Hand-assisted hybrid laparoscopic–robotic total proctocolectomy with ileal pouch–anal anastomosis

PURPOSE: Few studies have reported minimally invasive total proctocolectomy with ileal pouch-anal anastomosis (IPAA) for ulcerative colitis (UC) and familial adenomatous polyposis (FAP). We herein report a novel hand-assisted hybrid laparoscopic-robotic technique for patients with FAP and UC. METHODS: Between February 2010 and March 2014, six patients underwent hand-assisted hybrid laparoscopic-robotic total proctocolectomy with IPAA. The abdominal colectomy was performed laparoscopically with hand assistance through a transverse suprapubic incision, also used to fashion the ileal pouch. The proctectomy was carried out with the da Vinci Surgical System. The IPAA was hand-sewn through a trans-anal approach. The procedure was complemented by a temporary diverting loop ileostomy. RESULTS: The mean hand-assisted laparoscopic surgery (HALS) time was 154.6 (±12.8) min whereas the mean robotic time was 93.6 (±8.1) min. In all cases, a nerve-sparing proctectomy was performed, and no conversion to traditional laparotomy was required. The mean postoperative hospital stay was 13.2 (±7.4) days. No anastomotic leakage was observed. To date, no autonomic neurological disorders have been observed with a mean of 5.8 (±1.3) bowel movements per day. CONCLUSIONS: The hand-assisted hybrid laparoscopic-robotic approach to total proctocolectomy with IPAA has not been previously described. Our report shows the feasibility of this hybrid approach, which surpasses most of the limitations of pure laparoscopic and robotic techniques. Further experience is necessary to refine the technique and fully assess its potential advantages

Sexual and urinary functions after robot-assisted versus pure laparoscopic total mesorectal excision for rectal cancer

Background Laparoscopic total mesorectal excision (LapTME) is a validated technique for the treatment of rectal cancer. However, the ergonomic limitations of pure laparoscopy could lead to high conversion rates and a high rate of autonomic disorders. For these reasons the robot-assisted TME (RobTME) has been proposed to overcome the limitations of LapTME. The aim of this study is to compare surgical outcomes, medium-term oncologic results, and postoperative autonomic function of LapTME versus RobTME, in a single surgeon experience. Patients and Methods The first 26 LapTME were compared with the first 26 RobTME performed by a single surgeon between January 2009 and May 2013. Perioperative outcomes were prospectively collected and compared. The impact of minimally invasive TME on autonomic function and quality of life (QOL) was analyzed with the ICIQ-FLUTS and the ICIQ-MLUTS (International Consultation on Incontinence–Male/Female Lower Urinary Tract Symptoms) and IIEF (International Index of Erectile Function)/FSFI (Female Sexual Function Index) questionnaires. Pathological aspects and oncological outcomes were also collected. Results Of the 26 LapTME, 22 were anterior resections (ARR), 2 intersphincteric resections (ISR), and 2 abdominoperineal resections (APR), while of the 26 RobTME, 17 were ARR, 5 ISR, and 4 APR. Mean operative time was significantly higher (p<0.001) while conversion rate to hand-assisted or open surgery was significantly lower in the robTME group (p<0.05). There were no significant differences in sexual and urinary scores between the two groups before surgery and at 1 year after surgery. There were no differences in 3 year overall survival, disease free survival, and recurrence rate as well as the other parameters analysed. Conclusion RobTME is a safe and effective technique and the results compare favourably to the results obtained with laparoscopic procedures. It seems a promising alternative to preserve autonomic function and results in a low conversion rate even when used for more high risk procedures such as ISR or APR

Pancreatoduodenectomy without vascular resection in patients with primary resectable adenocarcinoma and unilateral venous contact:A matched case study

Purpose. To investigate the oncological outcome and survival of patients following a conservative approach on the portal- mesenteric axis, in an intraoperative ultrasound-selected group of pancreatoduodenectomy (PD), performed on patients with primary resectable with vascular contact (prVC) pancreatic ductal adenocarcinoma (PDAC). Methods. A consecutive series of patients who underwent PD for PDAC at our tertiary care center, between 2008 and 2017, were reviewed. A total of 156 PDs and 88 total pancreatectomies were performed during the study period, including 35 vascular resections. We identified a group of 40 (25.6%) patients with prVC-PDAC in whom after checking the feasibility with intraoperative ultrasound, we were able to perform PD by separation of the tumor from the portomesenteric axis avoiding vascular resection, without residual macroscopic disease (no vascular resection, nvrPD), and compared this group, using case-matched methodology, with the standard PD (sPD) group of primary resectable without vascular contact- (prwVC-) PDAC. Results. The median follow-up was 28.5 ± 23.2 months in the sPD group and 23.8 ± 20.8 months in the nvrPD group (p = 0 35). Isolated local recurrence rate was 2/40 (5%) in both groups. Additionally, there were no statistical differences in the systemic progression of the disease (42.5% sPD vs. 45% nvrPD, p = 0 82) or local plus synchronous systemic disease rates (2.5% sPD vs. 7.5% nvrPD, p = 0 30). The median survival was 22 months for the sPD group and 23 months for the nvrPD group, p = 0 86. The overall survival was similar in the two groups (1 y: 76.3% sPD vs. 70.0% nvrPD; 3 y: 35.6% vs. 31.6%; and 5 y: 28.5% vs. 25.3%; p = 0 80). Conclusions. PD without vascular resection can be considered safe and oncologically acceptable in selected patients with preoperative diagnosis of prVC-PDAC. The poor prognosis of PDAC is related to the aggressive biology and systemic spread of the tumor, rather than the local control of the disease

