PROSPECTIVE STUDY TO COMPARE INSULIN AND INSULIN ANALOGS IN TYPE II DIABETIC PATIENTS

Objective: To compare the safety and quality of life of insulin and insulin analogues in Type II Diabetic patients.Methods: 100 patients who are diagnosed with type – II diabetes milletus are taken.In these 50 patients are of insulin analogues and 50 patients are of conventional insulin The safety was based on number of hypoglycemic events.Data was collected by using the EQ-5D questionnaire and EQ Visual Analogue scale (EQ-VAS) to assess the quality of life from the patient.Result:The percentage of the patients who had hypoglycemic events in conventional insulin group is 54% (n=27) and insulin analogues group is 20% (n=10). Mean score points of QOL obtained by conventional insulin patients is 75.9 and by insulin analogues patients is 93.75Conclusion: Insulin analogues group has low risk of hypoglycaemia when compared with the conventional insulin.The patient group who are in No problem category are found to have better QOL. The safety and QOL statistical differences constitute less likely among insulin and insulin analogues. The use of insulin analogues will continue to advance our efforts at improving diabetes care and treated related adverse outcomes can be reduced

Inflammatory Myofibroblastic Pseudotumor of Ileum: A Rare Diagnosis

Inflammatory myofibroblastic pseudotumours are uncommon lesions of unknown etiology. Diverse nomenclature such as inflammatory pseudotumour, plasma cell granuloma, inflammatory myofibroblastoma and inflammatory myofibrohistioblastic proliferation have been used for this entity due to uncertainity regarding true biologic nature of these lesions. This tumour is composed of spindle cells with myofibroblastic proliferation accompanied by an inflammatory infiltrate of plasma cells. Since it was first described in 1937, the understanding of inflammatory myofibroblastic pseudotumour has evolved from a reactive inflammatory process to a neoplasm of intermediate biological potential. These are associated with nosologic, histogenetic and aetiopathogenetic controversy. They occur in all age groups and in diverse body sites, with equal propensity in males and females

Correlation between Modified Bloom Richardson Grade and Lymph Nodal Status in Infiltrating Ductal Type of Breast Carcinoma

Introduction: Breast cancer is one of the most common cancers in women. Among the various types, invasive ductal carcinomas (IDC), not otherwise specified (NOS) is the most common type. This study was conducted to describe the clinico-pathological parameters of breast cancer, and to find a correlation between two of the prognostic parameters, i.e., Bloom Richardson (BR) grade and lymph node metastasis. Materials and Methods: It was a cross-sectional study with a sample size of 100 cases. Routine clinical details and investigations of the patients were recorded, including age, TNM stage of tumour, etc. Further, the specimens were evaluated for the histological typing, histological grading, and status of lymph nodes. Also, statistical correlations were established between two of the prognostic parameters, i.e., BR grade and lymph node metastasis. Results: All the cases were NOS type of IDC. Majority of the cases belonged to pTNM stage III, followed by stage II. Maximum cases belonged to BR grade 2, followed by grade 3. Lymph node metastasis was present in 40% cases. A statistically significant correlation was seen between increasing BR grade and presence of lymph node metastasis in the tumour. Discussion and Conclusion: Majority of the cases in our study belong to high grade and stage. This is probably due to lack of awareness and late detection of breast carcinoma in Indian scenario. A statistically significant correlation was found between increasing BR grade and presence of lymph node metastasis in the tumour. Thus, these can be used along with other clinico-pathological parameters for prognostic and therapeutic planning in breast carcinoma cases

MHD Boundary Layer Flow and Heat Transfer to Sisko Nanofluid Past a Nonlinearly Stretching Sheet with Radiation

The steady flow of a Sisko fluid model in the presence of nanoparticles is studied. The governing partial differential equations are converted to a set of coupled non-linear ordinary differential equations by using suitable similarity transformations. Numerical solutions for the coupled non-linear ordinary differential equations are carried out by a variational finite element method. A suitable comparison has been made with previously published results in the literature as a limiting case of the considered problem. The comparison confirmed an excellent agreement. The results for the local Nusselt number are tabulated and discussed. Behavior of essential physical parameters are presented graphically and discussed for velocity, temperature and nanoparticle volume fraction

A functional RNase P protein subunit of bacterial origin in some eukaryotes

RNase P catalyzes 5′-maturation of tRNAs. While bacterial RNase P comprises an RNA catalyst and a protein cofactor, the eukaryotic (nuclear) variant contains an RNA and up to ten proteins, all unrelated to the bacterial protein. Unexpectedly, a nuclear-encoded bacterial RNase P protein (RPP) homolog is found in several prasinophyte algae including Ostreococcus tauri. We demonstrate that recombinant O. tauri RPP can functionally reconstitute with bacterial RNase P RNAs (RPRs) but not with O. tauri organellar RPRs, despite the latter’s presumed bacterial origins. We also show that O. tauri PRORP, a homolog of Arabidopsis PRORP-1, displays tRNA 5′-processing activity in vitro. We discuss the implications of the striking diversity of RNase P in O. tauri, the smallest known free-living eukaryote.Ministerio de Ciencia e Innovación European Regional Fund BFU2007-60651Junta de Andalucía P06-CVI-01692National Science Foundation MCB-0238233 MCB-0843543European Union ASSEMBLE 22779

Viscous Dusty Fluid Flow with Constant Velocity Magnitude

We consider the viscous dusty fluid, where the velocity of the dust particle is everywhere parallel to that of the fluid with velocity magnitude of the fluid is constant along each individual streamline. Also it is assumed that number density of the dust particle is constant and the dust particles are uniform in size and shape and bulk concentration of the dust is small. Hodograph and Legendre transform of stream function is employed to get the solutions and the geometry of streamlines for these flows by using the resulting partial differential equations when the Jacobian is zero and nonzero cases. In each case the variation of pressure is analyzed graphicall

