Properties of Contextual Memory Formed in the Absence of αCaMKII Autophosphorylation

The alpha-isoform of calcium/calmodulin-dependent kinase II (αCaMKII) is a major synaptic kinase that undergoes autophosphorylation after NMDA receptor activation, switching the kinase into a calcium-independent activity state. This αCaMKII autophosphorylation is essential for NMDA receptor-dependent long-term potentiation (LTP), induced by a single tetanus, in hippocampal area CA1 and in neocortex. Furthermore, the αCaMKII autophosphorylation is essential for contextual long-term memory (LTM) formation after a single training trial but not after a massed training session. Here, we show that in the absence of αCaMKII autophosphorylation contextual fear conditioning is hippocampus dependent and that multi-tetanus-dependent late-LTP cannot be induced in hippocampal area CA1. Furthermore, we show that in the absence of αCaMKII autophosphorylation contextual LTM persists for 30 days, the latest time point tested. Additionally, contextual, but not cued, LTM formation in the absence of αCaMKII autophosphorylation appears to be impaired in 18 month-old mice. Taken together, our findings suggest that αCaMKII autophosphorylation-independent plasticity in the hippocampus is sufficient for contextual LTM formation and that αCaMKII autophosphorylation may be important for delaying age-related impairments in hippocampal memory formation. Furthermore, they propose that NMDA receptor-dependent LTP in hippocampal area CA1 is essential for contextual LTM formation after a single trial but not after massed training. Finally, our results challenge the proposal that NMDA receptor-dependent LTP in neocortex is required for remote contextual LTM

Nerve stimulation of the masseter muscle

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L'ordre de recrutement des unités motrices dans les contractions ballistiques, chez l'homme

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Vitesse de contraction et ordre de recrutement des unités motrices chez l'homme

SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Contribution à l'étude de l'organisation du système moteur chez l'homme

Doctorat en sciences médicalesinfo:eu-repo/semantics/nonPublishe

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Le Mouvement -- 1

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The role of the vestibular commissure in the gaze holding of the cat.

Recent theoretical studies have proposed that the vestibular commissure is a major component of the horizontal gaze-holding system. In order to test this hypothesis, we disrupted the vestibular commissure of the cat by a parasagittal cut running between an abducens nucleus and the adjacent medial vestibular nucleus. Successfully lesioned cats suffered of a characteristic syndrome. In the light, gaze holding was impaired when the animal was looking toward the side of the lesion, but normal when looking toward the opposite side. We conclude (1) that the vestibular commissure is a component of the gaze-holding system, (2) that the vestibular commissure is less essential for gaze holding than other structures as the nucleus prepositus hypoglossi, and (3) that the horizontal gaze-holding system consists of two halves, each being more active in ipsilateral than in contralateral gaze.Journal ArticleResearch Support, Non-U.S. Gov'tinfo:eu-repo/semantics/publishe

The patterning of voluntary commands as revealed by single motor unit studies in man

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Organisation fonctionnelle des commandes motrices volontaires chez l'Homme et caractéristiques particulières aux mouvements ballistiques rapides

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