Mass loss

Observational evidence for mass loss from cool stars is reviewed. Spectra line profiles are used for the derivation of mass-loss rates with the aid of the equation of continuity. This equation implies steady mass loss with spherical symmetry. Data from binary stars, Mira variables, and red giants in globular clusters are examined. Silicate emission is discussed as a useful indicator of mass loss in the middle infrared spectra. The use of thermal millimeter-wave radiation, Very Large Array (VLA) measurement of radio emission, and OH/IR masers are discussed as a tool for mass loss measurement. Evidence for nonsteady mass loss is also reviewed

The abundance of atmospheric carbon dioxide and its isotopes

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/32521/1/0000614.pd

The M-type stars

The papers in this volume cover the following topics: (1) basic properties and photometric variability of M and related stars; (2) spectroscopy and nonthermal processes; (3) circumstellar radio molecular lines; (4) circumstellar shells, the formation of grains, and radiation transfer; (5) mass loss; (6) circumstellar chemistry; (7) thermal atmospheric models; (8) quasi-thermal models; (9) observations on the atmospheres of M dwarfs; and (1) theoretical work on M dwarfs

Canopy flow and aspects of the response of plants protected by herbaceous shelterbelts and wood fences

Field experiments have been conducted in the semiarid southwest region of La Pampa, Argentina, in order to investigate the effect of different types of windbreak on wind characteristics and growth parameters of wheat (Triticum aestivum, Buck Charrua variety) within the sheltered region. Windbreaks decrease wind speed, reducing damage to the crop and improving yield and quality. Sheltering may improve microclimate conditions for plant growth and protects the soil from wind erosion. Aspects of the sheltering ability of four different windbreaks have been tested: single and double row herbaceous (Tritio secale) shelterbelts, and two different artificial wooden fences, with the same overall average porosity, but with different porosity distributions. Mean velocity, turbulence intensity, skewness distributions and spectral and wavelet analysis have been performed in order to characterise the turbulent flow downstream of the different windbreaks. Wheat grain yield and harvest index were compared with adjacent unsheltered plantations. The single and double row shelterbelts enhanced the grain yield and the harvest index of the protected plants. An influence of the turbulent structure on plant growth is suggested by the different response of plants sheltered by the two types of artificial fences.Facultad de Ingenierí

Do antidepressants cure or create abnormal brain states?

Moncrieff and Cohen argue that psychotropic drugs create abnormal states that may co-incidentally relieve symptoms of mental illness

Canopy flow and aspects of the response of plants protected by herbaceous shelterbelts and wood fences

Field experiments have been conducted in the semiarid southwest region of La Pampa, Argentina, in order to investigate the effect of different types of windbreak on wind characteristics and growth parameters of wheat (Triticum aestivum, Buck Charrua variety) within the sheltered region. Windbreaks decrease wind speed, reducing damage to the crop and improving yield and quality. Sheltering may improve microclimate conditions for plant growth and protects the soil from wind erosion. Aspects of the sheltering ability of four different windbreaks have been tested: single and double row herbaceous (Tritio secale) shelterbelts, and two different artificial wooden fences, with the same overall average porosity, but with different porosity distributions. Mean velocity, turbulence intensity, skewness distributions and spectral and wavelet analysis have been performed in order to characterise the turbulent flow downstream of the different windbreaks. Wheat grain yield and harvest index were compared with adjacent unsheltered plantations. The single and double row shelterbelts enhanced the grain yield and the harvest index of the protected plants. An influence of the turbulent structure on plant growth is suggested by the different response of plants sheltered by the two types of artificial fences.Facultad de Ingenierí

How spiking neurons give rise to a temporal-feature map

A temporal-feature map is a topographic neuronal representation of temporal attributes of phenomena or objects that occur in the outside world. We explain the evolution of such maps by means of a spike-based Hebbian learning rule in conjunction with a presynaptically unspecific contribution in that, if a synapse changes, then all other synapses connected to the same axon change by a small fraction as well. The learning equation is solved for the case of an array of Poisson neurons. We discuss the evolution of a temporal-feature map and the synchronization of the single cells’ synaptic structures, in dependence upon the strength of presynaptic unspecific learning. We also give an upper bound for the magnitude of the presynaptic interaction by estimating its impact on the noise level of synaptic growth. Finally, we compare the results with those obtained from a learning equation for nonlinear neurons and show that synaptic structure formation may profit from the nonlinearity

