Estudo conceitual de fornos de chama direta instalados em uma planta de gás localizada em Sabana de Torres

En este estudio técnico se llevó a cabo un análisis operativo a dos hornos de calentamiento de llama directa donde se identificaron posibles factores que impactan su eficiencia y, con base en la literatura asociada a esta tecnología, se plantearon alternativas que podrían mejorar su desempeño disminuyendo el consumo de gas combustible. Se realizó una compilación y depuración de información operativa y en paralelo se llevó a cabo una contextualización bibliográfica basada en artículos relacionados. Posteriormente, se identificaron tres factores que impactan sobre la eficiencia del proceso: el desgaste del aislamiento térmico y/o las paredes del equipo, la temperatura y el flujo de la corriente de aire alimentada al sistema. Teniendo en cuenta lo anterior, se establecieron como opciones técnicas de mejora: intervenir el aislamiento térmico; realizar adecuaciones que permitieran ajustar el flujo de aire alimentado e instalar un sistema de calentamiento del aire. Posteriormente, se elaboró un modelo con las condiciones del proceso haciendo uso del software de simulación Aspen HYSYS® que permitió analizar el impacto de las alternativas sobre el sistema para así obtener evidencia de la repercusión de cada alternativa sobre el proceso. Para la primera alternativa se estima un ahorro entre 27 103,44 USD y 51 309,07 USD por año, para la segunda entre 56 856,52 y 73 049,23 USD por año y para la tercera entre 20 899,59 USD y 71 064,14 USD por año.Este estudo técnico foi feito através de uma análise operacional de dois aquecedores de queima direta, a fim de identificar possíveis fatores que impactam sua eficiência. Além disso, possíveis melhorias foram levantadas com base em artigos e informações acadêmicas relacionadas a estas máquinas, de modo a aumentar sua eficiência e diminuir seu consumo de gás. Foram utilizadas duas fontes de informação: a acadêmica e os dados fornecidos pela empresa. Em seguida, as mais importantes foram selecionadas para suscitar alternativas. Três fatores que impactam a eficiência foram identificados: o desgaste do isolamento térmico e/ou de suas paredes, a temperatura e o fluxo de ar que é utilizado no sistema. Com base nas informações selecionadas, três alternativas foram apontadas: verificar e corrigir o isolamento térmico, ajustar o fluxo de ar e instalar um sistema de pré-aquecimento para aumentar a temperatura do ar. Posteriormente, uma simulação do processo foi feita no Aspen HYSYS ® para analisar o impacto das alternativas sobre a eficiência. Finalmente, foram obtidas evidências do impacto sobre o consumo de gás. A primeira alternativa poderia economizar entre $27 103,44/ano e$ 51 309,07/ano, a segunda entre $56 856,52 e$ 73 049,23/ano e a terceira entre $20 899,59/ano e$ 71 064,14/ano.This technical study consists of an operational analysis of two direct fired heaters in order to identify possible factors impacting their efficiency. Furthermore, possible improvements were raised based on articles and academic information related to these machines in order to increase their efficiency and decrease their gas consumption. Two sources of information were used: the academic one and the data provided by the company. Then, they were filtered to choose the most important of them and raise the alternatives. Three factors that impact the efficiency were identified; wear of the thermal isolation and/or their walls, the temperature and the flux of the air that is used in the system. Based on the filtered information, three alternatives were raised: check and fix the thermal isolation, adjust the air flux and install a pre-heating system to increase the temperature of the air. Subsequently, a simulation of the process was made on Aspen HYSYS ® to analyze the impact of the alternatives on the efficiency. Finally, evidence of the impact on gas consumption was obtained. The first alternative could save between $27,103.44/y and$51,309.07/y, the second between $56,856.52 and$73,049.23/y and the third one between $20,899.59/y and$71,064.14/

Tailored intracuff pressures

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Mismatch between midline shift and hematoma thickness as a prognostic factor of mortality in patients sustaining acute subdural hematoma.

