Design and synthesis of handles for solid-phase peptide synthesis and convergent peptide synthesis

The recent popularity of methods for solid-phase peptide synthesis that use the 9-fluorenylmethyloxycarbonyl (Fmoc) group for Nα-amino protection has created a need for compatible anchoring linkages and handles. In an effort to develop mild new methods for use in solid-phase peptide synthesis (SPPS), a new ferrocene containing linker or “handle”, the 1’1-ferrocenyl carboxaldehyde handle was designed, synthesized, characterized and tested. This linker is analogous to those commercially available and developed by Barany. The ferrocenyl amine linker(FAL) releases C-terminal peptide amides upon acidolysis. Since the FAL handle is acid labile it is compatible with Fmoc and Nα-dithiasuccinoyl (Dts) based chemistries, but not Nα-tert-butyloxycarbonyl (Boc) based chemistries. The solid-phase linkage was investigated based on the stability of the ferrocenium ion. The stability of this ion is greater than that of the benzyl cations that are used in the handles developed previously

The first record of the Indo-Pacific benthic ctenophore Coeloplana (Benthoplana) meteoris (Ctenophora: Coeloplanidae) in the ArabianPersian Gulf

This report presents the first occurrence of the Indo-Pacific benthic ctenophore Coeloplana (Benthoplana) meteoris (Thiel, 1968) in the western part of the Arabian-Persian Gulf, extending its range to 2000km, a record that illustrates a cyclic event observed in the Marine Arabic Province. The seasonal biodiversity influx of invertebrates from the Indian Ocean that establish themselves for a short period of time in the west of the Gulf before the extreme high temperatures takes place in the summer.This publication was made possible by the internal Project Award within the Environmental Science Centre at Qatar University entitled “Qatar’s Marine Bio-Bank” that aimed to identify and save a marine collection, the marine biodiversity of the Qatar Marine Zon

AGN spiral galaxies in groups: effects of bars

AIMS: We explore properties of barred active spiral galaxies in groups and clusters selected from the Sloan Digital Sky Survey data release 7 (SDSS-DR7), with the aim of assessing the effects of bars on active galactic nuclei (AGN) and the role of the high density environment. METHODS: We identified barred active galaxies that reside in groups and clusters by cross-correlating the total barred AGN sample with the SDSS-DR7 group catalog. With the goal of providing a suitable quantification of the effects of bars, a reliable control sample of unbarred active galaxies in high density environments with similar redshift, magnitude, morphology, and bulge size distributions was also constructed. RESULTS: We found that the fraction of barred AGN galaxies in groups and clusters (≈38%) is higher than those in the total barred AGN sample (≈28%), indicating that AGN spiral galaxies in groups are more likely to be barred than those in the field. We also found that barred AGN galaxies are more concentrated towards the group centers than the other unbarred AGN group members. In addition, barred AGN host galaxies show an excess of population dominated by red colors, with respect to the control sample, suggesting that bars produce an important effect on galaxy colors of AGN hosts. The groups of AGN galaxies with and without bars show similar virial masses; however, the host groups of the barred AGN exhibit a larger fraction of red colors than the host groups of the corresponding unbarred active galaxies in the control sample. Color-magnitude relations of both host groups of AGN differ significantly: the host group colors of barred active galaxies display distributions spreading toward red populations, at the same (Mr)Group, with respect to the host groups of the unbarred AGN objects. This trend is more significant in less massive groups than in groups with MVirial> 1013.5M⊙. Barred active galaxies show an excess of nuclear activity compared to galaxies without bars in the control sample. We found that barred active galaxies located farther from the group-center have stronger Lum[OIII], while the nuclear activity in AGN galaxies without bars remain approximately constant with the group-centric distance. In addition, for both AGN samples, nuclear activity increases in bluer host groups however, barred active objects systematically show higher Lum[OIII] values, irrespective of the global group colors. Our findings suggest that the efficiency of bars to transport material towards the more central regions of the AGN galaxies in high density environments reveals an important dependence on the localization of objects within the group/cluster and on the host group colors.Fil: Alonso Giraldes, Maria Sol. Universidad Nacional de San Juan. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Coldwell Lloveras, Georgina Vanesa. Universidad Nacional de San Juan. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Garcia Lambas, Diego Rodolfo. Universidad Nacional de San Juan. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Astronomía Teórica y Experimental. Universidad Nacional de Córdoba. Observatorio Astronómico de Córdoba. Instituto de Astronomía Teórica y Experimental; Argentin

