Role of the irrigation charges to induce the adoption of water saving innovation in semi-arid regions

The paper investigates about the effectiveness of water charges in inducing farmers to adopt the technical innovation aimed at water saving. It is claimed that by increasing water charge, the signal of the scarcity of the water resource is directly and effectively conveyed to farmers, who are supposed to promptly react by adopting a water saving technology. The analysis is referred to two types of innovation: an agronomic innovation, consisting on a crop mulching practice, and a management innovation, based on a voluntarily water pricing scheme with tariffs differentiated according to a peak and off-peak season. A theoretical model based on farms’ profit maximization is proposed, to evaluate the trigger conditions for the innovation. The model is applied to a case study referred to a semi-arid region, located in the South of Italy, according to which there is no clear evidence that a generalized increase may induce farmers to adopt the innovatio

Irrigation pricing policy aimed at the enhancement of water saving innovation at farm level. A case study

In this study we analyze the price inducement effect of a generalized water tariff increase in the adoption of water saving innovation at farm level. We apply a linear programming decision making model to analyze the determinants affecting the adoption of two types of innovation: a process innovation, consisting on a crop mulching practice, and a management innovation, based on a voluntary water seasonal pricing scheme, differentiated according to a peak and off-peak periods. According to our results, the mulching practice is not affected by the tariffs that are still lower than the water marginal productivity, while they exert a negative effect when they become higher. On the contrary, the adoption of the voluntary water seasonal pricing scheme is affected by the tariffs increase only if the latter induce an excessive concentration of water demand during the peakDans cette étude nous présentons une recherche relative à la possibilité que l augmentation de tarif de l eau est capable d induire l agriculteur de adopter une innovation adressée à l épargne de l eau. Notre modèle de programmation linéaire nous a permis de analyser le procès de décision de l agriculteur et d entendre les causes déterminantes de l adoption de deux typologies d innovation: une innovation de procès, relative à une technique de paillis, et une innovation de management, relative à l introduction d un plan volontaire, avec des tarifs différentes entre les periodes de intense et de normale utilisation de l eau. Nos résultats montre que l augmentation de tarif de l eau n est pas une mesure sufficiente pour stimuler les agriculteurs à adopter la technique de paillis, lorsque le tarif de l eau est inférieur à sa productivité marginale. Ou contraire, quand le tarif est plus grand que la productivité marginale de l eau, l augmentation de tarif freine l adoption de l innovation. L introduction des tarifs différentes entre les periodes de intense ed de normale utilisation de l eau est encouragée par l augmentation de tarif seulement quand la demande de l eau est plus concentrée dans la la periode de intense utilisation de l ea

A novel mutation in isoform 3 of the plasma membrane Ca2+ pump impairs cellular Ca2+ homeostasis in a patient with cerebellar ataxia and laminin subunit 1\u3b1 mutations.

The particular importance of Ca2+ signaling to neurons demands its precise regulation within their cytoplasm. Isoform 3 of the plasma membrane Ca2+ ATPase (the PMCA3 pump), which is highly expressed in brain and cerebellum, plays an important role in the regulation of neuronal Ca2+. A genetic defect of the function of the PMCA3 pump has been described in one family with X-linked congenital cerebellar ataxia. Here we describe a novel mutation of the PMCA3 pump (ATP2B3) in a patient with global developmental delay, generalized hypotonia and cerebellar ataxia. The mutation (a R482H replacement) impairs the Ca2+ ejection function of the pump. It reduces the ability of the pump expressed in model cells to control Ca2+ transients generated by cell stimulation and impairs its Ca2+ extrusion function under conditions of low resting cytosolic Ca2+ as well. In silico analysis of the structural effect of the mutation suggests a reduced stabilization of the portion of the pump surrounding the mutated residue in the Ca2+-bound state. The patient also carries two missense mutations in LAMA1, encoding for laminin subunit 1\u3b1. On the basis of the family pedigree of the patient, the presence of both PMCA3 and LAMA1 mutations appears to be necessary for the development of the disease. Considering the observed defect in cellular Ca2+ homeostasis and the previous finding that PMCAs act as digenic modulators in Ca2+-linked pathologies, the PMCA3 dysfunction along with LAMA1 mutations could act synergistically to cause the neurological phenotype