BACKGROUND: Acute subdural hematoma (ASDH) is a traumatic lesion commonly found secondary to traumatic brain injury. Radiological findings on CT, such as hematoma thickness (HT) and structures midline shift (MLS), have an important prognostic role in this disease. The relationship between HT and MLS has been rarely studied in the literature. Thus, this study aimed to assess the prognostic accuracy of the difference between MLS and HT for acute outcomes in patients with ASDH in a low-income to middle-income country. METHODS: This was a post-hoc analysis of a prospective cohort study conducted in a university-associated tertiary-level hospital in Brazil. The TRIPOD (Transparent Reporting of a multivariable prediction model for Individual Prognosis or Diagnosis) statement guidelines were followed. The difference values between MLS and HT (Zumkeller index, ZI) were divided into three categories (3). Logistic regression analyses were performed to reveal the OR of categorized ZI in predicting primary outcome measures. A Cox regression was also performed and the results were presented through HR. The discriminative ability of three multivariate models including clinical and radiological variables (ZI, Rotterdam score, and Helsinki score) was demonstrated. RESULTS: A total of 114 patients were included. Logistic regression demonstrated an OR value equal to 8.12 for the ZI >3 category (OR 8.12, 95% CI 1.16 to 40.01; p=0.01), which proved to be an independent predictor of mortality in the adjusted model for surgical intervention, age, and Glasgow Coma Scale (GCS) score. Cox regression analysis demonstrated that this category was associated with 14-day survival (HR 2.92, 95% CI 1.38 to 6.16; p=0.005). A multivariate analysis performed for three models including age and GCS with categorized ZI or Helsinki or Rotterdam score demonstrated area under the receiver operating characteristic curve values of 0.745, 0.767, and 0.808, respectively. CONCLUSIONS: The present study highlights the potential usefulness of the difference between MLS and HT as a prognostic variable in patients with ASDH. LEVEL OF EVIDENCE: Level III, epidemiological study

Práticas adotadas para o descarte de resíduos de medicamentos e saneantes domissanitários por alunos da educação básica

The study objective was to obtain information on the practices adopted by the students of the High School of Course technical of Environmental Sanitation and Biotechnology of Cedup Renato Ramos da Silva School, in Lages, SC for the disposal of residues of medicines and household cleaners in their homes. This study was developed by students of scientific initiation of High School (PIBIC/EM). For data collection a semi-structured questionnaire was applied to the students of the respective courses during the period of their classes in the Institution. It was observed that 63% do not have knowledge about the correct procedure of disposal of drug residues and 55.6% still discard the expired drugs in the common trash. Regarding household cleaning products, 90.1% of the participants do not know how to dispose of these residues in their homes, despite frequent use (83.8%). Concerning residues of insecticides, rodenticides and repellents, about 50% of the participants discard the waste in the common bin and 44% do not know how to dispose of these products. Overall, this study showed that High School students from the Environmental Sanitation and Biotechnology technical Course inappropriately dispose of the drug residues and sanitary household products in their homes. Thus, it emphasizes the importance of including the topic about waste management in basic education courses.Este estudo teve como objetivo levantar informações sobre as práticas adotadas pelos alunos de Ensino Médio do Curso técnico em Saneamento Ambiental e Biotecnologia do Cedup Renato Ramos da Silva de Lages, SC para o descarte dos resíduos de medicamentos e saneantes domissanitários em suas residências. O estudo foi desenvolvido por estudantes de iniciação científica do Ensino Médio (PIBIC/EM). Para a coleta de dados foi aplicado um questionário semiestruturado aos alunos do respectivo curso durante o período de suas aulas na Instituição. Observou-se que 63% não têm conhecimento sobre o procedimento correto de descarte dos resíduos de medicamentos e 55,6% ainda fazem o descarte dos medicamentos vencidos em lixeira comum. Com relação aos produtos domissanitários, 90,1% dos participantes desconhecem a forma de descarte desses resíduos em suas residências, apesar do uso frequente (83,8%). Já quanto relação aos resíduos de inseticidas, raticidas e repelentes, cerca de 50% dos participantes descartam os resíduos na lixeira comum e 44% desconhecem a forma de descarte desses produtos. No geral, este estudo mostrou que os estudantes do Ensino Médio do Curso técnico em Saneamento Ambiental e Biotecnologia não descartam adequadamente os resíduos de medicamentos e saneantes domissanitários gerados em seu domicílio. Dessa forma, enfatiza-se a importância da inserção do tema sobre gestão de resíduos nos cursos de formação básica. &nbsp

