32 research outputs found
Regulation of Hemolysin Expression and Virulence of Staphylococcus aureus by a Serine/Threonine Kinase and Phosphatase
- Author
- A Hayashida
- A Iliuk
- A Jeng
- A Sabat
- A Silvestroni
- AC Manna
- AG Cheng
- AH Bartlett
- AH Patel
- AJ Wolfe
- AM Beltramini
- Annalisa Lembo
- Anthony R. Richardson
- Anton Iliuk
- AR Richardson
- AR Richardson
- AT Giraudo
- AT Giraudo
- AT Giraudo
- AT Glenny
- AW Bernheimer
- B Fournier
- B Kreikemeyer
- B Said-Salim
- BD Corbin
- BE Ragle
- BM Benton
- Byron Z. Schmidt
- CL Peterson
- CS Kim
- D Schafer
- D Styers
- DO Chaffin
- DO Chaffin
- E Josefsson
- EB Hume
- F Vandenesch
- FD Lowy
- Ferric C. Fang
- FM Ausubel
- FR DeLeo
- FR DeLeo
- G Buist
- GM Wiseman
- H Cerutti
- HF Chambers
- HL Peng
- IM Nilsson
- J Begun
- J Bubeck Wardenburg
- J Bubeck Wardenburg
- J Bubeck Wardenburg
- J Kim
- J Oberto
- J Yao
- James E. Connelly
- JH Freer
- JM Mei
- JM Yarwood
- K Seidl
- K Traber
- KA Schmidt
- Kellie Burnside
- L O'Brien
- L Rajagopal
- L Rajagopal
- L Rajagopal
- Lakshmi Rajagopal
- M Bhakoo
- M Debarbouille
- M Huseby
- M Husmann
- M Otto
- MC Callegan
- Melissa de los Reyes
- MJ Sibbald
- MM Dinges
- N Okada
- Nguyen-Thao BinhTran
- P Hruz
- PJ McNamara
- PJ McNamara
- R Berner
- R Raggiaschi
- Ramy K. Aziz
- RG Krishna
- RJ O'Callaghan
- RJ Rubin
- RM Horton
- RP Adhikari
- RP Novick
- RP Novick
- RP Novick
- S Bhakdi
- S Bhakdi
- S Donat
- S Herbert
- SJ Projan
- T Baba
- T Bae
- T Kielian
- T Onogawa
- TD Schmittgen
- WA Altemeier
- Wan-Jung Lin
- Weiguo Andy Tao
- WJ Lin
- Y Dragneva
- YK Stranger-Jones
- Publication venue
- Public Library of Science
- Publication date
- 01/06/2010
- Field of study
Exotoxins, including the hemolysins known as the alpha (α) and beta (β) toxins, play an important role in the pathogenesis of Staphylococcus aureus infections. A random transposon library was screened for S. aureus mutants exhibiting altered hemolysin expression compared to wild type. Transposon insertions in 72 genes resulting in increased or decreased hemolysin expression were identified. Mutations inactivating a putative cyclic di-GMP synthetase and a serine/threonine phosphatase (Stp1) were found to reduce hemolysin expression, and mutations in genes encoding a two component regulator PhoR, LysR family transcriptional regulator, purine biosynthetic enzymes and a serine/threonine kinase (Stk1) increased expression. Transcription of the hla gene encoding α toxin was decreased in a Δstp1 mutant strain and increased in a Δstk1 strain. Microarray analysis of a Δstk1 mutant revealed increased transcription of additional exotoxins. A Δstp1 strain is severely attenuated for virulence in mice and elicits less inflammation and IL-6 production than the Δstk1 strain. In vivo phosphopeptide enrichment and mass spectrometric analysis revealed that threonine phosphorylated peptides corresponding to Stk1, DNA binding histone like protein (HU), serine-aspartate rich fibrinogen/bone sialoprotein binding protein (SdrE) and a hypothetical protein (NWMN_1123) were present in the wild type and not in the Δstk1 mutant. Collectively, these studies suggest that Stk1 mediated phosphorylation of HU, SrdE and NWMN_1123 affects S. aureus gene expression and virulence
Genome-Wide Patterns of Gene Expression during Aging in the African Malaria Vector Anopheles gambiae
- Author
- A Dana
- A Hill
- A-J Kim
- AM Ahmed
- Anthony A. James
- B Knols
- B Li
- BA Okech
- C Gourlay
- C Gruenewald
- C Lanciani
- C-Q Lai
- D Martin
- E Martinez-Lara
- Edward Walker
- F Norry
- FM Okanda
- G Landis
- G MacDonald
- G Macdonald
- Guiyun Yan
- H Kang
- HR Jensen
- J Semeiks
- J Yang
- JB Silver
- JJ McElwee
- JMC Ribeiro
- John Githure
- Jörg Hoheisel
- L Seroude
- LE Hugo
- LE Hugo
- M Arbeitman
- M Feder
- M Giraudo
- M Morey
- Mei-Hui Wang
- MH Hodjati
- ML Desena
- ML Desena
- N Minakawa
- Osvaldo Marinotti
- PE Cook
- R Bell
- R Sohal
- RP Thomas
- S Agarwal
- S Chen
- S Libert
- S Luckhart
- S McCarroll
- S Pletcher
- S Zou
- SD Pletcher
- SM Gorski
- T Brummel
- T Golden
- T Golden
- T Hastie
- TS Detinova
- V Mayagaya
- VP Polovodova
- WHO
- X Nirmala
- Y Liu
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2010
- Field of study
The primary means of reducing malaria transmission is through reduction in longevity in days of the adult female stage of the Anopheles vector. However, assessing chronological age is limited to crude physiologic methods which categorize the females binomially as either very young (nulliparous) or not very young (parous). Yet the epidemiologically relevant reduction in life span falls within the latter category. Age-grading methods that delineate chronological age, using accurate molecular surrogates based upon gene expression profiles, will allow quantification of the longevity-reducing effects of vector control tools aimed at the adult, female mosquito. In this study, microarray analyses of gene expression profiles in the African malaria vector Anopheles gambiae were conducted during natural senescence of females in laboratory conditions. Results showed that detoxification-related and stress-responsive genes were up-regulated as mosquitoes aged. A total of 276 transcripts had age-dependent expression, independently of blood feeding and egg laying events. Expression of 112 (40.6%) of these transcripts increased or decreased monotonically with increasing chronologic age. Seven candidate genes for practical age assessment were tested by quantitative gene amplification in the An. gambiae G3 strain in a laboratory experiment and the Mbita strain in field enclosures set up in western Kenya under conditions closely resembling natural ones. Results were similar between experiments, indicating that senescence is marked by changes in gene expression and that chronological age can be gauged accurately and repeatedly with this method. These results indicate that the method may be suitable for accurate gauging of the age in days of field-caught, female An. gambiae
Goodbye Hartmann trial: a prospective, international, multicenter, observational study on the current use of a surgical procedure developed a century ago
- Author
- Abate Emmanuele
- Abbassi Imed
- Abdoun Ahmed K.
- Abdullaev Abakar
- Abu-Zidan Fikri
- Acheimastos Vasileios
- Agackiran Ibrahim
- Agnoletti Vanni
- Agrusa Antonino
- Agundez María Carmona
- Agus Marcello
- Aizza Giada
- Akin Emrah
- Alconchel Felipe
- Alegre Javier Martínez
- Alemanno Giovanni
- Ali Ali Ben
- Almeida Filipe
- Altinel Yuksel
- Altıntaş Yasemin
- Altintoprak Fatih
- Ambrosi Antonio
- Ammar Houssem
- Anania Gabriele
- Andreuccetti Jacopo
- Andrés María Inmaculada Pérez
- Anestiadou Elissavet
- Ansaloni Luca
- Antona Francisco Blanco
- Aparicio-Sánchez Daniel
- Aprea Giovanni
- Aranaz-Ostariz Veronica
- Aranda-Narváez Jose Manuel
- Ardito Antonella
- Argenio Giulio
- Armellino Mariano Fortunato
- Armento Isabella
- Asti Emanuele Luigi Giuseppe
- Atanasov Boyko
- Atici Semra Demirli
- Augustin Goran
- Aurélien Venara
- Austin Tyler R.
