THE NUTRITIONAL ROLE OF VITAMIN D DURING THE SARS COVID-19 PANDEMIC

The supplementary intake of vitamin D is one of the most debated topics in the medical field, a source of controversy and convictions that are also strongly antithetical. Both the judgment of clinicians and public opinion consider this vitamin necessary for the maintenance of bone health, but also for the prevention and treatment of a number of diseases, including diabetes mellitus, autoimmune diseases, neoplasms, multiple sclerosis, heart disease, stroke, depression and more association between low levels of serum 25-hydroxyvitamin D. In fact, Vitamin D is responsible for regulation of calcium and phosphate metabolism and maintaining a healthy mineralized skeleton. It is also known as an immunomodulatory hormone. Experimental studies have shown that 1,25-dihydroxyvitamin D, the active form of vitamin D, exerts immunologic activities on multiple components of the innate and adaptive immune system as well as endothelial membrane stability. Association between low levels of serum 25-hydroxyvitamin D. Vitamin D plays a fundamental role in nutrition, especially for the new evidence related to the SARS pandemic Covid-19 and for this reason it is important to maintain optimal levels of the vitamin, controlled through food

LYCOPENE AND THE ROLE IN METABOLIC PREVENTION

The origin of the tomato plant seems to be South America, in particular Chile and Ecuador, where it grows as a wild plant due to the tropical climate and is able to bear fruit throughout the year, while in European regions, if cultivated in 'open, has a seasonal cycle limited to the summer period. From here, it later spread to Central America and it was the Spaniards who made it known in Europe in the 16th century. Only at the end of the 18th century, the cultivation of tomatoes for food purposes experienced a strong boost in Europe, mainly in France and Southern Italy. Starting from the 19th century, the tomato was finally included in European gastronomic treaties, favoring a conspicuous diffusion both on the tables of the richest and those of the less well-off. Today tomatoes are a staple of our diet a series of researches have identified the effects that the consumption of this particular food, in its many variations, has on our health. If previously the effects that tomatoes have on the improvement of blood lipids were recognized, now researchers have identified a direct correlation between the risk of cardiovascular mortality and the consumption of the fruit, for the presence of Lycopene, a carotenoid antioxidant. It is lycopene, in particular, that produces the greatest benefits for our body. It is a powerful antioxidant that determines, among other things, the particular red color of the tomato. Through research on the effects of a diet rich in tomatoes on the body, the experts found a progressive decrease in the concentration of cholesterol accompanied by a decrease in cardiovascular risk

HEALTH PROPERTIES OF LYCOPERSICUM ESCULENTUM

The tomato, Lycopersicum esculentum, is a horticultural plant belonging to the Solanaceae family. In Italy, the term "tomato" is found for the first time in the famous "Herbarius" by Pietro Mattioli. The etymology of the name leads back to the Latin "pomum aureus", apple or golden apple. Unlike in other languages, such as English, the term "tomato" is linked to the etymology of the Aztec version "Xitotomate". The origin of the tomato plant seems to be South America, in particular Chile and Ecuador, where it grows as a wild plant due to the tropical climate and is able to bear fruit throughout the year, while in European regions, if cultivated in 'open, has a seasonal cycle limited to the summer period. From here, it later spread to Central America and it was the Spaniards who made it known in Europe in the 16th century. The cultivation of the tomato plant was already widespread in the pre-Columbian age, when it was used as an ornamental plant and was not used in the kitchen: this is because the tomato was considered poisonous due to its high content in solanine, a substance considered harmful for the 'man. In 1544, the Italian herbalist Pietro Mattioli classified the tomato plant among the poisonous species. It is not clear when the tomato, as an ornamental and poisonous plant, was considered edible by Europeans; it should be noted that not even the inhabitants of South America ate the fruits of the plant. From Europe, or perhaps more precisely from Spain, the tomato plant landed in Morocco, where it found an ideal climate, and from there it spread throughout the Mediterranean basin. Starting from the seventeenth century, in southern Europe, as well as in Bohemia and England, the tomato began to be used fresh and for the preparation of sauces, while its diffusion as a food in northern Europe encountered many difficulties, perhaps due to the presence of other similar wild plants which, due to their high alkaloid content, were not suitable for food consumption. Only at the end of the 18th century, the cultivation of tomatoes for food purposes experienced a strong boost in Europe, mainly in France and Southern Italy. Starting from the 19th century, the tomato was finally included in European gastronomic treaties, favoring a conspicuous diffusion both on the tables of the richest and those of the less well-off

Multidrug Resistance (MDR): A Widespread Phenomenon in Pharmacological Therapies

Multidrug resistance is a leading concern in public health. It describes a complex phenotype whose predominant feature is resistance to a wide range of structurally unrelated cytotoxic compounds, many of which are anticancer agents. Multidrug resistance may be also related to antimicrobial drugs, and is known to be one of the most serious global public health threats of this century. Indeed, this phenomenon has increased both mortality and morbidity as a consequence of treatment failures and its incidence in healthcare costs. The large amounts of antibiotics used in human therapies, as well as for farm animals and even for fishes in aquaculture, resulted in the selection of pathogenic bacteria resistant to multiple drugs. It is not negligible that the ongoing COVID‐19 pandemic may further contribute to antimicrobial resistance. In this paper, multidrug resistance and antimicrobial resistance are underlined, focusing on the therapeutic options to overcome these obstacles in drug treatments. Lastly, some recent studies on nanodrug delivery systems have been reviewed since they may represent a significant approach for overcoming resistance