Rare variants in optic disc area gene CARD10 enriched in primary open-angle glaucoma

Background: Genome-wide association studies (GWAS) have identified association of common alleles with primary open-angle glaucoma (POAG) and its quantitative endophenotypes near numerous genes. This study aims to determine whether rare pathogenic variants in these disease-associated genes contribute to POAG. Methods: Participants fulfilled strict inclusion criteria of advanced POAG at a young age of diagnosis. Myocilin mutation carriers were excluded using direct sequencing. Whole exome sequencing was performed on 187 glaucoma cases and 103 local screened nonglaucoma controls then joint-called with exomes of 993 previously sequenced Australian controls. GWAS-associated genes were assessed for enrichment of rare predicted pathogenic variants in POAG. Significantly enriched genes were compared against Exome Aggregation Consortium (ExAC) public control. Results: Eighty-six GWAS disease or trait-associated glaucoma genes were captured and sequenced. CARD10 showed enrichment after Bonferroni correction for rare variants in glaucoma cases (OR = 13.2, P = 6.94 × 10−5) with mutations identified in 4.28% of our POAG cohort compared to 0.27% in controls. CARD10 was significantly associated with optic disc parameters in previous GWAS. The whole GWAS gene set showed no enrichment in POAG overall (OR = 1.12, P = 0.51). Conclusion: We report here an enrichment of rare predicted pathogenic coding variants within a GWAS-associated locus in POAG (CARD10). These findings indicate that both common and rare pathogenic coding variants in CARD10 may contribute to POAG pathogenesis.Tiger Zhou, Emmanuelle Souzeau, Shiwani Sharma, Owen M. Siggs, Ivan Goldberg, Paul R. Healey, Stuart Graham, Alex W. Hewitt, David A. Mackey, Robert J. Casson, John Landers, Richard Mills, Jonathan Ellis, Paul Leo, Matthew A. Brown, Stuart MacGregor, Kathryn P. Burdon and Jamie E. Crai

Binets: fundamental building blocks for phylogenetic networks

Phylogenetic networks are a generalization of evolutionary trees that are used by biologists to represent the evolution of organisms which have undergone reticulate evolution. Essentially, a phylogenetic network is a directed acyclic graph having a unique root in which the leaves are labelled by a given set of species. Recently, some approaches have been developed to construct phylogenetic networks from collections of networks on 2- and 3-leaved networks, which are known as binets and trinets, respectively. Here we study in more depth properties of collections of binets, one of the simplest possible types of networks into which a phylogenetic network can be decomposed. More speci_cally, we show that if a collection of level-1 binets is compatible with some binary network, then it is also compatible with a binary level-1 network. Our proofs are based on useful structural results concerning lowest stable ancestors in networks. In addition, we show that, although the binets do not determine the topology of the network, they do determine the number of reticulations in the network, which is one of its most important parameters. We also consider algorithmic questions concerning binets. We show that deciding whether an arbitrary set of binets is compatible with some network is at least as hard as the well-known Graph Isomorphism problem. However, if we restrict to level-1 binets, it is possible to decide in polynomial time whether there exists a binary network that displays all the binets. We also show that to _nd a network that displays a maximum number of the binets is NP-hard, but that there exists a simple polynomial-time 1/3-approximation algorithm for this problem. It is hoped that these results will eventually assist in the development of new methods for constructing phylogenetic networks from collections of smaller networks

Bringing Open Data to Whole Slide Imaging

Supplementary information associated with Besson et al. (2019) ECDP 2019 Faced with the need to support a growing number of whole slide imaging (WSI) file formats, our team has extended a long-standing community file format (OME-TIFF) for use in digital pathology. The format makes use of the core TIFF specification to store multi-resolution (or "pyramidal") representations of a single slide in a flexible, performant manner. Here we describe the structure of this format, its performance characteristics, as well as an open-source library support for reading and writing pyramidal OME-TIFFs