- Avgerinos Konstantinos
- Ayed Karim
- Azzinnaro Antonio
- Bagolini Francesco
- Baili Efstratia
- Bains Lovenish
- Baiocchi Gian Luca
- Bajul Melinda
- Bala Miklosh
- Balık Emre
- Balla Andrea
- Banchini Filippo
- Bañolas-Suarez Raquel
- Baraket Oussama
- Barberis Andrea
- Bardes James M.
- Bayhan Zulfu
- Bayrak Mehmet
- Belev Nikolay
- Belvedere Angela
- Benzoni Ilaria
- Bernardi Daniele Tiziano
- Berti Stefano
- Bertino Vanessa
- Bertoli Paolo
- Bianchi Valentina
- Biffl Walter L.
- Biloslavo Alan
- Boati Paolo
- Bogdanić Branko
- Bolzon Stefano
- Bombardini Cristina
- Bonati Elena
- Bonilauri Stefano
- Bonomi Alessandro
- Borghi Felice
- Bosch-Ramírez Marina
- Bougard Marie
- Bouliaris Konstantinos
- Boura Maria
- Bourbouteli Eirini
- Bozkurt Mehmet Abdussamet
- Brachini Gioia
- Bradley Alison
- Bravi Francesca
- Bravo Altea Arango
- Buffone Angelica
- Buonfantino Massimo
- Buscemi Salvatore
- Caamaño Aloia Guerreiro
- Cadeo Alessandro
- Cairl Nicholas
- Calu Valentin
- Campa Rossella Domenica
- Campana Juan P.
- Campos-Serra Andrea
- Cannavera Alessandro
- Canton Cassio Alfred Brattig
- Capelli Patrizio
- Capolupo Gabriella Teresa
- Capponi Michela Giulii
- Capuano Marianna
- Carannante Filippo
- Cardamone Eugenia
- Cardoso Paulo Sebastião
- Caricato Marco
- Carmona Zahira Gómez
- Carneiro Carla
- Carvas João
- Casadei Massimiliano
- Casati Massimiliano
- Casiraghi Silvia
- Casole Giovanni
- Castaldo Pasquale
- Catena Fausto
- Cattaneo Gaetano Maria
- Cavallo Fabio
- Cellerino Paola
- Cereda Marco
- Ceresoli Marco
- Chahrour Ali Chaouki
- Chamzin Alexandros
- Charalabopoulos Alexandros
- Chierici Andrea
- Chouillard Elie
- Chrysos Emmanuel
- Cianci Pasquale
- Cicconi Simone
- Cillara Nicola
- Clarizia Guglielmo
- Clerici Federico
- Cloquell Miriam Moratal
- Coccolini Federico
- Coffua Lauren S.
- Coimbra Raul
- Colak Elif
- Conti Luigi
- Corbellini Carlo
- Cordeiro-Fonseca Vinicius
- Cotsoglou Christian
- Cruz Daniel Rios
- Cuellar Jose Aurelio Navas
- Cumplido Paola Lora
- Curtiss William
- Czyżykowski Łukasz
- da Costa Silvia Dantas
- Das Koray
- Dawoud Christopher
- de León Laura Román García
- de los Ángeles Gil Olarte-Marquez Ma
- De Luca Maurizio
- de Manzoni Garberini Andrea
- de Mendonça Nuno Gonçalo Gonçalves
- de Mesquita Tauil Renato
- De Palma Giovanni Domenico
- de Quiros Javier Tomas Morales Bernaldo
- De Sario Giuseppina
- De Simone Belinda
- Degiuli Maurizio
- Del Monte Simone Rossi
- del Pozo Eduardo Perea
- Delgado Edward
- Delvecchio Antonella
- Demetrashvili Zaza
- Demirbas Eren
- Depalma Norma
- Di Buono Giuseppe
- Di Salvo Maria
- Dimov Stefan
- Dimova Ana
- Dinuzzi Vincenza Paola
- Díez-Alonso Manuel
- Domínguez Carlota López
- Dorken Ander
- Dos Barbeito Sandra
- Doudakmanis Christos
- Du Bois María Esther
- Dziakova Jana
- D’Acapito Fabrizio
- D’Alessio Rossella
- D’Ugo Stefano
- Echeverria-Rosario Karla
- Edwards Sara
- Egodage Tanya
- Elizalde Aurea Barbara Rodriguez
- Ercolani Giorgio
- Esposito Francesco
- Esposito Giuseppe
- Esposito Marialusia
- Estaire-Gómez Mercedes
- Fabbri Anna
- Fabbri Nicolò
- Farré Silvia Pérez
- Favi Francesco
- Felsenreich Daniel M.
- Feo Carlo V.
- Fernandes Urânia
- Fernández Rocio Torres
- Ferrara Francesco
- Ferrari Davide
- Ferreira Ana Rita Oliveira
- Ferreira Cátia
- Filippelli Alice
- Firat Necattin
- Fleres Francesco
- Florence Charlotte
- Fnaiech Iskander
- Fogato Luisella
- Fontana Michele
- Fradelos Evangelos
- Fraga Gustavo P.
- Fransvea Pietro
- Frontali Alice
- Frountzas Maximos
- Fumagalli Chiara
- Gachabayov Mahir
- Gambino Giovanni
- García Juan Jesús Rubio
- Garulli Gianluca
- Gasser Elisabeth
- Gattulli Domenico
- Gebran Anthony
- Germani Paola
- Gil-Martínez José
- Gioco Rossella
- Giraudo Giorgio
- Giuffrida Mario
- Gomes Carlos Augusto
- Gomes Felipe Couto
- Gomez Maite Santamaria
- Gonullu Emre
- Gonzaga Ricardo Alessandro Teixeira
- González-Castillo Ana María
- Goulart André
- Grassi Carmine
- Gràcia-Roman Raquel
- Guaitoli Eleonora
- Guercioni Gianluca
- Guerra Enrico
- Guerra Martina
- Guner Ali
- Gupta Rahul
- Hacım Nadir Adnan
- Hamid Hytham K. S.
- Hemmila Mark
- Hentati Hassen
- Hernandez Edgard Efren Lozada
- Hinojosa-Ugarte Diego
- Huguet Jose Mugüerza
- Hyman Theodore S.
- Iglesias Eva
- Ilhan Onur
- Inama Marco
- Ioannidis Orestis
- Isernia Roberta Maria
- Isik Arda
- Jakubauskas Matas
- Jalal-Eldin Sami
- Jimenez-Riera Granada
- Jimenez-Vega Javier
- Jiménez Beatriz Muñoz
- Jovine Elio
- Jusoh Asri Che
- Kafka-Ritsch Reinhold
- Kara Yasin
- Karavokyros Ioannis
- Katunin Jevgeni
- Kavalieratos George
- Kaya Tayfun
- Kchaou Ali
- Kechagias Aristotelis
- Kedar Asaf
- Khalil Hany
- Khan Mansoor
- Khanduri Archana
- Kimpizi Despina
- Kobe Yoshiro
- Kocataş Ali
- Kokkinakis Stamatios
- Korkolis Dimitrios
- Koukoulis Georgios
- Kovachev Nikola
- Koylu Zehra Alan
- Kruger Vitor F.
