Új pd-komplexek azometin-származékokkal, és fizikai-kémiai vizsgálatuk

In our research we synthesized novel [Pd(monophenyl-dioxime)2L2] (L = 2-aminopyrimidine, 3-hydroxi-aniline, lepidine) type complexes and with different Schiff-bases: [Pd(acetonyl-acetone)2(diamine)], [Pd(dibenzoyl-methane)2(diamine)] (diamine = ophenylene-diamine, ethylene-diamine, 1,2-, 1,3-propylene-diamine) by reacting PdCl2, monophenyl-dioxime, respectively Schiff-bases with amine, respectively diamine in the corresponding solvent. We analyzed their physicochemical properties using mass spectrometry, infrared-, NMR-spectroscopy and thermal analysis (TG, DTG and DTA). The Pd-complexes have an important role in many organic chemistry reactions as catalysts [1]. Some of them are used in industry. The Pd precious metal price is high, but compared with Rh, Pt, Ir, or Os is infinitesimal. Regarding the biological activity, they inhibit some enzymes which are important in anti-diabetic therapy. Some of the Pd(II) complexes are anti-glaucoma drug candidates [2]. Due to the similarity between Pd and Pt, the complexes of palladium(II) can be considered as potential anticancer agents [3]

Új Cu-komplexek Schiff-bázisokkal és fizikai-kémiai vizsgálatuk

In our research we synthesized novel [Cu(4-benzyl-2-hydroxy-propiophenone)2A], [Cu(ninhydrin)2A] (A = ethylene-diamine, 1,2-, 1,3-propylene-diamine, o-phenylene-diamine) type complexes by reacting copper-acetate with different Schiff-bases in the corresponding solvent. The Schiff-bases were obtained with the condensation of 4-benzyl-2-hydroxypropiophenone,respectively ninhydrin with diamines. We analyzed their physicochemical properties using mass spectrometry, infrared-, NMR-, UV–VIS-, ESR-spectroscopy, powderXRD and thermal analysis (TG, DTG and DTA). The copper(II)-complexes are used as antimicrobial agents. The copper(II)-complexes with aminoacids-, peptides-, chinoxaline-, mono- and bis-semicarbazones ligands are used in cancer therapy. The copper is an essential microelement in the human body. It has a very important role in the convalescence processes. The objective of the authors is to study the biological activity of the prepared complexes

Novel nickel complexes with schiff bases and α-glyoximes, synthesis and physical-chemical study

Nickel complexes, especially with Schiff bases gain potential interest in various areas such as catalysis, luminescent probes in analytical chemistry, dye and polymer industry, food industry, magneto-structural chemistry, agrochemistry, biological fields and several miscellaneous applications. There are numerous reports on the biological activities of Schiff base ligands and their metal complexes, including their use for DNA cleavage, enzyme modeling, and as antimicrobial, antifungal and antitumor agents [1]. In our research, new nickel complexes were synthesized with α-glyoximes, such as [Ni(Me-propyl-GlyoxH)2(imidazole)2], [Ni(Me-pentyl-GlyoxH)2(diisopropyl-amine)2], [Ni((4-benzyl-2-hydroxy-phenyl)-Me-GlyoxH)2], where GlyoxH = mono deprotonated glyoxime, and with Schiff bases, such as [Ni(3-heptanone)2A], [Ni(propiophenone)2A], A = ethylenediamine (en), 1,2-, 1,3-propylenediamine (1,2-pn, 1,3-pn), o-phenylene-diamine (o-fen). The Schiff bases were obtained with a simple condensation reaction between 3- heptanone or propiophenone and the corresponding diamines. The molecular structure of our products was investigated by IR, UV–VIS spectroscopy, mass spectrometry (MS), thermoanalytical measurements (TG-DTG-DTA), and powder XRD. The biological activity was studied for a few bacteria, however, these complexes have shown no antibacterial activity so far

Új Fe(II)-komplexek előállítása α-dioximokkal, bórsavval sé észtereivel, szemi- és tioszemikarbazonokkal, schiffbázisokkal, valamint fizikai-kémiai és biológiai vizsgálatuk

In our research project new iron(II) complexes were synthesized with azomethines, such as [Fe(1,4-dibromo-2,3-butane-GlyoxH)2(3-HO-aniline)2], [Fe(1,4-dibromo-2,3-butaneGlyoxH)2(2-amino-pyrimidine)2], [Fe(4-benzyl-2-HO-propiophenone-GlyoxH)2], [Fe(5- methyl-2-hexanone)2(en)], [Fe(5-methyl-2-hexanone)2(1,2-pn)], [Fe(5-methyl-2-hexanone)2 (1,3-pn)], [Fe(5-methyl-2-hexanone)2(o-fen)], [Fe(2,4,5-trimethoxy-acetophenone-SC)2], [Fe(2,4,5-trimethoxy-acetophenone-TSC)2], [Fe(5-methyl-2-hexanone-SC)2], [Fe(5-methyl-2- hexanone-TSC)2], [Fe(Me-Pr-Glyox)3(BOH)2], [Fe(Me-Pr-Glyox)3(BOMe)2], [Fe(Me-i-BuGlyox)3(BOH)2], [Fe(Me-i-Bu-Glyox)3(BOMe)2], [Fe(Me-i-Bu-Glyox)3(BO-n-propyl)2] (en = ethylenedianine, pn = propylenediamine, fen = phenylenediamine, SC = semicarbazone, TSC = thiosemicarbazone), by reacting iron(II)-chloride with different glyoximes, Schiff-bases, semi- or thiosemicarbazones in suitable solvent. The Schiff-bases were obtained with the condensation of 5-methyl-2-hexanone, with diamines. The semi- or thiosemicarbazones were prepared by the condensation of 2,4,5-trimethoxy-acetophenone or 5-methyl-2-hexanone with semicarbazide or thiosemicarbazide. We analyzed their physicochemical properties using mass spectrometry, infrared-, NMR-, UV–VIS-, Mössbauer-spectroscopy, powder-XRD and thermal analysis (TG, DTG and DTA). The biological activity of complexes, especially their antibacterial activity was also explored. The importance of this class of compounds is gained in biochemistry, since some of them act as antibacterial agents and potential anticancer drugs. Furthermore, some members can play role as catalysts in organic chemistry transformations [1–2]

Synthesis of novel Pt complexes with α-glyoximes, schiff bases and their physical-chemical and biological study

Platinum-complexes permanently play an important role in the medical treatment of tumor cells. Since Pt has a soft-type Lewis acidic character, it forms the most stable complexes with S, P, N and I donor atoms, resulting planar (cisplatine) or octahedral (satraplatine) arrangement of ligands. In our research, new platinum complexes were synthesized with α-glyoximes, such as [Pt(diethyl-glyoxH)2(amine)2], where glyoxH = mono deprotonated glyoxime, amine = imidazole, 2-amino-pyrimidine or 3-hydroxy-aniline, and with Schiff bases, such as [Pt(3-heptanone)2(en)], [Pt(3-heptanone)2(1,2-pn)], [Pt(3-heptanone)2(1,3-pn)] (en = ethylenediamine, pn = propylenediamine). The Schiff bases were obtained with the condensation reaction between 3-heptanone and the corresponding diamines. The molecular structure of our products has been investigated by IR, UV–VIS and NMR spectroscopy, MS, thermoanalytical measurements (TG-DTG-DTA), and powder XRD. The biological activity study of compounds revealed their possible application in medical point of view since some of them proved to act as antibacterial agents and potential anticancer drugs. On the other hand, some members of the family of complexes can play catalytic role in organic chemistry transformations