Vitamin d in the prevention, development and therapy of oncological diseases

Vitamin D, traditionally known as a fat-soluble essential vitamin, is a precursor of a powerful steroid hormone that regulates a broad spectrum of physiological processes. In addition to its fundamental role in bone metabolism, epidemiological, preclinical and cellular researches in recent decades have revealed that vitamin D can play a considerable role in the prevention of some pathologies, including extra-skeletal ones, such as neoplasms. Vitamin D, as a prohormone, undergoes first hepatic and subsequently renal metabolism to produce a biologically active metabolite, calcitriol or 1α,25-dihydroxyvitamin D or (1,25 (OH)2D), which binds the vitamin D receptor by regulating the expression of several genes involved in bone metabolism and other biological functions. Furthermore, recent studies have revealed that vitamin D can be also metabolized and activated through a non-canonical metabolic pathway catalyzed by CYP11A1, the gene encoding the cholesterol side chain cleavage enzyme or P450scc. The metabolites of vitamin D deriving from the CYP11A1 enzyme have shown antiproliferative and anti-inflammatory activities and are able to promote the differentiation process on neoplastic cells in comparable way or better than calcitriol, thus contributing to its tumor preventive effect. Clinical data have demonstrated that vitamin D has anticancer activity against prostate, colon, and breast cancers. Several molecular mechanisms of vitamin D involved in tumor etiopathogenesis have been proposed that have not yet been fully clarified. Vitamin D may play a key role in preventing the early stage of the neoplastic process by exerting anti-inflammatory, antioxidant defenses and inducing enzymes responsible for repairing DNA damage and could also be involved in mechanisms of inhibition of cell proliferation, induction of cell differentiation, and cell death. In addition, some studies indicate various mechanisms through which vitamin D can quantitatively and qualitatively influence the intestinal microbiota, strongly linked to chronic inflammatory bowel diseases and the development of colon cancer. However, the metabolism and functions of vitamin D are dysregulated in some neoplasms which therefore develop resistance to the antiproliferative effect of vitamin D, and this promotes tumor development and progression. In this review, studies regarding vitamin D in relation to its activity in cancer have been summarized, as long as the metabolic pathways described for vitamin D

New piperazine and morpholine derivatives: Mass spectrometry characterization and evaluation of their antimicrobial activity

: Recently, pharmaceutical research has been focused on the design of new antibacterial drugs with higher selectivity towards several strains. Major issues concern the possibility to obtain compounds with fewer side effects, at the same time effectively overcoming the problem of antimicrobial resistance. Several solutions include the synthesis of new pharmacophores starting from piperazine or morpholine core units. Mass spectrometry-based techniques offer important support for the structural characterization of newly synthesized compounds to design safer and more effective drugs for various medical conditions. Here, two new piperazine derivatives and four new morpholine derivatives were synthesized and structurally characterized through a combined approach of Fourier transform-ion cyclotron resonance (FT-ICR) and Linear Trap Quadrupole (LTQ) mass spectrometry. The support of both high-resolution and low-resolution mass spectrometric data namely accurate mass measurements, isotopic distribution and MSn spectra, was crucial to confirm the success of the synthesis. These compounds were further evaluated for inhibitory activity against a total of twenty-nine Gram-positive and Gram-negative bacteria to determine the action spectrum and the antimicrobial effectiveness. Results demonstrated compounds' antimicrobial activity against many tested bacterial species, providing an inhibitory effect linked to different chemical structure and suggesting that the new-synthesized derivatives could be considered as promising antimicrobial agents

Low‐carbon transition risks for finance

The transition to a low‐carbon economy will entail a large‐scale structural change. Some industries will have to expand their relative economic weight, while other industries, especially those directly linked to fossil fuel production and consumption, will have to decline. Such a systemic shift may have major repercussions on the stability of financial systems, via abrupt asset revaluations, defaults on debt, and the creation of bubbles in rising industries. Studies on previous industrial transitions have shed light on the financial transition risks originating from rapidly rising “sunrise” industries. In contrast, a similar conceptual understanding of risks from declining “sunset” industries is currently lacking. We substantiate this claim with a critical review of the conceptual and historical literature, which also shows that most literature either examines structural change in the real economy, or risks to financial stability, but rarely both together. We contribute to filling this research gap by developing a consistent theoretical framework of the drivers, transmission channels, and impacts of the phase‐out of carbon‐intensive industries on the financial system and on the feedback from the financial system into the rest of the economy. We also review the state of play of policy aiming to protect the financial system from transition risks and spell out research implications