- Kryzauskas Marius
- Kuzeridis Harilaos
- Kwiatkowski Andrzej
- Lacko Vladimír
- Laforgia Rita
- Lantone Giuliano
- Lantone Giulio
- Lapolla Pierfrancesco
- Latifi Rifat
- Latorraca José
- Lauka Lelde
- Látečková Zuzana
- Leao Pedro
- Lecchi Francesca
- Leo Cosimo Alex
- Lepiane Pasquale
- Lepre Luca
- Lesko Dusan
- Letizia Laface
- Liasis Lampros
- Litvin Andrey
- Livrini Marco
- Lohsiriwat Varut
- Lombardi Raffaele
- Lopez Ana
- Lorusso Leonardo
- Lostoridis Eftychios
- Loutzidou Lydia
- Lovisetto Federico
- Lozano Rafael Calleja
- López Joaquín Ruiz
- López-Sánchez Jaime
- Luppi Davide
- Luzzi Andrea-Pierre
- Magnone Stefano
- Major Piotr
- Manatakis Dimitrios K.
- Manca Giuseppe
- Manigrasso Michele
- Manso Maria Isabel Cerqueira
- Mantoglu Baris
- Manunza Romina
- Margaris Ioannis
- Maria Sotiropoulou
- Marinis Athanasios
- Marino Fabio
- Maroulis Ioannis
- Marques Rita
- Martines Gennaro
- Martínez Manuel Durán
- Martínez-López Elías
- Martínez-Pérez Aleix
- Massucco Paolo
- Mazzini Federico N.
- McClure Amanda
- Meléndez L. Juan José
- Membrilla-Fernández Estela
- Memis Ufuk
- Mendoza-Moreno Fernando
- Mentz Ricardo
- Merabishvili Giorgi
- Meric Serhat
- Michalopoulos Nikolaos
- Micó Silvia Sevila
- Milone Marco
- Mingoli Andrea
- Miron Adrian
- Mitei Mercy
- Moller Elsa García
- Mongkhonsupphawan Aitsariya
- Monroy Jose maria Victor Palomo
- Monsellato Igor
- Morais Henrique Manuel Cardoso
- Morales-Sevillano Xavier
- Moreira Claudia Cristina Lopes
- Moreno Cristina Ruiz
- Moreno Verónica Polaino
- Moretto Gianluigi
- Morić Trpimir
- Mulita Francesk
- Muñoz-Campaña Anna
- Musa Nicola
- Nagliati Carlo
- Nagorni Eleni-Aikaterini
- Napolitano Lena M.
- Nechay Taras
- Nicolás-López Tatiana
- Nisa Francisca García-Moreno
- Nita Gabriela Elisa
- Notarnicola Margherita
- Oliva Alba
- Olmi Stefano
- Omarov Nail
- Oragano Luigi
- Orio Gianluca
- Osella Giulia
- Oury Jeffrey
- Ozer Nazmi
- Ozkan Zeynep
- O’Sullivan Sara Nuñez
- Palini Gian Marco
- Palisi Marco
- Palmer Amanda
- Palmieri Francesco
- Palomba Giuseppe
- Panebianco Annunziata
- Panis Yves
- Pantalone Desire
- Panyko Arpád
- Papacostantinou Ioannis
- Papagni Vincenzo
- Papis Davide
- Pardo Pablo Sancho
- Parini Dario
- Parker Robert
- Patrocínio Sara Daniela Direito
- Pattacini Gianmaria Casoni
- Pauzas Henrikas
- Pavone Giovanna
- Pellino Gianluca
- Pelloni María
- Pereira Bela
- Pereira Bruno Monteiro
- Pereira Rita Gonçalves
- Perez Aintzane Lizarazu
- Perez Diego Pita
- Perrone Fabrizio
- Perrone Gennaro
- Pesce Antonio
- Petit Nuria Mestres
- Petracca Gabriele Luciano
- Petrakis Georgios
- Petropoulou Thalia
- Petruzzelli Luca
- Pezzoli Isabella
- Pezzolla Angela
- Pędziwiatr Michał
- Picardi Biagio
- Picariello Erika
- Picciariello Arcangelo
- Piccoli Micaela
- Picheo Roberto
- Pighin Marina
- Pignata Giusto
- Pinto Francisca Lima
- Pipia Irakli
- Pisano Marcello
- Pisano Michele
- Pisanu Adolfo
- Pisarska-Adamczyk Magdalena
- Podda Mauro
- Polat Suleyman
- Polenta Eleni
- Polydorou Andreas
- Ponce Iñigo Augusto
- Pontarolo Nicholas
- Pontillo Marcelo
- Portale Giuseppe
- Poskus Tomas
- Prando Daniela
- Pujante Antonio
- Quick Jacob A.
- Quiodettis Martha
- Radonak Jozef
- Rahy-Martin Aida Cristina
- Rampini Alessia
- Rana Mridul
- Ranieri Valerio
- Ranketi Sinkeet
- Ratnasekera Asanthi
- Reames Summer
- Reddavid Rossella
- Reis Murat Emre
- Restini Enrico
- Reynaud Alejandro Bañon
- Ricci Claudio
- Riss Stefan
- Rivera-Alonso Daniel
- Rocha Catarina
- Rocha Ricardo
- Rodas María Elisa Valle
- Romacho-López Laura
- Ronconi Maurizio
- Roscio Francesco
- Rossi Giorgio
- Rossi Stefano
- Rottoli Matteo
- Roulet Maxime
- Ruiz Enrique Colás
- Russo Iris Shari
- Salazar Yeniffer Tatiana Moreno
- Salvans Silvia
- Sampietro Gianluca Matteo
- Sangji Naveen F.
- Sarnari Jlenia
- Sarro Giuliano
- Sartelli Massimo
- Sasia Diego
- Sánchez-Guillén Luis
- Scandroglio Ildo
- Scaramuzzo Rosa
- Schaffer Kathryn
- Scheiterle Maximilian
- Schifano Domenico
- Schizas Dimitrios
- Sebastián-Tomás Juan Carlos
- Seker Ahmet
- Sena Giuseppe
- Seng Sirivan Suon
- Serradilla-Martín Mario
- Sganga Gabriele
- Shimamura Fumihiko
- Siannis Ioannis
- Sierra Isabel Blesa
- Simó Ignacio Rey
- Singh Sudhir K.
- Sofia Silvia
- Solaini Leonardo
- Soltes Marek
- Spampinato Marcello
- Spinelli Stefano
- Spolini Alessandro
- Spolverato Ylenia
- Stylianos Kapiris
- Svagzdys Saulius
- Swaminathan Christie
- Syllaios Athanasios
- Tanzanu Marta
- Tarasconi Antonio
- Tartaglia Nicola
- Tasis Nikolaos
- Tebala Giovanni D.
- Termes-Serra Roser
- Theodorou Dimitrios
- Tian Brian W. C. A.
- Titos-García Alberto
- Tlili Ahmed
- Toma Elena Adelina
- Toma Takayuki
- Tonucci Tommaso Panici
- Torre Beatrice
- Torres Álvaro Naranjo
- Totaro Luigi
- Toutouzas Konstantinos
- Triantafyllou Tania
- Trigiante Giuseppe
- Troian Marina
- Trostchansky Ivan
- Truong Hung P.