Relationship between microstructure, mechanical and magnetic properties of pure iron produced by laser powder bed fusion (L-PBF) in the as-built and stress relieved conditions

In the present work, the mechanical and magnetic properties of pure iron manufactured by laser-powder bed fusion (L-PBF) were investigated both in the as-built (AB) and stress relieved (HT) conditions, with the aim of elucidating their relationship with the microstructure and evaluating whether and to what extent it can be suitable for industrial applications. The L-PBF process was optimized to obtain high density, crack-free components. Specimens for microstructural analyses, tensile and magnetic tests were manufactured under the optimized conditions and tested both in the as-built and annealed (850 degrees C for 1 h, to relieve the residual stresses) conditions. Tensile tests showed high tensile strength in both AB and HT conditions (larger than those of conventionally produced pure iron), with higher ductility and lower strength after stress relieving. The magnetic study indicated a not optimal magnetic softness although the heat treatment enhanced the permeability and reduced the coercivity with respect to the as-built condition. The high mechanical strength and low magnetic softness came from the very fine grain size (about 5 mu m) of L-PBF pure iron. Instead, the improvement of magnetic softness and ductility after heat treatment was attributed to the possible reduction of dislocation density and consequent stress relief. The results indicated the possibility to achieve a considerably high mechanical strength, in pure iron manufactured by L-PBF, although the fine grain size limits its magnetic softness

A Fondazione Italiana Linfomi cohort study of R-COMP vs R-CHOP in older patients with diffuse large B-cell lymphoma

: Rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) is the most commonly used regimen for the upfront treatment of diffuse large B-cell lymphoma (DLBCL). However, it is associated with cardiotoxicity, especially in older patients. Substituting doxorubicin with non-PEGylated liposomal doxorubicin (R-COMP) may reduce the risk of cardiac events, but its efficacy has never been demonstrated in prospective trials. We describe the characteristics and outcome of patients with DLBCL aged ≥65 years prospectively enrolled in the Elderly Project by the Fondazione Italiana Linfomi and treated with full doses of R-CHOP or R-COMP per local practice. Starting from 1163 patients, 383 (55%) were treated with R-CHOP and 308 (45%) with R-COMP. Patients treated with R-COMP were older (median age, 76 vs 71 years), less frequently fit at simplified geriatric assessment (61% vs 88%; P < .001), and had a more frequent baseline cardiac disorders (grade >1, 32% vs 8%; P < .001). Three-year progression-free survival (PFS) was similar between R-CHOP and R-COMP (70% and 64%); 3-year overall survival was 77%, and 71% respectively. R-CHOP was associated with better PFS vs R-COMP only in the Elderly Prognostic Index (EPI) low-risk group. The two groups had similar rates of treatment interruptions due to toxicities or of cardiac events (P = 1.00). We suggest R-COMP is a potentially curative treatment for older patients with intermediate- or high-risk EPI, even in the presence of a baseline cardiopathy. R-CHOP is confirmed as the standard therapy for low risk patients

MYC Rearranged Aggressive B-Cell Lymphomas: A Report on 100 Patients of the Fondazione Italiana Linfomi (FIL)

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Diffuse large B-cell lymphoma in octogenarians aged 85 and older can benefit from treatment with curative intent: a report on 129 patients prospectively registered in the Elderly Project of the Fondazione Italiana Linfomi (FIL)