Recognizing Panulirus meripurpuratus sp. nov. (Decapoda: Palinuridae) in Brazil—Systematic and biogeographic overview of Panulirus species in the Atlantic Ocean

Genetic analysis divides Panulirus argus into two different species, physically separated by the Amazon-Orinoco plume since the Last Glacial Maximum. Panulirus argus sensu stricto is distributed north of this biogeographic barrier and the second species to the south, occurring in Brazil. The Panulirus species in the Atlantic Ocean are being overfished and the standing stocks are unknown and still not considered endangered or threatened due to a deficiency of precise abundance data. The lack of data makes it impossible to undertake an effective conservation and management policy. In order to assist in the future management and conservation of the Spiny Lobster in the Atlantic Ocean and particularly for the indigenous species from Brazilian waters, this study formally recognizes and describes a new species, Panulirus meripurpuratus sp. nov., for what was previously known as P. argus in Brazilian waters, and differentiates it from Panulirus argus from North American waters and the Caribbean Sea. The work also presents an overview of the biogeographic distribution of the species and presents two identification keys to Atlantic species, one based on morphology and the other on live colouration

Decapod assemblages in subtidal and intertidal zones - importance of scuba diving as a survey technique in tropical reefs, Brazil

AbstractDecapods play a crucial role within the reef ecosystem and the development of scuba diving as a survey tool has allowed researchers the opportunity to study the decapod–reef relationship more comprehensively. The present study describes the differences in decapod assemblages in intertidal and subtidal zones at a tropical coastal reef system in the southwestern Atlantic Ocean and reports the importance of scuba diving as a survey technique. A total of 71 decapods were recorded during the research; 42 in the intertidal zone mainly formed by small endobenthic species and 39 in the subtidal zone primarily large species only 10 were found to frequent both sample zones. The study extends the range of Brachycarpusholthuisi Fausto Filho 1966 in Brazil; and also demonstrates how scuba diving can be used to complement traditional methodologies and vice versa. The research shows the advantages of using scuba diving when studying trade endangered decapods, as the methodology allows access to cryptic habitats such as reef caves and underwater cavities which were inaccessible when using traditional techniques. In conclusion scuba diving represents a revolutionary non-destructive survey tool allowing the researcher to directly access a specific decapod assemblage in fragile reef environments and in protected marine areas

Talking about quality improvement : impacts of communication and quality management on hospital management : an empirical study

The current aging demographic challenges societies to develop structures that meet their physical and psycho-emotional needs. Nevertheless, the frequent use of medical services and or hospital units overload the system, causing a shortage of resources that may compromise the quality and safety of care for users. The study I am presenting aims to verify the contributions of a Quality Management System in the communication practices of CHO and thus contribute to improving patient safety. Twenty-nine health professionals were interviewed, distributed among different professional categories. The results showed that the means of communication used among professionals are multiple, existing information overload and or communication failure that are potentially harmful to the patient's safety. All interviewees recognize the need to improve the communication process in order to optimize its effectiveness. The implementation of a QMS can contribute to the improvement of the CHO's communication practices. Once the QMS is implemented and internalized in an organization, the improvements in results are evident. Quality management systems are important for the continuous improvement of any organization, optimizing its resources and improving its performance.O envelhecimento demográfico desafia as sociedades mundiais a desenvolver estruturas que respondam às suas necessidades bio psicosocioemocionais. O recurso frequente a unidades hospitalares sobrecarrega o sistema, originando escassez de recursos, e comprometendo a qualidade / segurança dos utentes. O estudo que apresento pretende verificar os contributos de um Sistema de qualidade de gestão nas práticas de comunicação do CHO e assim contribuir para melhorar a segurança dos pacientes. É de abordagem qualitativa, a colheita de dados foi efetuada através de entrevista telefónica, devido ao contexto atual de pandemia COVID. Foram entrevistados 29 profissionais de saúde, distribuídos por diversas categorias profissionais. Os resultados demonstraram que os meios de comunicação utilizados entre os profissionais são múltiplos, existindo sobrecarga de informação e ou falha de comunicação que são potencialmente prejudiciais à segurança do utente. Todos os entrevistados reconhecem a necessidade de melhorar o processo comunicacional de forma a otimizar a sua eficácia. A implementação de um SGQ pode contribuir na melhoria das práticas de comunicação do CHO. Uma vez que quando implementado e interiorizado o SGQ numa organização, as melhorias dos resultados são evidentes. Os sistemas de gestão de qualidade são importantes para a melhoria contínua de qualquer organização, otimizando os seus recursos e melhorando o seu desempenho

