\u3ci\u3eSale\u27s brigade in Afghanistan: with an account of the seisure and defence of Jellalabad\u3c/i\u3e

Afghanistan, its geographical position, climate and productions -- Outline of Afghan history -- Early negotiations with Afghanistan, preparations for its invasion -- Passage of the Indus, march upon Candahar -- March upon Ghuznee, capture of the place, march on Cabul -- Breaking-up of the army of the Indus, the unquiet state of Afghanistan, surrender of Dost Mohammed -- Peaceful occupation of Cabul and the posts adjacent -- Peaceful occupations at Cabul -- March of Sale\u27s Brigade towards the provinces, operations at Bootkak -- Night attacks on the 35th, advance of the 13th to rejoin their comrades -- March to Tizeen, affair in the valley -- March from Tizeen, rear-guard engaged -- March to Gundamuck, smart affair with the rear-guard -- Bad tidings from Cabul, march, arrival in Camp of unlooked-for visitors, sharp action, approach Jellalabad -- Jellalabad, conflagrations at night, sortie in the morning -- Continuance of the blockade -- Bad news, arrival of Dr. Brydon, his narrative -- Continued preparations for defence, construction of corn-mills, earthquake -- Siege continued, sortie -- Battle of the 7th of April, fall of Colonel Dennie -- Arrival of Pollock\u27s army, sickness in camp -- Advance of Pollock\u27s army to Cabul -- Evacuation of Afghanistan

Enlightenment After the Enlightenment: American Transformations of Asian Contemplative Traditions

My dissertation traces the contemporary American assimilation of Asian enlightenment traditions and discourses. Through a close reading of three communities, I consider how Asian traditions and ideas have been refracted through the psychological, political, and economic lenses of American culture. One of my chapters, for example, discusses how the American Insight community has attempted to integrate the enlightenment teachings of Theravada Buddhism with the humanistic, democratic, and pluralistic values of the European Enlightenment. A second chapter traces the American gum Andrew Cohen's transformation from a Neo-Advaita teacher to a leading proponent of "evolutionary enlightenment," a teaching that places traditional Indian understandings of nonduality in an evolutionary context. Cohen's early period shows the further deinstitutionalization of traditional Advaita Vedanta within the radically decontextualized Neo-Advaitin network, and evolutionary enlightenment engages and popularizes another less-known but influential Hindu lineage, namely that of Sri Aurobindo's integral yoga. a A third chapter examines contemporary psychospiritual attempts to incorporate psychoanalytic theory into Asian philosophy in order to reconcile American concerns with individual development with Asian mystical goals of self-transcendence. In conclusion, I argue that the contemporary American assimilation of Asian enlightenment traditions is marked by a number of trends including: (I) a move away from the rhetoric and privileging of experience that scholars such as Robert Sharf have shown to be characteristic of the modem Western understanding of Asian mysticism; and (2) an embrace of world-affirming Tantric forms of Asian spirituality over world-negating renouncer traditions such as Theravada Buddhism and Advaita Vedanta. I also reflect on how the cultural shift from the modem to postmodern has affected East-West integrative spiritualities

Chromosomal radiosensitivity in G2-phase lymphocytes identifies breast cancer patients with distinctive tumour characteristics

A substantial proportion of women with breast cancer exhibit an abnormally high radiosensitivity as measured by the frequency of chromatid breaks induced in G2-phase, PHA stimulated lymphocytes. Chromatid break frequencies were compared for a cohort of previously untreated sporadic breast cancer patients and hospital outpatient controls. In the breast cancer group 46% showed high radiosensitivity compared to 14% of controls (P< 0.001). Comparison of those breast cancer patients with a high G2radiosensitivity (G2RS) versus those with a low G2RS showed no difference in menopausal status or age but the high G2RS group had on average a lower score on the Nottingham Prognostic Index. Predicted survival in the high G2RS group at 15 years was 55% compared to 36% for the low G2RS group. Furthermore, 81% of tumours from the high G2RS were oestrogen receptor positive compared to 45% from the low G2RS group. Thus high G2RS identifies a sub-population of patients with distinctive tumour characteristics and with a predicted improved prognosis as compared with those in the low G2RS group. Our findings imply that besides influencing risk of breast cancer the genetic factors determining G2radiosensitivity also influence the tumour characteristics and prognosis in these patients. © 2001 Cancer Research Campaign  http://www.bjcancer.co

Religion as practices of attachment and materiality: the making of Buddhism in contemporary London

This article aims to explore Buddhism’s often-overlooked presence on London’s urban landscape, showing how its quietness and subtlety of approach has allowed the faith to grow largely beneath the radar. It argues that Buddhism makes claims to urban space in much the same way as it produces its faith, being as much about the practices performed and the spaces where they are enacted as it is about faith or beliefs. The research across a number of Buddhist sites in London reveals that number of people declaring themselves as Buddhists has indeed risen in recent years, following the rise of other non-traditional religions in the UK; however, this research suggests that Buddhism differs from these in several ways. Drawing on Baumann’s (2002) distinction between traditionalist and modernist approaches to Buddhism, our research reveals a growth in each of these. Nevertheless, Buddhism remains largely invisible in the urban and suburban landscape of London, adapting buildings that are already in place, with little material impact on the built environment, and has thus been less subject to contestation than other religious movements and traditions. This research contributes to a growing literature which foregrounds the importance of religion in making contemporary urban and social worlds