A Dynamic Interplay of Circulating Extracellular Vesicles and Galectin-1 Reprograms Viral Latency during HIV-1 Infection

Combined Antiretroviral therapy (cART) suppresses HIV replication but fails to eradicate the virus, which persists in a small pool of long-lived latently infected cells. Immune activation and residual inflammation during cART are considered to contribute to viral persistence. Galectins, a family of b-galactoside-binding proteins, play central roles in host-pathogen interactions and inflammatory responses. Depending on their structure, glycan binding specificities and/or formation of distinct multivalent signaling complexes, different members of this family can complement, synergize, or oppose the function of others. Here, we identify a regulatory circuit, mediated by galectin-1 (Gal-1)–glycan interactions, that promotes reversal of HIV-1 latency in infected T cells. We found elevated levels of circulating Gal-1 in plasma from HIV-1-infected individuals, which correlated both with inflammatory markers and the transcriptional activity of the reservoir, as determined by unspliced-RNA (US-RNA) copy number. Proinflammatory extracellular vesicles (EVs) isolated from the plasma of HIV-infected individuals induced Gal-1 secretion by macrophages. Extracellularly, Gal-1 interacted with latently infected resting primary CD41 T cells and J-LAT cells in a glycan-dependent manner and reversed HIV latency via activation of the nuclear factor kB (NF-kB). Furthermore, CD41 T cells isolated from HIV-infected individuals showed increased HIV-1 transcriptional activity when exposed to Gal-1. Thus, by modulating reservoir dynamics, EV-driven Gal-1 secretion by macrophages links inflammation with HIV-1 persistence in cART-treated individuals. IMPORTANCE Antiretroviral therapy has led to a dramatic reduction in HIV-related morbidity and mortality. However, cART does not eradicate the virus, which persists in resting CD41 T cells as the main viral reservoir, consequently requiring lifelong treatment. A major question is how the functional status of the immune system during antiretroviral therapy determines the activity and size of the viral reservoir. In this study, we identified a central role for galectin-1 (Gal-1), a glycan-binding protein released in response to extracellular vesicles (EVs), in modulating the activity of HIV reservoir, thus shaping chronic immune activation in HIV-infected patients. Our work unveils a central role of Gal-1 in linking chronic immune activation and reservoir dynamics, highlighting new therapeutic opportunities in HIV infection.Fil: Rubione, Julia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; ArgentinaFil: Pérez, Paula Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; ArgentinaFil: Czernikier, Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; ArgentinaFil: Duette, Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; ArgentinaFil: Pereyra Gerber, Federico Pehuén. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; ArgentinaFil: Salido, Jimena Patricia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; ArgentinaFil: Fabiano, Martina P.. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; ArgentinaFil: Ghiglione, Yanina Alexandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; ArgentinaFil: Turk, Gabriela Julia Ana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; ArgentinaFil: Laufer, Natalia Lorna. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; ArgentinaFil: Cagnoni, Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Pérez Sáez, Juan Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Merlo, Joaquín Pedro. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Pascuale, Carla Antonela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; ArgentinaFil: Stupirski, Juan Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Sued, Omar Gustavo. Fundación Huésped; ArgentinaFil: Varas Godoy, Manuel. Universidad San Sebastián; ChileFil: Lewin, Sharon R.. Monash University; Australia. University of Melbourne; AustraliaFil: Mariño, Karina Valeria. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Rabinovich, Gabriel Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Ostrowski, Matias. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentin

