision support systems (CDSSs) to assist physicians in their treatment selection and management, improving the personalization and use of best practices such as measurement-based care. Previous literature shows that for digital mental health tools to be successful, the tool must be easy for patients and physicians to use and feasible within existing clinical workflows. OBJECTIVE: This study aims to examine the feasibility of an artificial intelligence-powered CDSS, which combines the operationalized 2016 Canadian Network for Mood and Anxiety Treatments guidelines with a neural network-based individualized treatment remission prediction. METHODS: Owing to the COVID-19 pandemic, the study was adapted to be completed entirely remotely. A total of 7 physicians recruited outpatients diagnosed with major depressive disorder according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition criteria. Patients completed a minimum of one visit without the CDSS (baseline) and 2 subsequent visits where the CDSS was used by the physician (visits 1 and 2). The primary outcome of interest was change in appointment length after the introduction of the CDSS as a proxy for feasibility. Feasibility and acceptability data were collected through self-report questionnaires and semistructured interviews. RESULTS: Data were collected between January and November 2020. A total of 17 patients were enrolled in the study; of the 17 patients, 14 (82%) completed the study. There was no significant difference in appointment length between visits (introduction of the tool did not increase appointment length; F2,24=0.805; mean squared error 58.08; P=.46). In total, 92% (12/13) of patients and 71% (5/7) of physicians felt that the tool was easy to use; 62% (8/13) of patients and 71% (5/7) of physicians rated that they trusted the CDSS. Of the 13 patients, 6 (46%) felt that the patient-clinician relationship significantly or somewhat improved, whereas 7 (54%) felt that it did not change. CONCLUSIONS: Our findings confirm that the integration of the tool does not significantly increase appointment length and suggest that the CDSS is easy to use and may have positive effects on the patient-physician relationship for some patients. The CDSS is feasible and ready for effectiveness studies. TRIAL REGISTRATION: ClinicalTrials.gov NCT04061642; http://clinicaltrials.gov/ct2/show/NCT04061642

Seeing Is Believing: Illuminating the Source of In Vivo Interleukin-7

Interleukin-7 (IL-7) is an essential cytokine for T cells. However, IL-7 is not produced by T cells themselves such that T cells are dependent on extrinsic IL-7. In fact, in the absence of IL-7, T cell development in the thymus as well as survival of naive T cells in the periphery is severely impaired. Furthermore, modulating IL-7 availability in vivo either by genetic means or other experimental approaches determines the size, composition and function of the T cell pool. Consequently, understanding IL-7 expression is critical for understanding T cell immunity. Until most recently, however, the spatiotemporal expression of in vivo IL-7 has remained obscured. Shortage of such information was partly due to scarce expression of IL-7 itself but mainly due to the lack of adequate reagents to monitor IL-7 expression in vivo. This situation dramatically changed with a recent rush of four independent studies that describe the generation and characterization of IL-7 reporter mice, all utilizing bacterial artificial chromosome transgene technology. The emerging consensus of these studies confirmed thymic stromal cells as the major producers of IL-7 but also identified IL-7 reporter activities in various peripheral tissues including skin, intestine and lymph nodes. Strikingly, developmental and environmental cues actively modulated IL-7 reporter activities in vivo suggesting that IL-7 regulation might be a new mechanism of shaping T cell development and homeostasis. Collectively, the availability of these new tools opens up new venues to assess unanswered questions in IL-7 biology in T cells and beyond

Search for Limiting Factors in the RNAi Pathway in Silkmoth Tissues and the Bm5 Cell Line: The RNA-Binding Proteins R2D2 and Translin

RNA interference (RNAi), an RNA-dependent gene silencing process that is initiated by double-stranded RNA (dsRNA) molecules, has been applied with variable success in lepidopteran insects, in contrast to the high efficiency achieved in the coleopteran Tribolium castaneum. To gain insight into the factors that determine the efficiency of RNAi, a survey was carried out to check the expression of factors that constitute the machinery of the small interfering RNA (siRNA) and microRNA (miRNA) pathways in different tissues and stages of the silkmoth, Bombyx mori. It was found that the dsRNA-binding protein R2D2, an essential component in the siRNA pathway in Drosophila, was expressed at minimal levels in silkmoth tissues. The silkmoth-derived Bm5 cell line was also deficient in expression of mRNA encoding full-length BmTranslin, an RNA-binding factor that has been shown to stimulate the efficiency of RNAi. However, despite the lack of expression of the RNA-binding proteins, silencing of a luciferase reporter gene was observed by co-transfection of luc dsRNA using a lipophilic reagent. In contrast, gene silencing was not detected when the cells were soaked in culture medium supplemented with dsRNA. The introduction of an expression construct for Tribolium R2D2 (TcR2D2) did not influence the potency of luc dsRNA to silence the luciferase reporter. Immunostaining experiments further showed that both TcR2D2 and BmTranslin accumulated at defined locations within the cytoplasm of transfected cells. Our results offer a first evaluation of the expression of the RNAi machinery in silkmoth tissues and Bm5 cells and provide evidence for a functional RNAi response to intracellular dsRNA in the absence of R2D2 and Translin. The failure of TcR2D2 to stimulate the intracellular RNAi pathway in Bombyx cells is discussed

Characteristics of HIV-1 Discordant Couples Enrolled in a Trial of HSV-2 Suppression to Reduce HIV-1 Transmission: The Partners Study

Background: The Partners HSV-2/HIV-1 Transmission Study (Partners Study) is a phase III, placebo-controlled trial of daily acyclovir for genital herpes (HSV-2) suppression among HIV-1/HSV-2 co-infected persons to reduce HIV-1 transmission to their HIV-1 susceptible partners, which requires recruitment of HIV-1 serodiscordant heterosexual couples. We describe the baseline characteristics of this cohort. Methods: HIV-1 serodiscordant heterosexual couples, in which the HIV-1 infected partner was HSV-2 seropositive, had a CD4 count ≥250 cells/mcL and was not on antiretroviral therapy, were enrolled at 14 sites in East and Southern Africa. Demographic, behavioral, clinical and laboratory characteristics were assessed. Results: Of the 3408 HIV-1 serodiscordant couples enrolled, 67% of the HIV-1 infected partners were women. Couples had cohabitated for a median of 5 years (range 2–9) with 28% reporting unprotected sex in the month prior to enrollment. Among HIV-1 susceptible participants, 86% of women and 59% of men were HSV-2 seropositive. Other laboratory-diagnosed sexually transmitted infections were uncommon (500 relative to <350, respectively, p<0.001). Conclusions: The Partners Study successfully enrolled a cohort of 3408 heterosexual HIV-1 serodiscordant couples in Africa at high risk for HIV-1 transmission. Follow-up of this cohort will evaluate the efficacy of acyclovir for HSV-2 suppression in preventing HIV-1 transmission and provide insights into biological and behavioral factors determining heterosexual HIV-1 transmission. Trial Registration ClinicalTrials.gov NCT0019451