Octogenarian patients with diffuse large B-cell lymphoma are managed mainly with palliation, but recent improvement in their overall condition makes potentially curative treatment a possibility. Studies have shown that half of selected octogenarians may be cured using reduced-dose anthracycline chemoimmunotherapy. However, patients aged >85 (late octogenarians [LO]) were underrepresented, and selection criteria were poorly defined. We analyzed the clinical characteristics and outcomes of LO enrolled in the FIL Elderly Project in terms of the treatment received (palliative vs. curative) and of their simplified geriatric assessment (sGA), then compared them with early octogenarians (EO) aged 80- 84 and with those aged 65-79 classified as UNFIT or FRAIL according to sGA enrolled in the same study. Of the 1,163 patients, 370 were >80 and 129 LO. Clinical characteristics were similar between LO and EO, but LO more frequently received palliation (50% vs. 23%; P=0.001) and had worse 2-year overall survival (OS) (48% vs. 63%; P=0.001) and 2-year progression-free survival (PFS) (43% vs. 56%; P=0.01). Patients receiving anthracycline did better than patients receiving palliation (P<0.001), without any difference between full or reduced doses. Rituximab within palliation improved outcome (2-yr OS with or without rituximab 42% vs. 22%; P=0.008). Elderly Prognostic Index (EPI) performed better than sGA in identifying different risk categories, and high-risk EPI retained an independent unfavorable effect on OS and PFS, together with treatment without anthracycline. In conclusion, late octogenarians can benefit from a curative approach with reduced-dose anthracycline and from rituximab within palliation. EPI may help in patient selection more than sGA can

Intraperitoneal drain placement and outcomes after elective colorectal surgery: international matched, prospective, cohort study

Despite current guidelines, intraperitoneal drain placement after elective colorectal surgery remains widespread. Drains were not associated with earlier detection of intraperitoneal collections, but were associated with prolonged hospital stay and increased risk of surgical-site infections.Background Many surgeons routinely place intraperitoneal drains after elective colorectal surgery. However, enhanced recovery after surgery guidelines recommend against their routine use owing to a lack of clear clinical benefit. This study aimed to describe international variation in intraperitoneal drain placement and the safety of this practice. Methods COMPASS (COMPlicAted intra-abdominal collectionS after colorectal Surgery) was a prospective, international, cohort study which enrolled consecutive adults undergoing elective colorectal surgery (February to March 2020). The primary outcome was the rate of intraperitoneal drain placement. Secondary outcomes included: rate and time to diagnosis of postoperative intraperitoneal collections; rate of surgical site infections (SSIs); time to discharge; and 30-day major postoperative complications (Clavien-Dindo grade at least III). After propensity score matching, multivariable logistic regression and Cox proportional hazards regression were used to estimate the independent association of the secondary outcomes with drain placement. Results Overall, 1805 patients from 22 countries were included (798 women, 44.2 per cent; median age 67.0 years). The drain insertion rate was 51.9 per cent (937 patients). After matching, drains were not associated with reduced rates (odds ratio (OR) 1.33, 95 per cent c.i. 0.79 to 2.23; P = 0.287) or earlier detection (hazard ratio (HR) 0.87, 0.33 to 2.31; P = 0.780) of collections. Although not associated with worse major postoperative complications (OR 1.09, 0.68 to 1.75; P = 0.709), drains were associated with delayed hospital discharge (HR 0.58, 0.52 to 0.66; P &lt; 0.001) and an increased risk of SSIs (OR 2.47, 1.50 to 4.05; P &lt; 0.001). Conclusion Intraperitoneal drain placement after elective colorectal surgery is not associated with earlier detection of postoperative collections, but prolongs hospital stay and increases SSI risk

Exacerbation of paranoid schizophrenia in a psoriatic patient after treatment with cyclosporine A, but not with etanercept.

Psoriasis may be frequently associated with psychiatric diseases. We present a 44-year-old man undergoing cyclosporine therapy for treatment of generalized plaque psoriasis which exacerbated his symptoms of paranoid schizophrenia, and disappeared a few days after discontinuation of cyclosporine. Replacement therapy with etanercept achieved clinical remission of psoriasis without any psychiatric side effects. Systemic medications, such as cyclosporine and etanercept, induce modifications of the cytokine network. This is pathogenetically significant in both psoriasis and psychiatric disorders. This case report suggests that dermatologists need to become more familiar with the risk-benefit of drug-induced cytokines dysregulation in psoriatic patients with comorbid psychiatric disorders