- Tsouknidas Ioannis
- Tuncer Korhan
- Turrado-Rodriguez Victor
- Tyagunov Alexander
- Uccelli Matteo
- Usta Mehmet Arif
- Uymaz Derya Salim
- Uzunoglu Mustafa Yener
- Vailas Michail
- Valcárcel Cristina Rey
- Valle Naila Pagès
- Vallicelli Carlo
- Vassiliu Panteleimon
- Velmahos George
- Veneroni Simone
- Veroux Gastone
- Veroux Massimiliano
- Vincenti Leonardo
- Visconti Diego
- Vitón-Herrero Rebeca
- Walędziak Maciej
- Watfah Josef
- Wilson Michael
- Wong Michael Pak-Kai
- Xenaki Sofia
- Yuldashev Anvar
- Zakaria Andee Dzulkarnaen
- Zakaria Muhammad Nazreen
- Zakaria Zaidi
- Zanzi Federico
- Zelić Zdravko
- Zem Leticia Gonçalves
- Zese Monica
- Zilinskas Justas
- Zonta Sandro
- Zribi Imen
- Zuin Matteo
- Publication venue
- Publication date
- 01/01/2024
- Field of study
Background: Literature suggests colonic resection and primary anastomosis (RPA) instead of Hartmann's procedure (HP) for the treatment of left-sided colonic emergencies. We aim to evaluate the surgical options globally used to treat patients with acute left-sided colonic emergencies and the factors that leading to the choice of treatment, comparing HP and RPA. Methods: This is a prospective, international, multicenter, observational study registered on ClinicalTrials.gov. A total 1215 patients with left-sided colonic emergencies who required surgery were included from 204 centers during the period of March 1, 2020, to May 31, 2020. with a 1-year follow-up. Results: 564 patients (43.1%) were females. The mean age was 65.9 ± 15.6 years. HP was performed in 697 (57.3%) patients and RPA in 384 (31.6%) cases. Complicated acute diverticulitis was the most common cause of left-sided colonic emergencies (40.2%), followed by colorectal malignancy (36.6%). Severe complications (Clavien-Dindo ≥ 3b) were higher in the HP group (P < 0.001). 30-day mortality was higher in HP patients (13.7%), especially in case of bowel perforation and diffused peritonitis. 1-year follow-up showed no differences on ostomy reversal rate between HP and RPA. (P = 0.127). A backward likelihood logistic regression model showed that RPA was preferred in younger patients, having low ASA score (≤ 3), in case of large bowel obstruction, absence of colonic ischemia, longer time from admission to surgery, operating early at the day working hours, by a surgeon who performed more than 50 colorectal resections. Conclusions: After 100 years since the first Hartmann's procedure, HP remains the most common treatment for left-sided colorectal emergencies. Treatment's choice depends on patient characteristics, the time of surgery and the experience of the surgeon. RPA should be considered as the gold standard for surgery, with HP being an exception
Effects of hospital facilities on patient outcomes after cancer surgery: an international, prospective, observational study
- Author
- A Yacoub M.
- A. Adam M.
- A. Nassar M.
- A. Nemer A.
- Aahlin E. K.
- Ab Rahim M. F.
- Abad Gurumeta A.
- Abad-Motos A.
- Abang Jamari D. Z. H.
- Abantanga F.
- Abarca S.
- Abazid E.
- Abbas A.
- Abbas K.
- Abbas M. M.
- Abbasy J.
- Abbosh A.
- Abd B.
- Abd Karim M. F. S.
- Abd Wahab H. H.
- Abdalei A.
- Abdalla Ahmed Elkamel A.
- Abdallah A.
- AbdAllah M. S. M.
- Abdel Malik A. B.
- Abdelhady Mousa H.
- Abdelhady S.
- Abdelhakim A.
- Abdelkader M.
- Abdelkawy S.
- Abdelkhalek M.
- Abdellatif E.
- Abdelmaksoud Tawakel N.
- Abdelmohsen N.
- Abdelmotaleb I.
- Abdelrazek A.
- Abdelsalam I.
- Abdelshakour M.
- Abdelwahed A. M.
- Abdou A.
- Abdou A. O.
- Abdou H.
- Abdul Aziz M. R.
- Abdul Aziz N.
- Abdulgawad Almogy M.
- Abdulla M. A.
- Abdullah M. T.
- Abdullahi L.
- Abdullayev S.
- Abed S.
- Abello D.
- Abiola O.
- Abo mahadi A.
- Abo-khammash A.
- Abou Chaar M. K.
- Abou El. soud M. R.
- Abouelsoad N.
- Abraham J.
- Abreu da Silva A.
- Abu Ahammala A. B.
- Abu Al Amrain M.
- Abu Al-saleem H.
- Abu Alamrain A.
- Abu Alqumboz A.
- Abu Ataya A.
- Abu hallalah M. F. K.
- Abu Jamie N.
- Abu Jayyab I.
- Abu shua'ib R.
- Abu Zainah B.
- Abu-Nimeh S.
- Abu-Rous M. R.
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- Zupan D.
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2022
- Field of study
Background Early death after cancer surgery is higher in low-income and middle-income countries (LMICs) compared with in high-income countries, yet the impact of facility characteristics on early postoperative outcomes is unknown. The aim of this study was to examine the association between hospital infrastructure, resource availability, and processes on early outcomes after cancer surgery worldwide.Methods A multimethods analysis was performed as part of the GlobalSurg 3 study-a multicentre, international, prospective cohort study of patients who had surgery for breast, colorectal, or gastric cancer. The primary outcomes were 30-day mortality and 30-day major complication rates. Potentially beneficial hospital facilities were identified by variable selection to select those associated with 30-day mortality. Adjusted outcomes were determined using generalised estimating equations to account for patient characteristics and country-income group, with population stratification by hospital.Findings Between April 1, 2018, and April 23, 2019, facility-level data were collected for 9685 patients across 238 hospitals in 66 countries (91 hospitals in 20 high-income countries; 57 hospitals in 19 upper-middle-income countries; and 90 hospitals in 27 low-income to lower-middle-income countries). The availability of five hospital facilities was inversely associated with mortality: ultrasound, CT scanner, critical care unit, opioid analgesia, and oncologist. After adjustment for case-mix and country income group, hospitals with three or fewer of these facilities (62 hospitals, 1294 patients) had higher mortality compared with those with four or five (adjusted odds ratio [OR] 3.85 [95% CI 2.58-5.75]; p<0.0001), with excess mortality predominantly explained by a limited capacity to rescue following the development of major complications (63.0% vs 82.7%; OR 0.35 [0.23-0.53]; p<0.0001). Across LMICs, improvements in hospital facilities would prevent one to three deaths for every 100 patients undergoing surgery for cancer.Interpretation Hospitals with higher levels of infrastructure and resources have better outcomes after cancer surgery, independent of country income. Without urgent strengthening of hospital infrastructure and resources, the reductions in cancer-associated mortality associated with improved access will not be realised
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- Author
- Abe Toshinori
- Abernathy Jason M.
- Abramowicz Halina
- Adamus Marek
- Adeva Bernardo
- Afanaciev Konstantin
- Aguilar-Saavedra Juan Antonio
- Alabau Pons Carmen
- Albrecht Hartwig
- Andricek Ladislav
- Anduze Marc
- Aplin Steve J.
- Arai Yasuo
- Asano Masaki
- Attie David
- Attree Derek J.
- Bailey David
- Balbuena Juan Pablo
- Ball Markus
- Ballin James
- Barbi Mauricio
- Barlow Roger
- Bartels Christoph
- Bartsch Valeria
- Bassignana Daniela
- Bates Richard
- Baudot Jerome
- Bechtle Philip
- Beck Jeannine
- Beckmann Moritz
- Bedjidian Marc
- Behnke Ties
- Belkadhi Khaled
- Bellerive Alain
- Bentvelsen Stan
- Bergauer Thomas
- Berggren C. Mikael U.