Nonlinear Radiative Heat Transfer of Cu-Water Nanoparticles over an Unsteady Rotating Flow under the Influence of Particle Shape

A 3D study on Cu-water-rotating nanofluid over a permeable surface in the presence of nonlinear radiation is presented. Particle shape and thermophysical properties are considered in this study. The governing equations in partial forms are reduced to a system of nonlinear ordinary differential equations using suitable similarity transformations. An effective Runge-Kutta-Fehlberg fourth-fifth order method along with shooting technique is applied to attain the solution. The effects of flow parameters on the flow field and heat transfer characteristics were obtained and are tabulated. Useful discussions were carried out with the help of plotted graphs and tables. It is found that the rate of heat transfer is more enhanced in column-shaped nanoparticles when compared to tetrahedron- and sphere-shaped nanoparticles. Higher values of rotating parameter enhance the velocity profile and corresponding boundary layer thickness. It has quite the opposite behavior in angular velocity profile. Further, unsteady parameter increases the velocity profile and corresponding boundary layer thickness

Primary pure non-gestational choriocarcinoma of ovary: a rare case report

Germ cell malignancies represent 15% of ovarian cancers. Choriocarcinoma is a malignant tumour with trophoblastic differentiation. It may be gestational or non-gestational and may be a primary tumour or metastatic from other organs. Pure non-gestational choriocarcinoma is an extremely rare neoplasm, with reports of only a few cases. This study reports a rare case of non-gestational pure choriocarcinoma in a postmenarcheal young female and describes details of the tumour, including the clinicopathological findings. A young female presented with sudden onset anxiety, abdominal distention, severe abdominal pain, and severe pallor. Clinically, she was diagnosed as a case of ruptured ectopic pregnancy, and was taken up for emergency laparotomy. A right ovarian mass of 5X7 cm was seen, which was ruptured and was bleeding profusely. Right salpingo-oophorectomy was done, and it was diagnosed histopathologically as primary pure non-gestational choriocarcinoma of ovary. This case report describes the histopathological and immunohistochemical findings of this rare entity, as well as the various methods to differentiate between cases of non-gestational and gestational choriocarcinoma of the ovary. This is important as non-gestational choriocarcinoma has a poorer prognosis in comparison with gestational. Also, the treatment regimen for the two differs

Thermal Conductivity in the Boundary Layer of Non-Newtonian Fluid with Particle Suspension

The present chapter is focused on studies concerned with three-dimensional flow and heat transfer analysis of Carreau fluid with nanoparticle suspension. The heat transfer analysis in the boundary was carried out with the fluid flow over a stretching surface under the influence of nonlinear thermal radiation, mixed convection and convective boundary condition. Suitable similarity transformations are employed to reduce the governing partial differential equations into coupled nonlinear ordinary differential equations. The equations in non-linear form are then solved numerically using Runge-Kutta-Fehlberg fourth fifth-order method with the help of symbolic algebraic software MAPLE. The results so extracted are well tabulated and adequate discussions on the parameters affecting flow and heat transfer analysis were carried out with the help of plotted graphs

Pancreatic Cancer as a Landmark in Humans

ABSTRACT Cancer diseases still a troublesome human diseases and area unit robust to cure with restricted knowledge concerning the mechanisms of their development. Pancreatic ductal glandular cancer (PDAC) is one amongst the foremost common malignant tumors still associated with poor prognosis in advanced stages. This text may be a reference of the areas of cancer wherever this day work is concentrated on and this array of deep study cans sure as shooting leads to several facilitating changes within the treatment of cancer. Cancer diseases still a troublesome human diseases and area unit robust to cure with restricted knowledge concerning the mechanisms of their development. The studies have incontestable associate inflated prevalence of malignant neoplastic disease among female subpopulations of the tending trade, beside radiologists, radiology technicians, and orthopaedic surgeons. The association between cancer and radiation exposure is well established, and additionally the female breast is very in danger of the cancer-causing effects of radiation Patients with chronic inflammation (CP) might have shown resembling carcinoma (PaC) and also are risky for developing PAC, patitients with this normally gift with abdominal pain, symptom, weight loss or preventive jaundice that gibe those of carcinoma (PaC) from ductal glandular cancer and cause diagnostic confusion Pancreatic ductal glandular cancer (PDAC) is one amongst the foremost common malignant tumors still associated with poor prognosis in advanced stages. Gemcitabine is one amongst the quality agents for the treatment of PDAC Nuclear issue Of Activated T cells (NFAT) transcription factors promote exocrine gland carcinogenesis via distinct transcriptional programs resulting in augmented proliferation and growth, inhibition of crucial fail-safe mechanisms and interference with key tumor-suppressor functions "Microsatellites" area unit presently one among the foremost used genetic markers (outlined as loci) where short sequences of desoxyribonucleic acid square measure perennial in bike arrays. Their high length polymorphism and abundance altogether genomes build them the sequence of choice for a numerous vary of applications spanning linkage analysis and genetic mapping through to rhetorical and ecological and process studies Squamous cell cancer of the head and neck (HNSCC) is an evolving space of clinical and analysis focus with a rising prevalence of the illness within the females. Some human papillomavirus (HPV) varieties act as carcinogens that contribute to the event of HNSCC. Head and neck cancers of the cavity (hereafter abbreviated as HNSCC) generally originate inside the damp epithelial cell linings of the bodily cavity, lips, rima, secretion glands, tongue, taste bud, pharyx, and cartilaginous structur