Improper use of "radioguided occult lesion localization" (ROLL) technique leads to misleading conclusions

No abstract availabl

A RESTful Rule Management Framework for Internet of Things Applications

Web technologies are currently regarded as key enabling factors for the Internet of Things (IoT), and substantial effort is being dedicated to bringing sensors and data from the real world to the Web. In addition, rule-based automation mechanisms are expected to play a significant role in the effective integration of the physical world with the virtual world by leveraging a trigger-action paradigm. Although several rule engines are already available, limited effort has been devoted to rule-based solutions that are tailored to the IoT and consider rule configurability and extensibility according to application requirements. In this work, we propose a RESTful rule management framework for IoT applications that satisfies these requirements. The framework is centered around a resource-based graph, which enables the uniform representation of things (e.g., sensors and domain entities) and rules as URI-addressable resources. We describe the design and implementation choices of the main rule management features (rule scheduling, activation and RESTful operations for managing rules at various levels of configurability and extensibility). Finally, we present a case study and performance evaluation results regarding the use of this rule management framework in a set of school buildings that were part of a real-world IoT deployment that was realized within the Horizon 2020 GAIA research project, with the objective of promoting energy -saving behaviors in school communities

Evaluation of response to immunotherapy: new challenges and opportunities for PET imaging

non present

Intramedullary spinal cord metastases from breast cancer: Detection with 18F-FDG PET/CT

A 35-year-old woman, already treated with surgery, chemotherapy, and radiotherapy for a ductal carcinoma of the left breast, underwent an 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) scan for an increase of the serum markers carcinoembryonic antigen (CEA) and cancer antigen 15.3 (CA15.3). The scan showed multiple FDG-avid lesions in the liver and bone. The images also detected two areas of uptake in the dorsal and lumbar spinal cord, which were suspicious for metastases; magnetic resonance imaging (MRI) confirmed these lesions. © the authors; licensee ecancermedicalscience

Atypical primary pulmonary meningioma: A report of a case suspected of being a lung metastasis

Primary extracranial and extraspinal meningiomas are very rare tumours, and primary pulmonary ones are even more uncommon. They present as a solitary pulmonary nodule, and most of them are benign, except for three cases. We describe a primitive atypical pulmonary meningioma first suspected of being a metastasis in a patient during follow-up ten years after therapy for breast cancer. © the authors; licensee ecancermedicalscience

Peptide Receptor Radionuclide Therapy for Advanced Neuroendocrine Tumors

No abstract availabl

Positron emission tomography in the diagnostic work-up of screening-detected lung nodules

Low-dose computed tomography (CT) screening for lung cancer can reduce lung cancer mortality, but overdiagnosis, false positives and invasive procedures for benign nodules are worrying. We evaluated the utility of positron emission tomography (PET)-CT in characterising indeterminate screeningdetected lung nodules. 383 nodules, examined by PET-CT over the first 6 years of the COSMOS (Continuous Observation of Smoking Subjects) study to diagnose primary lung cancer, were reviewed and compared with pathological findings (surgically-treated patients) or follow-up (negative CT for â\u89¥2 years, considered negative); 196 nodules were malignant. The sensitivity, specificity and accuracy of PET-CT for differentially diagnosing malignant nodules were, respectively, 64%, 89% and 76% overall, and 82%, 92% and 88% for baseline-detected nodules. Performance was lower for nodules found at repeat annual scans, with sensitivity ranging from 22% for nonsolid to 79% for solid nodules (p=0.0001). Sensitivity (87%) and specificity (73%) were high for nodules â\u89¥15 mm, better (sensitivity 98%) for solid nodules â\u89¥15 mm. PET-CT was highly sensitive for the differential diagnosis of indeterminate nodules detected at baseline, nodules â\u89¥15 mm and solid nodules. Sensitivity was low for sub-solid nodules and nodules discovered after baseline for which other methods, e.g. volume doubling time, should be used