- Bergholz Matthias
- Bernreuther Werner
- Besancon Marc
- Besson Auguste
- Bhattacharya Sudeb
- Bhuyan Bipul
- Biebel Otmar
- Bilki Burak
- Blair Grahame
- Blumlein Johannes
- Bo Li
- Boer Wim
- Boisvert Veronique
- Bondar A.
- Bonvicini Giovanni
- Boos Eduard
- Boudry Vincent
- Bouquet Bernard
- Bouvier Joel
- Bozovic-Jelisavcic Ivanka
- Brient Jean-Claude
- Brock Ian
- Brogna Andrea
- Buchholz Peter
- Buesser Karsten
- Bulgheroni Antonio
- Burger Jochen
- Butler John
- Buttar Craig
- Buzulutskov A. F.
- Caccia Massimo
- Caiazza Stefano
- Calcaterra Alessandro
- Caldwell Allen
- Callier Stephane L. C.
- Calvo Alamillo Enrique
- Campbell Alan J.
- Campbell Michael
- Cappellini Chiara
- Carloganu Cristina
- Castro Carballo Maria Elena
- Castro Nuno
- Chadeeva Marina
- Chakraborty Dhiman
- Chang Paoti
- Charpy Alexandre
- Chen Hongfang
- Chen Shaomin
- Chen Xun
- Cheon Byunggu
- Choi Suyong
- Choudhary B. C.
- Christen Sandra
- Ciborowski Jacek
- Ciobanu Catalin
- Claus Gilles
- Clerc Catherine
- Coca Cornelia
- Colas Paul
- Colijn Auke
- Colledani Claude
- Combaret Christophe
- Cornat Remi
- Cornebise Patrick
- Corriveau Francois
- Cvach Jaroslav
- Czakon Michal
- D Ascenzo Nicola
- Da Silva Wilfrid
- Dadoun Olivier
- Dam Mogens
- Damerell Chris
- Danilov Mikhail
- Daniluk Witold
- Daubard Guillaume
- David Dorte
- David Jacques
- Decotigny David
- Dehmelt Klaus
- Delagnes Eric
- Deng Zhi
- Desch Klaus
- Dieguez Angel
- Diener Ralf
- Dima Mihai-Octavian
- Dissertori Gunther
- Dixit Madhu S.
- Dolezal Zdenek
- Dolgoshein Boris A.
- Dollan Ralph
- Doren Brian
- Dorokhov Andrei
- Doublet Philippe
- Doyle Tony
- Doziere Guy
- Dragicevic Marko
- Drasal Zbynek
- Drugakov Vladimir
- Duarte Campderros Jordi
- Dulucq Frederic
- Dumitru Laurentiu Alexandru
- Dzahini Daniel
- Eberl Helmut
- Eckerlin Guenter
- Ehrenfeld Wolfgang
- Eigen Gerald
- Eklund Lars
- Elsen Eckhard
- Elsener Konrad
- Emeliantchik Igor
- Engels Jan
- Evrard Christophe
- Fabbri Riccardo
- Faber Gerard
- Faucci Giannelli Michele
- Faus-Golfe Angeles
- Feege Nils
- Feng Cunfeng
- Ferencei Jozef
- Fernandez Garcia Marcos
- Filthaut Frank
- Fleck Ivor
- Fleischer Manfred
- Fleta Celeste
- Fleury Julien L.
- Fontaine Jean-Charles
- Foster Brian
- Fourches Nicolas
- Fouz Mary-Cruz
- Frank Sebastian
- Frey Ariane
- Frotin Mickael
- Fujii Hirofumi
- Fujii Keisuke
- Fujimoto Junpei
- Fujita Yowichi
- Fusayasu Takahiro
- Fuster Juan
- Gaddi Andrea
- Gaede Frank
- Galkin Alexei
- Galkin Valery
- Gallas Abraham
- Gallin-Martel Laurent
- Gamba Diego
- Gao Yuanning
- Garrido Beltran Lluis
- Garutti Erika
- Gastaldi Franck
- Gaur Bakul
- Gay Pascal
- Gellrich Andreas
- Genat Jean-Francois
- Gentile Simonetta
- Gerwig Hubert
- Gibbons Lawrence
- Ginina Elena
- Giraud Julien
- Giraudo Giuseppe
- Gladilin Leonid
- Goldstein Joel
- Gonzalez Sanchez Francisco Javier
- Gournaris Filimon
- Graaf Harry
- Greenshaw Tim
- Greenwood Z. D.
- Grefe Christian
- Gregor Ingrid-Maria
- Grenier Gerald Jean
- Gris Philippe
- Grondin Denis
- Groot Nicolo
- Grunewald Martin
- Grzelak Grzegorz
- Gurtu Atul
- Haas Tobias
- Haensel Stephan
- Hajdu Csaba
- Hallermann Lea
- Han Liang
- Hansen Peter H.
- Hara Takanori
- Harder Kristian
- Hartin Anthony
- Haruyama Tomiyoshi
- Harz Martin
- Hasegawa Yoji
- Hauschild Michael
- He Qing
- Hedberg Vincent
- Hedin David
- Heinze Isa
- Helebrant Christian
- Henschel Hans
- Hensel Carsten
- Hertenberger Ralf
- Herve Alain
- Higuchi Takeo
- Himmi Abdelkader
- Hironori Kazurayama
- Hlucha Hana
- Hommels Bart
- Horii Yasuyuki
- Horvath Dezso
- Hostachy Jean-Yves
- Hou Wei-Shu
- Hu-Guo Christine
- Huang Xingtao
- Huppert Jean Francois
- Ide Yasuhiro
- Idzik Marek
- Iglesias Escudero Carmen
- Ignatenko Alexandr
- Igonkina Olga
- Ikeda Hirokazu
- Ikematsu Katsumasa
- Ikemoto Yukiko
- Ikuno Toshinori
- Imbault Didier
- Imhof Andreas
- Imhoff Marc
- Ingbir Ronen
- Inoue Eiji
- Ioannis Giomataris
- Ishikawa Akimasa
- Itagaki Kennosuke
- Ito Kazutoshi
- Itoh Hideo
- Iwabuchi Masaya
- Iwai Go
- Iwamoto Toshiyuki
- Jacosalem Editha P.
- Jaramillo Echeverria Richard
- Jeans Daniel T. D.
- Jing Fanfan
- Jing Ge
- Jokic Stevan
- Jong Paul
- Jong Sijbrand
- Jonsson Leif
- Jore Matthieu
- Jovin Tatjana
- Kafer Daniela
- Kajino Fumiyoshi
- Kamai Yusuke
- Kaminski Jochen
- Kamiya Yoshio
- Kaplan Alexander
- Kapusta Frederic
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- Stockinger Dominik
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- Stromhagen Richard
- Sudo Yuji
- Suehara Taikan
- Suekane Fumihiko
- Suetsugu Yusuke
- Sugimoto Yasuhiro
- Sugiyama Akira
- Sumisawa Kazutaka
- Suzuki Shiro
- Swientek Krzysztof
- Tabassam Hajrah
- Takahashi Tohru
- Takeda Hiroshi
- Takeshita Tohru
- Takubo Yosuke
- Tanabe Tomohiko
- Tanaka Ken-Ichi
- Tanaka Manobu
- Tanaka Shuji
- Tapprogge Stefan
- Tarkovsky Evgueny I.
- Tauchi Kazuya
- Tauchi Toshiaki
- Telnov Valery I.