On this and other worlds: Voices from Amazonia

This edited volume offers a collection of twelve interlinear texts reflecting the vast linguistic diversity of Amazonia as well as the rich verbal arts and oral literature traditions of Amazonian peoples. Contributions to the volume come from a variety of geographic regions and represent the Carib, Jê, Tupi, East Tukano, Nadahup, and Pano language families, as well as three linguistic isolates. The selected texts exemplify a variety of narrative styles recounting the origins of constellations, crops, and sacred cemeteries, and of travel to worlds beyond death. We hear tales of tricksters and of encounters between humans and other beings, learn of battles between enemies, and gain insight into history and the indigenous perspective of creation, cordiality and confrontation. The contributions to this volume are the result of research efforts conducted since 2000, and as such, exemplify rapidly expanding investment and interest in documenting native Amazonian voices. They moreover demonstrate the collaborative efforts of linguists, anthropologists, and indigenous leaders, storytellers, and researchers to study and preserve Amazonian languages and cultures. Each chapter offers complete interlinear analysis as well as ample commentary on both linguistic and cultural aspects, appealing to a wide audience, including linguists, historians, anthropologists, and other social scientists. This collection is the first of its type, constituting a significant contribution to focused study of Amazonian linguistic diversity and a relevant addition to our broader knowledge of Amerindian languages and cosmologies

On this and other worlds: Voices from Amazonia

This edited volume offers a collection of twelve interlinear texts reflecting the vast linguistic diversity of Amazonia as well as the rich verbal arts and oral literature traditions of Amazonian peoples. Contributions to the volume come from a variety of geographic regions and represent the Carib, Jê, Tupi, East Tukano, Nadahup, and Pano language families, as well as three linguistic isolates. The selected texts exemplify a variety of narrative styles recounting the origins of constellations, crops, and sacred cemeteries, and of travel to worlds beyond death. We hear tales of tricksters and of encounters between humans and other beings, learn of battles between enemies, and gain insight into history and the indigenous perspective of creation, cordiality and confrontation. The contributions to this volume are the result of research efforts conducted since 2000, and as such, exemplify rapidly expanding investment and interest in documenting native Amazonian voices. They moreover demonstrate the collaborative efforts of linguists, anthropologists, and indigenous leaders, storytellers, and researchers to study and preserve Amazonian languages and cultures. Each chapter offers complete interlinear analysis as well as ample commentary on both linguistic and cultural aspects, appealing to a wide audience, including linguists, historians, anthropologists, and other social scientists. This collection is the first of its type, constituting a significant contribution to focused study of Amazonian linguistic diversity and a relevant addition to our broader knowledge of Amerindian languages and cosmologies

On this and other worlds: Voices from Amazonia

This edited volume offers a collection of twelve interlinear texts reflecting the vast linguistic diversity of Amazonia as well as the rich verbal arts and oral literature traditions of Amazonian peoples. Contributions to the volume come from a variety of geographic regions and represent the Carib, Jê, Tupi, East Tukano, Nadahup, and Pano language families, as well as three linguistic isolates. The selected texts exemplify a variety of narrative styles recounting the origins of constellations, crops, and sacred cemeteries, and of travel to worlds beyond death. We hear tales of tricksters and of encounters between humans and other beings, learn of battles between enemies, and gain insight into history and the indigenous perspective of creation, cordiality and confrontation. The contributions to this volume are the result of research efforts conducted since 2000, and as such, exemplify rapidly expanding investment and interest in documenting native Amazonian voices. They moreover demonstrate the collaborative efforts of linguists, anthropologists, and indigenous leaders, storytellers, and researchers to study and preserve Amazonian languages and cultures. Each chapter offers complete interlinear analysis as well as ample commentary on both linguistic and cultural aspects, appealing to a wide audience, including linguists, historians, anthropologists, and other social scientists. This collection is the first of its type, constituting a significant contribution to focused study of Amazonian linguistic diversity and a relevant addition to our broader knowledge of Amerindian languages and cosmologies