Level of agreement between frequently used cardiovascular risk calculators in people living with HIV

Objectives The aim of the study was to describe agreement between the QRISK2, Framingham and Data Collection on Adverse Events of Anti‐HIV Drugs (D:A:D) cardiovascular disease (CVD) risk calculators in a large UK study of people living with HIV (PLWH). Methods PLWH enrolled in the Pharmacokinetic and Clinical Observations in People over Fifty (POPPY) study without a prior CVD event were included in this study. QRISK2, Framingham CVD and the full and reduced D:A:D CVD scores were calculated; participants were stratified into ‘low’ ( 20%) categories for each. Agreement between scores was assessed using weighted kappas and Bland–Altman plots. Results The 730 included participants were predominantly male (636; 87.1%) and of white ethnicity (645; 88.5%), with a median age of 53 [interquartile range (IQR) 49–59] years. The median calculated 10‐year CVD risk was 11.9% (IQR 6.8–18.4%), 8.9% (IQR 4.6–15.0%), 8.5% (IQR 4.8–14.6%) and 6.9% (IQR 4.1–11.1%) when using the Framingham, QRISK2, and full and reduced D:A:D scores, respectively. Agreement between the different scores was generally moderate, with the highest level of agreement being between the Framingham and QRISK2 scores (weighted kappa = 0.65) but with most other kappa coefficients in the 0.50–0.60 range. Conclusions Estimates of predicted 10‐year CVD risk obtained with commonly used CVD risk prediction tools demonstrate, in general, only moderate agreement among PLWH in the UK. While further validation with clinical endpoints is required, our findings suggest that care should be taken when interpreting any score alone

Depression, lifestyle factors and cognitive function in people living with HIV and comparable HIV-negative controls

We investigated whether differences in cognitive performance between people living with HIV (PLWH) and comparable HIV-negative people were mediated or moderated by depressive symptoms and lifestyle factors. METHODS: A cross-sectional study of 637 'older' PLWH aged ≥ 50 years, 340 'younger' PLWH aged < 50 years and 276 demographically matched HIV-negative controls aged ≥ 50 years enrolled in the Pharmacokinetic and Clinical Observations in People over Fifty (POPPY) study was performed. Cognitive function was assessed using a computerized battery (CogState). Scores were standardized into Z-scores [mean = 0; standard deviation (SD) = 1] and averaged to obtain a global Z-score. Depressive symptoms were evaluated via the Patient Health Questionnaire (PHQ-9). Differences between the three groups and the effects of depression, sociodemographic factors and lifestyle factors on cognitive performance were evaluated using median regression. All analyses accounted for age, gender, ethnicity and level of education. RESULTS: After adjustment for sociodemographic factors, older and younger PLWH had poorer overall cognitive scores than older HIV-negative controls (P < 0.001 and P = 0.006, respectively). Moderate or severe depressive symptoms were more prevalent in both older (27%; P < 0.001) and younger (21%; P < 0.001) PLWH compared with controls (8%). Depressive symptoms (P < 0.001) and use of hashish (P = 0.01) were associated with lower cognitive function; alcohol consumption (P = 0.02) was associated with better cognitive scores. After further adjustment for these factors, the difference between older PLWH and HIV-negative controls was no longer significant (P = 0.08), while that between younger PLWH and older HIV-negative controls remained significant (P = 0.01). CONCLUSIONS: Poorer cognitive performances in PLWH compared with HIV-negative individuals were, in part, mediated by the greater prevalence of depressive symptoms and recreational drug use reported by PLWH

Behaviour of long structures in response to tunnelling

This paper presents observations of the response of long structures when exposed to tunnelling activities in London Clay. The type of structures varied from a 100 years old masonry arch tunnel to a more modern reinforced concrete frame structure. The common property shared by these structures is that they are long in comparison to the depth beneath them of the tunnels being constructed. Numerical analyses have also been carried out to back analyse the observed data using the London Clay soil parameters. The model was then extended to include a depth and a structural stiffness variable and demonstrate sensitivity to those factors

Advocacy and IPR, tutorial 4

With open access and repositories assuming a high profile some may question whether advocacy is still necessary. Those involved in the business of setting up and populating repositories are aware that in the majority of institutions there is still a great need for advocacy. This tutorial will give participants an opportunity to discuss different advocacy methods and approaches, including the 'top down' and 'bottom up' approach, publicity methods and the opportunities offered by funding body positions on open access. Participants will have the opportunity to share experiences of what works and what doesn't. The advocacy role often encompasses responsibility for advising academics on IPR issues. This is a particularly critical area where repository staff are engaged in depositing content on behalf of academics. The tutorial will offer an opportunity to discuss the IPR issues encountered by those managing repositories. The tutorial will draw on the experience of participants who have been engaged in advocacy activities for some time. The tutorial should be particularly useful for those new to the area, but it will also present an opportunity for sharing ideas