- Teodorescu Eliza
- Thomson Mark
- Tian Junping
- Timmermans Jan
- Titov Maxim P.
- Tokushuku Katsuo
- Tozuka Shunsuke
- Tsuboyama Toru
- Ueno Koji
- Ullan Miguel
- Uozumi Satoru
- Urakawa Junji
- Ushakov Andriy
- Ushiroda Yutaka
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- Verzocchi Marco
- Vescovi Christophe
- Videau Henri L.
- Vila Ivan
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- Vreeswijk Marcel
- Walsh Roberval
- Waltenberger Wolfgang
- Wang Meng
- Wang Michael
- Wang Min-Zu
- Wang Qun
- Wang Xiaoliang
- Wang Yi
- Ward David R.
- Warren Matthew
- Watanabe Minori
- Watanabe Takashi
- Watson Nigel K.
- Wattimena Nanda
- Wendt Oliver
- Wermes Norbert
- Weuste Lars
- Wichmann Katarzyna
- Wienemann Peter
- Wierba Wojciech
- Wilson Graham W.
- Wilson John A.
- Wing Matthew
- Winter Marc
- Wobisch Markus
- Worek Malgorzata
- Xella Stefania
- Xu Zizong
- Yamaguchi Akira
- Yamaguchi Hiroshi
- Yamamoto Hitoshi
- Yamaoka Hiroshi
- Yamashita Satoru
- Yamauchi M.
- Yamazaki Yuji
- Yamouni Mahfoud
- Yan Wenbiao
- Yanagida Koji
- Yang Haijun
- Yang Jin Min
- Yang Jongmann
- Yang Zhenwei
- Yasu Yoshiji
- Yonamine Ryo
- Yoshida Kohei
- Yoshida Takuo
- Yoshioka Tamaki
- Yu Chunxu
- Yu Intae
- Yue Qian
- Zacek Josef
- Zalesak Jaroslav
- Zarnecki Aleksander Filip
- Zawiejski Leszek
- Zeitnitz Christian
- Zerwas Dirk
- Zeuner Wolfram
- Zhang Renyou
- Zhang Xueyao
- Zhang Yanxi
- Zhang Zhiqing
- Zhang Ziping
- Zhao Jiawei
- Zhao Zhengguo
- Zheng Baojun
- Zhong Liang
- Zhou Yongzhao
- Zhu Chengguang
- Zhu Xianglei
- Zomer Fabian
- Zutshi Vishnu
- Publication venue
- Publication date
- 31/05/2010
- Field of study
无线传感器网络,作为全球未来十大技术之一,集成了传感器技术、嵌入式计算技术、分布式信息处理和自组织网技术,可实时感知、采集、处理、传输网络分布区域内的各种信息数据,在军事国防、生物医疗、环境监测、抢险救灾、防恐反恐、危险区域远程控制等领域具有十分广阔的应用前景。 本文研究分析了无线传感器网络的已有路由协议,并针对大规模的无线传感器网络设计了一种树状路由协议,它根据节点地址信息来形成路由,从而简化了复杂繁冗的路由表查找和维护,节省了不必要的开销,提高了路由效率,实现了快速有效的数据传输。 为支持此路由协议本文提出了一种自适应动态地址分配算——ADAR(AdaptiveDynamicAddre...As one of the ten high technologies in the future, wireless sensor network, which is the integration of micro-sensors, embedded computing, modern network and Ad Hoc technologies, can apperceive, collect, process and transmit various information data within the region. It can be used in military defense, biomedical, environmental monitoring, disaster relief, counter-terrorism, remote control of haz...学位:工学硕士院系专业:信息科学与技术学院通信工程系_通信与信息系统学号:2332007115216
Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries
- Author
- Abad-Motos Ane
- Abbas Ahmed M.
- Abbas Mostafa
- Abbasi Mujeeb
- Abbott Tom
- Abd Karim Muhammad Fairuz Shah
- Abdalaal Ibrahim
- Abdel-Galil Khalid
- Abdelemam Rania
- Abdelgawad Abdalrahman
- Abdelkarim Maryam
- Abdelkhalek Mohamed
- Abdelmageed Abdelfatah
- Abdelmawgoud Sherif
- Abdelmohsen Sarah
- Abdelrahman Ahmed Saber
- Abdelrahman Mostafa
- Abdelwahab Khaled
- Abdou Hossam
- Abdulai Darling Ramatu
- Abdulkhaleq Marwa
- Abdullah Bahiyah
- Abdulsalam Khalifa
- Abdulsalam Shuaib
- Abdur-Rahman Lukman
- Abdus-Salam Rukiyat
- Abdussalam Hameedat Opeyemi
- Abebrese John Tabiri
- Abeldaño Ariel
- Abou-Khalil Jad
- Abou-Taleb Hisham
- Abozid Anwaar
- Abozied Hesham
- Abrate Alberto
- Abu-Zaid Ahmed
- Abubakar Mohammed Kabir
- Abud Burçin
- Abuzaid Mohammed
- Adam Albushra Altayeb
- Adamina Michel
- Adamou Harissou
- Adamu Auwal
- Adamu Kabir Musa
- Adanu Kekeli
- Adebara Idowu
- Adebola Oluwaseyi
- Ademuyiwa Adesoji
- Adeniran Abiodun
- Adepiti Akinfolarin
- Aderogba Adeleke Akeem
- Adesunkanmi Abdulhafiz
- Adeyeye Ademola
- Adisa Adewale
- Adjeso Theophilus Justus Kofi
- Ads Adel Mohamed
- Ads Alaa Mohamed
- Adu-Aryee Nii Armah
- Adumah Collins
- Afzal Irrum
- Agapov Mikhail
- Agarwal Gaurav
- Agarwal Ravi
- Agbeko Anita Eseenam
- Agbeno Evans Kofi
- Agbonrofo Peter
- Agboola Oluseyi
- Aggarwal Gaurav
- Aghadi Ifeanyi
- Aghtarafi Natasha
- Agrawal Amit
- Agresta Ferdinando
- Aguado Héctor J.
- Aguilera-Arevalo Maria-Lorena
- Aherne Thomas
- Ahmad Aline
- Ahmad Maleeha
- Ahmad Misbahu
- Ahmad Sarwat
- Ahmad Shahzaib
- Ahmad Shoaib
- Ahmed Hayat Tarig Abdelhafiz
- Ahmed Khalid
- Ahmed Sharwany
- Ahmed Shima
- Ahmed Usama
- Aisuodionoe-Shadrach Oseremen
- Aitken Sarah
- Ajenifuja Kayode
- Ajiya Abdulrazak
- Akeel Nouf
- Akin Emrah
- Akinajo Opeyemi
- Akinyemi Tosin
- Akrida Ioanna
- Aktokmakyan Talar Vartanoglu
- Akwaisah Ayoub
- Al Bettar Osama
- Al-Badawi Ismail A.
- Al-Juaifari Maytham
- Al-Khyatt Waleed
- Al-Mallah Abdullah
- Al-Nusairi Ahmed
- Al-Saadi Nina
- Al-Sayaghi Khaled
- Al-Shaiji Tariq
- Al-Shehari Mohammed
- Al-Touny Aiman
- Al-Touny Shimaa A.
