54 research outputs found
An experimental study of the effect of the manipulation of the anxiety level through the use of sodium amytal on the learning of emotionally charged material
Thesis (Ed.D.)--Boston Universit
Case Report: Longitudinal follow-up and testicular sperm extraction in a patient with a pathogenic NR5A1 (SF-1) frameshift variant: p.(Phe70Serfs*5)
BackgroundSteroidogenic factor 1 (SF-1), encoded by the nuclear receptor subfamily 5 group A member 1 (NR5A1) gene, is a transcriptional factor crucial for adrenal and gonadal organogenesis. Pathogenic variants of NR5A1 are responsible for a wide spectrum of phenotypes with autosomal dominant inheritance including disorders of sex development and oligospermiaâazoospermia in 46,XY adults. Preservation of fertility remains challenging in these patients.ObjectiveThe aim was to offer fertility preservation at the end of puberty in an NR5A1 mutated patient.Case reportThe patient was born of non-consanguineous parents, with a disorder of sex development, a small genital bud, perineal hypospadias, and gonads in the left labioscrotal fold and the right inguinal region. Neither uterus nor vagina was detected. The karyotype was 46,XY. Anti-MĂŒllerian hormone (AMH) and testosterone levels were low, indicating testicular dysgenesis. The child was raised as a boy. At 9 years old, he presented with precocious puberty treated by triptorelin. At puberty, follicle-stimulating hormone (FSH), luteinising hormone (LH), and testosterone levels increased, whereas AMH, inhibin B, and testicular volume were low, suggesting an impaired Sertoli cell function and a partially preserved Leydig cell function. A genetic study performed at almost 15 years old identified the new frameshift variant NM_004959.5: c.207del p.(Phe70Serfs*5) at a heterozygous state. He was thus addressed for fertility preservation. No sperm cells could be retrieved from three semen collections between the ages of 16 years 4 months and 16 years 10 months. A conventional bilateral testicular biopsy and testicular sperm extraction were performed at 17 years 10 months of age, but no sperm cells were found. Histological analysis revealed an aspect of mosaicism with seminiferous tubules that were either atrophic, with Sertoli cells only, or presenting an arrest of spermatogenesis at the spermatocyte stage.ConclusionWe report a case with a new NR5A1 variant. The fertility preservation protocol proposed at the end of puberty did not allow any sperm retrieval for future parenthood
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Structure versus accident in the defeat of Franceâs mainstream Right, AprilâJune 2017
Widely expected to recapture Franceâs presidency and win a parliamentary major
ity in the 2017 elections, Franceâs mainstream Right instead suffered a crushing
and divisive defeat. A major reason for this was contingent: the selection of a candidate who three months before polling day was placed under investigation
for embezzling public funds. Other reasons were more structural, in particular
the progressive dislocation of the bipolar multipartism which had characterised
Franceâs party system for over four decades and the resultant strategic divisions
within the Right. Although broadly chronological, this analysis of the long electoral cycle of 2016â2017 assesses the respective importance of proximate and long-term factors in the Rightâs defeat
Les cinquante ans du Traité de Rome
50th anniversary of the Treaty of Rome
The 50th anniversary of the Treaty of Rome is an opportunity to retrace the steps taken by the promoters of European integration and pay tribute to the founding fathers. From the reform of Community institutions to the creation of a European monetary system, the author revisits the highlights of his political career and European commitment. Bearing witness to this commitment was his term as Chairman of the European Convention, which had the ambition of completing European integration and defining a long-term institutional framework for a united Europe.
JEL classification : F15, N14Le 50e anniversaire du TraitĂ© de Rome est lâoccasion de retracer le chemin parcouru par les promoteurs de la construction europĂ©enne et de rendre hommage aux pĂšres fondateurs. De la rĂ©forme des institutions communautaires Ă la crĂ©ation du systĂšme monĂ©taire europĂ©en, lâauteur revient sur ce qui a Ă©tĂ© au coeur de son action politique et de son engagement europĂ©en. En tĂ©moigne aussi sa prĂ©sidence de la Convention europĂ©enne dont lâambition fut celle de parachever la construction europĂ©enne et dâen dĂ©finir un cadre institutionnel pĂ©renne.
Classification JEL : F15, N14Giscard dâEstaing ValĂ©ry. Les cinquante ans du TraitĂ© de Rome . In: Revue d'Ă©conomie financiĂšre, n°88, 2007. 50 ans aprĂšs le TraitĂ© de Rome. pp. 19-24
Avant-propos
Giscard dâEstaing ValĂ©ry. Avant-propos. In: Le concile de Clermont de 1095 et lâappel Ă la croisade. Actes du Colloque Universitaire International de Clermont-Ferrand (23-25 juin 1995) Rome : Ăcole Française de Rome, 1997. pp. 9-14. (Publications de l'Ăcole française de Rome, 236
Valéry Giscard d'Estaing, Assemblée annuelle de la BIRD et du FMI, le 26 septembre 1971.
Giscard dâEstaing ValĂ©ry. ValĂ©ry Giscard d'Estaing, AssemblĂ©e annuelle de la BIRD et du FMI, le 26 septembre 1971. In: Revue d'Ă©conomie financiĂšre. Hors-sĂ©rie, 1994. Bretton Woods : mĂ©langes pour un cinquantenaire. p. 370
Préface
Il mâest trĂšs agrĂ©able dâaccompagner par quelques mots de prĂ©sentation les souvenirs de Guy Delorme. En raison tout dâabord de la personnalitĂ© de lâauteur. CompĂ©tent, prĂ©cis, ferme, droit, courageux, tels sont les mots qui viennent naturellement sous la plume pour parler de lui. Serviteur de lâĂtat, avec tout ce que cette expression peut avoir aujourdâhui, je mâen rends compte, de surannĂ©. Il apparaissait Ă notre gĂ©nĂ©ration que servir la collectivitĂ© dans un pays dĂ©vastĂ© et humiliĂ© par la gue..
Avant-propos
Giscard dâEstaing ValĂ©ry. Avant-propos. In: Le concile de Clermont de 1095 et lâappel Ă la croisade. Actes du Colloque Universitaire International de Clermont-Ferrand (23-25 juin 1995) Rome : Ăcole Française de Rome, 1997. pp. 9-14. (Publications de l'Ăcole française de Rome, 236
Valéry Giscard d'Estaing, Assemblée annuelle de la BIRD et du FMI, le 26 septembre 1971.
Giscard dâEstaing ValĂ©ry. ValĂ©ry Giscard d'Estaing, AssemblĂ©e annuelle de la BIRD et du FMI, le 26 septembre 1971. In: Revue d'Ă©conomie financiĂšre. Hors-sĂ©rie, 1994. Bretton Woods : mĂ©langes pour un cinquantenaire. p. 370
Préface
Il mâest trĂšs agrĂ©able dâaccompagner par quelques mots de prĂ©sentation les souvenirs de Guy Delorme. En raison tout dâabord de la personnalitĂ© de lâauteur. CompĂ©tent, prĂ©cis, ferme, droit, courageux, tels sont les mots qui viennent naturellement sous la plume pour parler de lui. Serviteur de lâĂtat, avec tout ce que cette expression peut avoir aujourdâhui, je mâen rends compte, de surannĂ©. Il apparaissait Ă notre gĂ©nĂ©ration que servir la collectivitĂ© dans un pays dĂ©vastĂ© et humiliĂ© par la gue..
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