Unsteady fluid force acting on oscillating square-section cylinder

10.1061/(ASCE)0733-9399(1995)121:1(176)Journal of Engineering Mechanics1211176-180JENM

Multilineage potential of bone-marrow-derived mesenchymal stem cell cell sheets: Implications for tissue engineering

10.1089/ten.tea.2009.0501Tissue Engineering - Part A1641421-143

Effects of radial compression on a novel simulated intervertebral disc-like assembly using bone marrow-derived mesenchymal stem cell cell-sheets for annulus fibrosus regeneration

10.1097/BRS.0b013e31821986b3Spine36211744-1751SPIN

TVM telecommunication and TV mobile

10.1109/INDIN.2006.2756542006 IEEE International Conference on Industrial Informatics, INDIN'06742-74

IRAK1 is a therapeutic target that drives breast cancer metastasis and resistance to paclitaxel

10.1038/ncomms9746Nature Communications6874

Erratum: IRAK1 is a therapeutic target that drives breast cancer metastasis and resistance to paclitaxel (Nature Communications (2015) 6 (8746) DOI: 10.1038/ncomms9746)

10.1038/ncomms10054Nature Communications61005

Logic Programming Languages for the Internet

We specify the major characteristics of the Internet under the headings: heterogeneity, service characteristics, dynamic nature, no global notions, and unreliability (i.e. security and partial failure). In the process, we identify ve categories of Internet services: hosts, active entities, agents, semistructured data, and passive code. Logic Programming (LP

Factors Affecting the Successful Realisation of Benefits from Systems Development Projects: Findings from Three Case Studies

This article was published in the Journal of Information Technology [© Palgrave Macmillan] and the definitive version is available at: http://dx/doi.org/10.1057/jit.2011.8The return that organisations derive from investments in information systems and technology continues to disappoint. While there is a very significant body of literature on the factors that should facilitate a successful outcome from systems development, there is growing concern that these prescriptions are not having their desired effect. In this paper, we argue that the success of a systems development project should be measured in terms of its ability to deliver meaningful benefits, rather than the timely delivery of a technical artefact, and therefore organisations should adopt an explicit and proactive benefits realisation approach when investing in IT. Consequently, we sought to explore those actionable factors that might facilitate the effective realisation of benefits from systems development initiatives. Three organisations were identified that claimed to adopt a proactive approach to benefits realisation, and detailed studies of their systems development practices were conducted. Our analysis found that whilst one organisation had been successful in its adoption of a benefits realisation perspective, the other two had not, and this allowed us to identify those factors that helped to explain this difference in outcomes. In short, this paper makes an important contribution by identifying how a sub-set of traditional systems success factors might be enhanced, to give them a more explicit benefits realisation orientation. Moreover, it presents a coherent set of principles that can be used for deriving other factors and practices

Critical care usage after major gastrointestinal and liver surgery: a prospective, multicentre observational study

Background Patient selection for critical care admission must balance patient safety with optimal resource allocation. This study aimed to determine the relationship between critical care admission, and postoperative mortality after abdominal surgery. Methods This prespecified secondary analysis of a multicentre, prospective, observational study included consecutive patients enrolled in the DISCOVER study from UK and Republic of Ireland undergoing major gastrointestinal and liver surgery between October and December 2014. The primary outcome was 30-day mortality. Multivariate logistic regression was used to explore associations between critical care admission (planned and unplanned) and mortality, and inter-centre variation in critical care admission after emergency laparotomy. Results Of 4529 patients included, 37.8% (n=1713) underwent planned critical care admissions from theatre. Some 3.1% (n=86/2816) admitted to ward-level care subsequently underwent unplanned critical care admission. Overall 30-day mortality was 2.9% (n=133/4519), and the risk-adjusted association between 30-day mortality and critical care admission was higher in unplanned [odds ratio (OR): 8.65, 95% confidence interval (CI): 3.51–19.97) than planned admissions (OR: 2.32, 95% CI: 1.43–3.85). Some 26.7% of patients (n=1210/4529) underwent emergency laparotomies. After adjustment, 49.3% (95% CI: 46.8–51.9%, P<0.001) were predicted to have planned critical care admissions, with 7% (n=10/145) of centres outside the 95% CI. Conclusions After risk adjustment, no 30-day survival benefit was identified for either planned or unplanned postoperative admissions to critical care within this cohort. This likely represents appropriate admission of the highest-risk patients. Planned admissions in selected, intermediate-risk patients may present a strategy to mitigate the risk of unplanned admission. Substantial inter-centre variation exists in planned critical care admissions after emergency laparotomies