- Aladawi Omar
- Aladna Abdallah
- Alali Mahmoud
- Alam Mahmood
- Alam Mohammed Shadrul
- Alarabi Rehab
- Alawneh Yazan
- Alayande Barnabas
- Albanese Erminia
- Albayadi Eslam
- Albdour Maram
- Alconchel Felipe
- Alderazi Amer
- Alegbeleye Bamidele
- Alekberli Tural
- Alemu Misganaw Alemu Adimass
- Alexander Philip
- Alfieri Alex
- Algahtany Khaled
- Algarni Kamal
- Alhamad Ameen
- Alhamid Mohammad
- Alharmi Rawan A. Rahman
- Alharthi Mohammed
- Alhazmi Barrag
- Ali Mohamed Shafi Mahboob
- Ali Stephen
- Alibrahim Hidar
- Aljaaly Hattan
- Aljaiuossi Anas
- Aljanadi Firas
- Aljiffry Murad
- Aljirdabi Noof
- Alkahlan Mohammed
- Alkhalifa Elmustafa
- Alkhatib Sondos
- Alkhatieb Maram
- Allan Anna
- Almarshad Felwa
- Almgla Naser
- Almhimid Ali
- Almiqlash Bushray
- Almoshantaf Mohammad Badr
- Almutairi Abdulmjeed
- Alnsour Abed Alfattah Mahmoud
- Alobied Majd
- Alomar Osama
- Alonso Jesús Aarón Martínez
- Alonso Manuel Diez
- Alonso Nestor Fabian Pedraza
- Alonso Veronica
- Alqallaf Abdullah
- Alqaseer Asma
- Alrayes Bourhan
- Alsefri Maryam
- Alser Osaid
- Alsharif Mohammed
- Alsori Mohamed
- Altaf Abdulmalik
- Altinel Yuksel
- Altiner Saygin
- Altouny Ahmad
- Altun Demet
- Alvarez Natalia
- Alvarez-Lozada Luis Adrian
- Alvi Abdul
- Alwael Athari
- Alwash Mohammed
- Alyami Ziyad
- Alyousef Mohammed
- Alzahrani Saud
- Alzerwi Nasser
- Amin Shivang
- Amir Mohammed
- Ammar Ahmed Siddique
- Ammendola Michele
- Amores Remedios Revilla
- Amrayev Sultan
- Anastasiadou Sofia
- Ancans Guntis
- Anderson Caroline
- Andreani Lorenzo
- Andreotti Dario
- Andreuccetti Jacopo
- Andrianakis Alexandros
- Andro Christophe
- Anesi Alexandre
- Angamuthu Stephen
- Angeles Martina Aida
- Angelico Roberta
- Angelis Fragkiskos
- Angelou Dimitrios
- Angelou Kyveli
- Angulo Victor Pinto
- Anjum Arfa
- Anjum Muhammad Ayyub
- Annicchiarico Alfredo
- Anoldo Pietro
- Ansaloni Luca
- Anthoulakis Christos
- Antonelli Amedeo
- Anwar Mohamed
- Anwar Sumadi Lukman
- Anwer Mariyah
- Anyanwu Lofty-John
- Apostolou Christos
- Apostolou Konstantinos
- Appiah-Kubi Adu
- Aprea Giovanni
- Arbab Hana
- Archer James
- Ardura Francisco
- Aremu Muyiwa
- Arif Tahera
- Arkani Samara
- Armatura Giulia
- Armijos Daniel
- Arnaout Ali
- Arnaoutoglou Eleni
- Arnaud Alexis P.
- Arneja Jugpal
- Arrangoiz Rodrigo
- Arshad Muhammad
- Arthur Joshua
- Ashcroft James
- Ashford Bruce
- Ashraf Fariha
- Asiimwe Daniel
- Asirifi Samuel Amoako
- Asla Amir
- Aslam Ramisha
- Aspide Raffaele
- Ataya Karim
- Ateca Ibabe Villalabeitia
- Atici Semra Demirli
- Atis Gokhan
- Atkins William
- Atkinson Kate
- Attwood Joseph
- Auerkari Aino
- Augestad Knut Magne
- Augustin Goran
- Aujayeb Avinash
- Avella Pasquale
- Awad Ahmed K.
- Awad Hadeel
- Awad Rabih
- Awad Selmy
- Ayad Kusay
- Ayana Birhanu
- Aydin Yener
- Ayeni Funbi
- Aytac Erman
- Azab Ahmed
- Azami Rizwan
- Azize Diallo Abdoul
- Azzam Ahmed Y.
- Azzis Olivier
- Baba Yabasin Iddrisu
- Babis George
- Bacalbasa Nicolae
- Badiani Sarit
- Badran Saif
- Baduell Albert
- Baeesa Saleh
- Baertschiger Reto
- Bafaquh Mohammed
- Bahassan Omar Mohammed
- Bahrami-Hessari Michael
- Baia Marco
- Baidoo Ebikela Ivie
- Bailey Karen
- Baili Efstratia
- Bains Lovenish
- Baiocchi Gian Luca
- Baiocchi Glauco
- Baiyewu Lateef Ayodele
- Bajaj Ankur
- Bajunaid Khalid
- Balagobi Balasingam
- Balasubramanian Ishwarya
- Balduzzi Alberto
- Baldwin Alexander
- Balla Andrea
- Balogh Zsolt J.
- Balogun James A.
- Balogun Simon
- Baloyiannis Ioannis
- Ban Vin Shen
- Bandyopadhyay Samik Kumar
- Bandyopadhyay Soham
- Banerjee Sumit
- Banipal Gurpreet Singh
- Banky Balazs
- Bannone Elisa
- Bansal Sujesh
- Barberis Andrea
- Barbosa-Breda Joao
- Bareka Metaxia
- Barišić Tatjana
- Barlas Aziz Mutlu
- Barlow Ciaran
- Barmayehvar Behrad
- Baroffio Paolo
- Barone Mirko
- Barra Fabio
- Barranquero Alberto G.
- Barugola Giuliano
- Basendowah Mohammed
- Bashir Mahmod
- Basnayake Oshan
- Bass Gary Alan
- Basu Somprakas
- Bateman Antony
- Bateman Kellie
- Batista Sylvia
- Batstone Martin
- Bauer Marlies
- Bauset Juan Carlos Catalá
- Bawa Ashvind
- Bawa Sayesha
- Bayhan Hüseyin
- Bayo Heura Llaquet
- Bazzi Nagham
- Beamish Andrew
- Beasley Nigel
- Beatty Jasmine Winter
- Becerra Angel
- Bedada Alemayehu Ginbo
- Bedzhanyan Arkady
- Begum Farzana
- Beisenov Bekzat
- Bellio Gabriele
- Bello Usman Mohammed
- Bellés Ana Ciscar
- Belzile Etienne
- Benamar Safia
- Bence Matthew
- Benshetrit Guy
- Bensoltane Khadidja
- Bergkvist David Julià
- Beristain-Hernandez Jose-Luis
- Bernante Paolo
- Bernardi Daniele
- Beron Reinaldo Isaacs
- Berselli Bruno
- Berselli Mattia
- Bertelli Giacomo
- Bertoglio Pietro
- Bertolaccini Luca
- Beswick Daniel
- Bette Birgit
- Bezirci Rifat
- Bhangu Aneel
- Bharathan Rasiah
- Bhat Vivek
- Bhatti Khalid
- Bianchi Valentina
- Bianco Francesco
- Bianco Giuseppe
- Bijou Walid
- Bilfaqirah Majed
- Biloslavo Alan
- Bin Alhassan Baba Alhaji
- Binnawara Muhannud
- Bissacco Daniele
- BİŞGİN TAYFUN
- Blair James
- Blanco Jose
- Blencowe Natalie
- Bloemers Frank
- Board Timothy
- Bobak Peter
- Boccalatte Luis
- Boedo Maria Jesus Maroño
- Bohmer Rob
- Boira Mar Achalandabaso
- Boisson Matthieu
- Boligo Sofia
- Bolton William
- Bombardini Cristina
- Bonavina Luigi
- Bonci Eduard-Alexandru
- Bondurri Andrea
- Bonilla Antonio Ramos
- Bonsaana Gilbert Batieka
- Booth L.