Occurrence of LINER galaxies within the galaxy group environment

We study the properties of a sample of 3967 low-ionization nuclear emission-line region (LINER) galaxies selected from SDSS-DR7, with respect to their proximity to galaxy groups. The host galaxies of LINERs have been analysed and compared with a well-defined control sample of 3841 non-LINER galaxies matched in redshift, luminosity, colour, morphology, age and stellar mass content. We find no difference between LINER and control galaxies in terms of the colour and age of stellar population as a function of the virial mass and distance to the geometric centre of the group. However, we find that LINERs are more likely to populate low-density environments in spite of their morphology, which is typical of high-density regions such as rich galaxy clusters. For rich (poor) galaxy groups, the occurrence of LINERs is approximately two times lower (higher) than the occurrence of matched, non-LINER galaxies. Moreover, LINER hosts do not seem to follow the expected morphology–density relation in groups of high virial mass. The high frequency of LINERs in low-density regions could be due to the combination of a sufficient gas reservoir to power the low-ionization emission and/or enhanced galaxy interaction rates benefiting the gas flow towards their central regions.Fil: Coldwell Lloveras, Georgina Vanesa. Universidad Nacional de San Juan. Facultad de Ciencias Exactas, Físicas y Naturales. Departamento de Geofísica y Astronomía; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Pereyra, Luis Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Astronomía Teórica y Experimental. Universidad Nacional de Córdoba. Observatorio Astronómico de Córdoba. Instituto de Astronomía Teórica y Experimental; ArgentinaFil: Alonso Giraldes, Maria Sol. Universidad Nacional de San Juan. Facultad de Ciencias Exactas, Físicas y Naturales. Departamento de Geofísica y Astronomía; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Donoso, Emilio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan. Instituto de Ciencias Astronómicas, de la Tierra y del Espacio. Universidad Nacional de San Juan. Instituto de Ciencias Astronómicas, de la Tierra y del Espacio; ArgentinaFil: Duplancic Videla, Maria Fernanda. Universidad Nacional de San Juan. Facultad de Ciencias Exactas, Físicas y Naturales. Departamento de Geofísica y Astronomía; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin

Sport Tv field lab on new product development

This work project consists of an analysis on the company Sport TV, with emphasis on its internal and external environments, as well as its consumers. The final purpose was to find a strategy that could improve the company’s overall competitiveness in the Portuguese market. The identified strategy was new product development, and the work project describes how the company should launch it, by using the 4P’s framework: How should the product be, how to monetize, how to promote and finally how to distribute it

Generalised F-semigroups

Fundação para a Ciência e a Tecnologia (FCT) - POCTI

F −semigroups

A semigroup S is called F−semigroup if there exists a group congruence ρ on S such that every ρ −class contains a greatest element with respect to the natural partial order ≤ of S . This generalizes the concept of F−inverse semigroups introduced by V. Wagner in 1961 and investigated by McFadden and O’Caroll in 1971. Five different characterisations of general F−semigroups S are given: by means of residuals, by special principal anticones, by properties of the set of idempotents, by the maximal elements in (S, ≤) and finally, an axiomatic one using an additional unary operation. Also, F−semigroups in special classes are considered; in particular, inflations of semigroups and strong semi- lattices of monoids are studied.Centro de Matemática da Universidade do MinhoFundação para a Ciência e a Tecnologia (FCT