2 research outputs found
The Different Facets of Triclocarban: A Review
In the late 1930s and early 1940s, it was discovered that the substitution on aromatic rings
of hydrogen atoms with chlorine yielded a novel chemistry of antimicrobials. However, within a
few years, many of these compounds and formulations showed adverse effects, including human
toxicity, ecotoxicity, and unwanted environmental persistence and bioaccumulation, quickly leading
to regulatory bans and phase-outs. Among these, the triclocarban, a polychlorinated aromatic
antimicrobial agent, was employed as a major ingredient of toys, clothing, food packaging materials,
food industry floors, medical supplies, and especially of personal care products, such as soaps,
toothpaste, and shampoo. Triclocarban has been widely used for over 50 years, but only recently some
concerns were raised about its endocrine disruptive properties. In September 2016, the U.S. Food and
Drug Administration banned its use in over-the-counter hand and body washes because of its toxicity.
The withdrawal of triclocarban has prompted the efforts to search for new antimicrobial compounds
and several analogues of triclocarban have also been studied. In this review, an examination of
different facets of triclocarban and its analogues will be analyzed