1 research outputs found
Age-Related Loss of GABA-Positive and GABA-Negative Neurons in Neocortical Transplants
The numerical density of GABA
immunopositive and GABA immunonegative
neurons was quantitatively determined in 0, 12,
30 and 90 day-old neocortical transplants,
derived from E17 rat embryos and transplanted
into adult hosts. It was found that the original,
very high neuronal density in the fetal
transplant declined steadily after
transplantation to the somatosensory cortex of
adult rat. The decline in numerical density of
GABA-positive neurons, however, was
disproportionately larger than that of GABA-negative
nerve cells: At 90 days the proportion
of GABA-positive cells was 2.3% (in contrast to
the 11.8% in the adult host cortex). The density
of GABA-negative neurons, on the other hand,
remained slightly higher than comparable
values in the control cortex. The decline in
density Of GABA-positive neurons was
continuous until the 90th post-transplantation
day, while final, close to normal density values
of GABA-negative nerve cells were already
reached in 30 day-old grafts, with no significant
change afterwards