- Borg Elaine
- Borges Miguel Fróis
- Borges Nuno
- Bork Ulrich
- Borselle Dominika
- Bortul Marina
- Botelho Pedro
- Bottari Andrea
- Bouchagier Konstantinos
- Bouliaris Konstantinos
- Bowan Antoinette Bediako
- Bowen Joel
- Bozbiyik Osman
- Bracale Umberto
- Brachini Gioia
- Bramis Konstantinos
- Branagan Graham
- Branzan Daniela
- Brasset Camille
- Bratus Dejan
- Bravo Ana Maria Minaya
- Bravo Sybil Lizanne
- Bright Tim
- Brisinda Giuseppe
- Brodkin Edgar
- Broglia Alessandro
- Brolese Alberto
- Browning Rebecca
- Bruzzaniti Placido
- Brzeszczyński Filip
- Bsisu Isam
- Bua Emmanuel
- Budd Gabrielle
- Bukhari Syed Imran
- Bulian Dirk Rolf
- Bumbasirevic Uros
- Bumber Boris
- Burgos-Blasco Barbara
- Burlov Nikita
- Bussu Francesco
- Bàmbina Fabrizio
- Börner Nikolaus
- Böttcher Arne
- Cabeza Leticia
- Cabrera Marino
- Cais Simon
- Cakmak Guldeniz Karadeniz
- Calabretto Francesca
- Calabrò Marcello
- Calavia Pablo
- Calculli Federica
- Calini Giacomo
- Callan Rory
- Callcut Rachael
- Calu Valentin
- Calvache Jose Andres
- Calvache Nieto
- Calvo Francisco Javier Redondo
- Cama Jitoko
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- Camarena Ana Isabel Avellaneda
- Camargo-Parra Katherin
- Cammarata Emanuele
- Cammarata Francesco
- Cammarata Roberto
- Campagnaro Tommaso
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- Cano-Trigueros Emiliano
- Capella Stefano
- Capitan-Morales Luis-Cristobal
- Capobianco Mattia
- Capolupo Gabriella Teresa
- Capozzi Enrico
- Cappuccio Micaela
- Capuano Marianna
- Carannante Filippo
- Carbone Fabio
- Carbone Ludovico
- Caretto Marta
- Caricato Chiara
- Caricato Marco
- Carpenter Holly
- Carreras-Castañer Anna
- Carretero Manuel Moriche
- Caruana Edward J.
- Carvello Michele
- Casagranda Biagio
- Cassese Gianluca
- Cassinotti Elisa
- Castagnini Francesco
- Castaldi Antonio
- Castaño Mario
- Castaño-Leon Ana M.
- Castillo Dayan Fanery Campino
- Castillo Monica Noguez
- Castro Ernes John
- Catarzi Lisa
- Caubet Maria Mercedes
- Caziuc Alexandra
- Ceelen Wim
- Celik Burak
- Cerovac Anis
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- Kauppila Joonas H
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- Zimak Danijela Mrazovac
- Zimak Zoran
- Zivkovic Dragana
- Zizzo Maurizio
- Zucker Benjamin
- Zwain Yasir
- Zyskowski Michael
- Ávila Clara Castro
- Älgå Andreas
- Çakici Mehmet Çaǧlar
- Çelik Enes
- Çelik Meryem Nur
- Özçay Necdet
- Şevik Hüsnü
- Šantak Goran
- Šimko Kristián
- Žatecký Jan
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2023
- Field of study
Abstract
Background
Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres.
Methods
This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries.
Results
In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia.
Conclusion
This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries
A taxonomic bibliography of the South American snakes of the Crotalus durissus complex (Serpentes, Viperidae)
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- A ST
- ABALOS JW
- ABALOS JW
- ABALOS JW
- ABALOS JW
- ABUYS A
- ABUYS A
- ACHAVAL F
- ACHAVAL F
- ACHAVAL F
- ACHAVAL F
- ACHAVAL F
- ACHAVAL F
- ACOSTA S
- ALEMAN-G C
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- ALLEN ER
- AMARAL A
- AMARAL A
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- ANDERSSON LG
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- ANDRADA E SILVA J. B. D'
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- BERTONI AW
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- BISBAL-E. FJ
- BLAIR WF
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- BOESEMAN M
- BOETTGER O.
- BOIE F
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- BONNATERRE JP
- BORY DE SAINT-VINCENT JBGM
- BOULENGER GA
- BOULENGER GA
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- BRADLEY R.
- BRATTSTROM BH
- BRAZIL V
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- CASTELNAU F
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- CATESBY M
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- CHACE GE
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- FREIBERG MA
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Velo Upgrade, summer student programme
- Author
- Publication venue
- Publication date
- 09/08/1998
- Field of study
As part of the LHCb upgrade, the VElO, LHCb innermost detector, is replaced by a new silicon pixel detector. The totally new readout chain has to be developed, tested and debugged thanks to scripts and tools that I help developing as a summer student
Effetto dell'espressione di alfa-sinucleina sul quadro di espressione proteica in un modello cellulare inducibile
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- Publication venue
- Publication date
- 01/01/2001
- Field of study
Global variation in postoperative mortality and complications after cancer surgery: a multicentre, prospective cohort study in 82 countries
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- A. Adam M.
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- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2021
- Field of study
Background: 80% of individuals with cancer will require a surgical procedure, yet little comparative data exist on early outcomes in low-income and middle-income countries (LMICs). We compared postoperative outcomes in breast, colorectal, and gastric cancer surgery in hospitals worldwide, focusing on the effect of disease stage and complications on postoperative mortality. Methods: This was a multicentre, international prospective cohort study of consecutive adult patients undergoing surgery for primary breast, colorectal, or gastric cancer requiring a skin incision done under general or neuraxial anaesthesia. The primary outcome was death or major complication within 30 days of surgery. Multilevel logistic regression determined relationships within three-level nested models of patients within hospitals and countries. Hospital-level infrastructure effects were explored with three-way mediation analyses. This study was registered with ClinicalTrials.gov, NCT03471494. Findings: Between April 1, 2018, and Jan 31, 2019, we enrolled 15 958 patients from 428 hospitals in 82 countries (high income 9106 patients, 31 countries; upper-middle income 2721 patients, 23 countries; or lower-middle income 4131 patients, 28 countries). Patients in LMICs presented with more advanced disease compared with patients in high-income countries. 30-day mortality was higher for gastric cancer in low-income or lower-middle-income countries (adjusted odds ratio 3·72, 95% CI 1·70–8·16) and for colorectal cancer in low-income or lower-middle-income countries (4·59, 2·39–8·80) and upper-middle-income countries (2·06, 1·11–3·83). No difference in 30-day mortality was seen in breast cancer. The proportion of patients who died after a major complication was greatest in low-income or lower-middle-income countries (6·15, 3·26–11·59) and upper-middle-income countries (3·89, 2·08–7·29). Postoperative death after complications was partly explained by patient factors (60%) and partly by hospital or country (40%). The absence of consistently available postoperative care facilities was associated with seven to 10 more deaths per 100 major complications in LMICs. Cancer stage alone explained little of the early variation in mortality or postoperative complications. Interpretation: Higher levels of mortality after cancer surgery in LMICs was not fully explained by later presentation of disease. The capacity to rescue patients from surgical complications is a tangible opportunity for meaningful intervention. Early death after cancer surgery might be reduced by policies focusing on strengthening perioperative care systems to detect and intervene in common complications. Funding: National Institute for Health Research Global Health Research Unit