Quadratic detector response curve fit to data using space between the peaks of QC spectra.

<p>Quadratic detector response curve fit to data using space between the peaks of QC spectra.</p

CIN0 vs. CIN3 group tests (Mann-Whitney) based on peak height measurements under stringent condition (S/N 5/3) using Ciphergen Express.

<p>Showing only clusters with p-values less than 0.05.</p

An example peak cluster output from Ciphergen Express v3.5.

<p>An example peak cluster output from Ciphergen Express v3.5.</p

False-discovery rate and true-positive rate operating points showing various stages of improvement for LibSELDI.

<p>False-discovery rate and true-positive rate operating points showing various stages of improvement for LibSELDI.</p

CIN0 vs. CIN3 group tests (t-tests and Mann-Whitney U-tests) based on peak height and peak area measurements.

<p>Showing quantification (SEM) for clusters with p-values less than 0.05.</p

LibSELDI/neural network strategy for analyzing clinical spectra.

<p>LibSELDI/neural network strategy for analyzing clinical spectra.</p

Processing time (in seconds) for denoising a single spectrum using different implementations of the modified Antoniadis-Sapatinas algorithm.

<p>Processing time (in seconds) for denoising a single spectrum using different implementations of the modified Antoniadis-Sapatinas algorithm.</p

CIN0 vs. CIN3 prevalence differences scored using the Fisher-exact test with mid-P correction.

<p>Showing only clusters with p-values less than 0.05.</p

An example denoised peak using the FIR filter approach used for quantification.

<p>This is a typical example where the Antoniadis-Sapatinas denoising would find the peak but distort its peak height.</p

67^th order FIR filter frequency response designed for flat-pass band analogous to a Savitsky-Golay filter, but with better high-frequency noise suppression properties.

<p>67^th order FIR filter frequency response designed for flat-pass band analogous to a Savitsky-Golay filter, but with better high-frequency noise suppression properties.</p