Distribution and sources of organic matter in surface marine sediments across the North American Arctic margin

As part of the International Polar Year research program, we conducted a survey of surface marine sediments from box cores along a section extending from the Bering Sea to Davis Strait via the Canadian Archipelago. We used bulk elemental and isotopic compositions, together with biomarkers and principal components analysis, to elucidate the distribution of marine and terrestrial organic matter in different regions of the North American Arctic margin. Marked regional contrasts were observed in organic carbon loadings, with the highest values (1 mg C m(-2) sediment) found in sites along Barrow Canyon and the Chukchi and Bering shelves, all of which were characterized by sediments with low oxygen exposure, as inferred from thin layers (\u3c2 \u3ecm) of Mn oxihydroxides. We found strong regional differences in inorganic carbon concentrations, with sites from the Canadian Archipelago and Lancaster Sound displaying elevated values (2-7 wt %) and highly depleted C-14 compositions consistent with inputs from bedrock carbonates. Organic carbon:nitrogen ratios, stable carbon isotopes, and terrigenous organic biomarkers (lignin phenols and cutin acids) all indicate marked regional differences in the proportions of marine and terrigenous organic matter present in surface sediments. Regions such as Barrow Canyon and the Mackenzie River shelf were characterized by the highest contributions of land-derived organic matter, with compositional characteristics that suggested distinct sources and provenance. In contrast, sediments from the Canadian Archipelago and Davis Strait had the smallest contributions of terrigenous organic matter and the lowest organic carbon loadings indicative of a high degree of post-depositional oxidation

Distribution and sources of organic matter in surface marine sediments across the North American Arctic margin

As part of the International Polar Year research program, we conducted a survey of surface marine sediments from box cores along a section extending from the Bering Sea to Davis Strait via the Canadian Archipelago. We used bulk elemental and isotopic compositions, together with biomarkers and principal components analysis, to elucidate the distribution of marine and terrestrial organic matter in different regions of the North American Arctic margin. Marked regional contrasts were observed in organic carbon loadings, with the highest values (1 mg C m(-2) sediment) found in sites along Barrow Canyon and the Chukchi and Bering shelves, all of which were characterized by sediments with low oxygen exposure, as inferred from thin layers (<2 cm) of Mn oxihydroxides. We found strong regional differences in inorganic carbon concentrations, with sites from the Canadian Archipelago and Lancaster Sound displaying elevated values (2-7 wt %) and highly depleted C-14 compositions consistent with inputs from bedrock carbonates. Organic carbon:nitrogen ratios, stable carbon isotopes, and terrigenous organic biomarkers (lignin phenols and cutin acids) all indicate marked regional differences in the proportions of marine and terrigenous organic matter present in surface sediments. Regions such as Barrow Canyon and the Mackenzie River shelf were characterized by the highest contributions of land-derived organic matter, with compositional characteristics that suggested distinct sources and provenance. In contrast, sediments from the Canadian Archipelago and Davis Strait had the smallest contributions of terrigenous organic matter and the lowest organic carbon loadings indicative of a high degree of post-depositional oxidation.Keywords: Arctic margins, sedimentary organic matter, radiocarbon, organic biomarker

THE CONCISE GUIDE TO PHARMACOLOGY 2019/20 : G protein- coupled receptors

The Concise Guide to PHARMACOLOGY 2019/20 is the fourth in this series of biennial publications. The Concise Guide provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide represents approximately 400 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point-in-time record that will survive database updates. The full contents of this section can be found at http://onlinelibrary.wiley.com/doi/10.1111/bph.14748. G protein-coupled receptors are one of the six major pharmacological targets into which the Guide is divided, with the others being: ion channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid-2019, and supersedes data presented in the 2017/18, 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the International Union of Basic and Clinical Pharmacology Committee on Receptor Nomenclature and Drug Classification (NC-IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate.Peer reviewe

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein-coupled receptors

The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide constitutes over 500 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point-in-time record that will survive database updates. The full contents of this section can be found at http://onlinelibrary.wiley.com/doi/bph.15538. G protein-coupled receptors are one of the six major pharmacological targets into which the Guide is divided, with the others being: ion channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid-2021, and supersedes data presented in the 2019/20, 2017/18, 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature and Standards Committee of the International Union of Basic and Clinical Pharmacology (NC-IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein-coupled receptors.

The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide constitutes over 500 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point-in-time record that will survive database updates. The full contents of this section can be found at http://onlinelibrary.wiley.com/doi/bph.15538. G protein-coupled receptors are one of the six major pharmacological targets into which the Guide is divided, with the others being: ion channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid-2021, and supersedes data presented in the 2019/20, 2017/18, 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature and Standards Committee of the International Union of Basic and Clinical Pharmacology (NC-IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate

The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors.

peer reviewedThe Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and about 6000 interactions with about 3900 ligands. There is an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (https://www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide constitutes almost 500 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point-in-time record that will survive database updates. The full contents of this section can be found at http://onlinelibrary.wiley.com/doi/bph.16177. G protein-coupled receptors are one of the six major pharmacological targets into which the Guide is divided, with the others being: ion channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid-2023, and supersedes data presented in the 2021/22, 2019/20, 2017/18, 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature and Standards Committee of the International Union of Basic and Clinical Pharmacology (NC-IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate

Mineralization of organic matter in boreal lake sediments: rates, pathways, and nature of the fermenting substrates

The complexity of organic matter (OM) degradation mechanisms represents a significant challenge for developing biogeochemical models to quantify the role of aquatic sediments in the climate system. The common representation of OM by carbohydrates formulated as CH2O in models comes with the assumption that its degradation by fermentation produces equimolar amounts of methane (CH4) and dissolved inorganic carbon (DIC). To test the validity of this assumption, we modelled using reaction-transport equation vertical profiles of the concentration and isotopic composition (δ13C) of CH4 and DIC in the top 25 cm of the sediment column from two lake basins, one whose hypolimnion is perennially oxygenated and one with seasonal anoxia. Furthermore, we modelled solute porewater profiles reported in the literature for four other seasonally anoxic lake basins. A total of 17 independent porewater datasets are analyzed. CH4 and DIC production rates associated with methanogenesis at the five seasonally anoxic sites collectively show that the fermenting OM has a mean (± SD) carbon oxidation state (COS) value of −1.4±0.3 . This value is much lower than the value of zero expected from carbohydrate fermentation. We conclude that carbohydrates do not adequately represent the fermenting OM in hypolimnetic sediments and propose to include the COS in the formulation of OM fermentation in models applied to lake sediments to better quantify sediment CH4 outflux. This study highlights the potential of mass balancing the products of OM mineralization to characterize labile substrates undergoing fermentation in sediments.publishedVersio

Rapports de pratique de Québec = Quebec practice reports

Published: Montréal : Wilson & Lafleur, 19 -1982Binder's title, [1897/1898]-1973: Quebec practice reportsTitle in French only, 1945-1982Vols. for [1897/1898]-1944 called v. 1-48Mode of access: Internet.Signature of Chs. Ed. Gobeil on fly leaves of v. 1-24Cover of 1st issue lacking; title from captionFOR COMPLETE RECORD SEE CHECKLIS