Remembrance Archives

The article proposes a reflection on the design role and a speculative project about the topic of temporality in the digital city. The notion of socio-technical system (Whitworth 2009) is used to show how in a society characterized by high technological density the city model could approach the one of a factory (Armando & Durbiano 2019). In a socio-technical system the capillarity of the interactions between men and machines is central in beating the rhythm of the subjects’ behaviors acting its space. Furthermore in the contemporary landscape the analytics systems producing predictions introduce an additional temporal layer (Hansen 2015) used as a filter to read and design these behaviors (Pentland 2019) and the city planning. Artificial intelligences, synthesizing the data harvested, produce precognition simulating behaviors in the digital in order to anticipate them in the analogical. It is claimed that within these temporal loops only an incremental optimization is possible and that to design exclusively through this filter could cause a folding of time that would lead the city to live in a temporal bubble, whereas the city lives on many different temporal lines contributing to the imagination and to the collective memory (Gregotti 1966). Therefore design has to address this challenge bringing the question of the memory at the project's center (Zannoni 2018). A speculative project called Remembrance Archives is proposed. Remembrance Archives aims to hack the temporal bubble by the injection of data drawn from the past of the city history that will alter the regular output of the artificial intelligence predictive models in unexpected ways, practicing an actual work of remembrance through which people will interact with the city memories as a source of new meanings and imaginar

Places in Lieu. Mediterranean Sedentary and Nomadic Living Spaces

The Mediterranean landscape represents an interface between two different shores, a skin dividing an inner from an outer space, a fullness from a void, which are generated by two symbolic ways of living and construction of space: the space of staying that is sedentary, solid, full and the space of going that is no- madic, fluid, void (Careri, 2006). This research proposes a reflection on how the territory’s surface is invested with meanings, playing the role of link between different languages and means of iden- tity construction (Dal Buono & Scodeller, 2016), thus offering a double overview. On the one hand, on how the nomadic transhumance of several populations affects the creation of a new Mediterranean landscape and on new forms of living the individual and common spaces, which generate a different aesthetics and a new way of experiencing the city time. An unpredictable aesthetics that in some places becomes void, as in the abandoned and depopulated Mediterranean ar- eas, while in others it gets full of new migrants thanks to resettlement measures. The void left by the old inhabitants, abandoned spaces waiting to be repopulated, residues devoid of an apparent function that get new meaning and become shel- ters for diversity (Clément, 2005): for plants, as well as for allochthonous people that driven by force majeure, move from one garden to another, generating a reborn and an increase in the biodiversity hotspots (Clément, 2011). On the other hand, we wish to investigate the role of design in its various facets, methodologies and contemporary tools as a means to foster the relationship be- tween landscape and citizenship, to let them achieve its own identity representa- tion and fill the socio-cultural void of the territory. The project’s practice can be a tool to trigger policies of self-determination of the imaginary, allowing those who live in the territory to be involved in making their own story, according to a sense of belonging when they make a representation of their community (Colafranc- eschi, 2015). Focusing on design actions and multiple case studies – such as urban regenera- tion labs, social cooking, social engaged art and participatory interaction prac- tices through digital media – which have been able to generate and encourage relationships between different cultural, identity and aesthetic aspects of the Mediterranean area, sparking short and long term moments of contemplation, sharing and discussion

The RET/PTC-RAS-BRAF linear signaling cascade mediates the motile and mitogenic phenotype of thyroid cancer cells

In papillary thyroid carcinomas (PTCs), rearrangements of the RET receptor (RET/PTC) and activating mutations in the BRAF or RAS oncogenes are mutually exclusive. Here we show that the 3 proteins function along a linear oncogenic signaling cascade in which RET/PTC induces RAS-dependent BRAF activation and RAS- and BRAF-dependent ERK activation. Adoptive activation of the RET/PTC-RAS-BRAF axis induced cell proliferation and Matrigel invasion of thyroid follicular cells. Gene expression profiling revealed that the 3 oncogenes activate a common transcriptional program in thyroid cells that includes upregulation of the CXCL1 and CXCL10 chemokines, which in turn stimulate proliferation and invasion. Thus, motile and mitogenic properties are intrinsic to transformed thyroid cells and are governed by an epistatic oncogenic signaling cascade

Elotuzumab plus lenalidomide and dexamethasone in relapsed/refractory multiple myeloma: Extended 3-year follow-up of a multicenter, retrospective clinical experience with 319 cases outside of controlled clinical trials

The combination of elotuzumab, lenalidomide, and dexamethasone (EloRd) enhanced the clinical benefit over Rd with a manageable toxicity profile in the ELOQUENT-2 trial, leading to its approval in relapsed/refractory multiple myeloma (RRMM). The present study is a 3-year follow-up update of a previously published Italian real-life RRMM cohort of patients treated with EloRd. This revised analysis entered 319 RRMM patients accrued in 41 Italian centers. After a median follow-up of 36 months (range 6–55), 236 patients experienced disease progression or died. Median progression-free survival (PFS) and overall survival (OS) were 18.4 and 34 months, respectively. The updated multivariate analyses showed a significant reduction of PFS and OS benefit magnitude only in cases with International Staging System stage III. Major adverse events included grade 3/4 neutropenia (18.5%), anemia (15.4%), lymphocytopenia (12.5%), and thrombocytopenia (10.7%), while infection rates and pneumonia were 33.9% and 18.9%, respectively. No new safety signals with longer follow-up have been observed. Of 319 patients, 245 (76.7%) reached at least a partial remission. A significantly lower response rate was found in patients previously exposed to lenalidomide. In conclusion, our study confirms that EloRd is a safe and effective regimen for RRMM patients, maintaining benefits across multiple unfavorable subgroups