News from the “5th international meeting on inflammatory bowel diseases” CAPRI 2010

AbstractAt the “5th International Meeting on Inflammatory Bowel Diseases selected topics of inflammatory bowel disease (IBD), including the environment, genetics, the gut flora, the cell response and immunomodulation were discussed in order to better understand specific clinical and therapeutic aspects. The incidence of IBD continues to rise, both in low and in high-incidence areas. It is believed that factors associated with ‘Westernization’ may be conditioning the expression of these disorders. The increased incidence of IBD among migrants from low-incidence to high-incidence areas within the same generation suggests a strong environmental influence.The development of genome-wide association scanning (GWAS) technologies has lead to the discovery of more than 100 IBD loci. Some, as the Th 17 pathway genes, are shared between Crohn's disease (CD) and ulcerative colitis (UC), while other are IBD subtype-specific (autophagy genes, epithelial barrier genes). Disease-specific therapies targeting these pathways should be developed. Epigenetic regulation of the inflammatory response also appears to play an important role in the pathogenesis of IBD.The importance of gut flora in intestinal homeostasis and inflammation was reinforced, the concepts of eubiosis and dysbiosis were introduced, and some strategies for reverting dysbiosis to a homeostatic state of eubiosis were proposed. The current status of studies on the human gut microbiota metagenome, metaprotome, and metabolome was also presented.The cell response in inflammation, including endoplasmic reticulum (ER) stress responses, autophagy and inflammasome-dependent events were related to IBD pathogenesis. It was suggested that inflammation-associated ER stress responses may be a common trait in the pathogenesis of various chronic immune and metabolic diseases.How innate and adaptive immunity signaling events can perpetuate chronic inflammation was discussed extensively. Signal transduction pathways provide intracellular mechanisms by which cells respond and adapt to multiple environmental stresses. The identification of these signals has led to a greater mechanistic understanding of IBD pathogenesis and pointed to potentially new therapeutic targets.A critical analysis of clinical trials and of risk-benefit of biological therapy was presented. The problem of Epstein–Barr virus (EBV) and lymphoma in IBD was extensively discussed. Lymphomas can develop in intestinal segments affected by IBD and are in most cases associated with EBV. The reasons of treatment failure were also analyzed both from basic and clinical points of view.Two very interesting presentations on the integration of research and clinical care in the near future closed the meeting. These presentations were focused on macrotrends affecting healthcare delivery and research, and the need to innovate traditional infrastructures to deal with these changing trends as well as new opportunities to accelerate scientific knowledge

EARLY EXPERIENCE OF FULL ROBOTIC COLORECTAL RESECTIONS FOR CANCER COMBINED WITH OTHER MAJOR SURGICAL PROCEDURES WITH THE NEW DA VINCI XI

PURPOSE The new da Vinci Xi® has been developed and released to overcome some of the limitations of the previous platform, therefore increasing the acceptance of its use in robotic multi-quadrant operations. The new characteristics could have an important role in colon-rectal surgery and particularly in attaining fully robotic colon-rectal resection combined with other major surgical procedures. The aim of this study is to evaluate the pre-operative results of totally robotic colorectal surgery for cancer in association with other major procedures with Da Vinci Xi. METHODS We reviewed the charts of all patients undergoing fully robotic combination procedures involving colon-rectal resections using the Da Vinci Xi, from January 2015 to October 2015. Variables that were examined included patient demographic characteristics, pre-operative data such as trocar position, technical aspects, operative time and robot dock/undocking times. Postoperative variables included the length of hospital stay, morbidity and mortality. Ten patients were included in this study, including 12 colorectal procedures: 5 right hemi-colectomy and 5 anterior rectal resections with TME were performed in combination with sigmoidectomy (1), right nephrectomy (2), hysterectomy (1), hepatic resection (3), enucleation of pancreatic tail lesion (2) and ileo-cecal resection (1). RESULTS All the operations were completed by a fully robotic approach, without conversion to hand assisted laparoscopy or laparotomy, and without hybrid approaches or need of changing of robotic cart position. Trocar positions respected the Universal Port Placement Guidelines provided by Intuitive Surgical for “left lower quadrant”. Simultaneous procedures in the same quadrant or left quadrant and pelvis, or left/right and upper, were performed with a single docking/single targeting approach; in cases of left/right quadrant or right quadrant/pelvis, we performed a dual-docking operation where we re-targeted using the camera to orient the system towards the new work space (an opposite facing quadrant) and re-docked the remaining arms. No external collisions or problems related to trocar positions were noted. Mean overall procedural time was 360 min (±128min). No patient experienced postoperative surgical complications and the mean hospital stay was 6 days (±3days). DISCUSSION In our early experience we were able to complete all procedures with a full robotic approach, without the necessity to associated or convert to a laparoscopic approach. Thanks to the targeting function of the Da Vinci Xi, the robot re-targeting could be enough in combined surgical operation of the same hemi-abdomen. This procedure allows us to obtain a new improved alignment of robotic arms. Instead, in the case of left/right quadrant, it was necessary to re-target using the camera to orient the system towards the new work space (an opposite facing quadrant) with 180°-boom rotation and then re-docked the remaining arms. However, this procedure is simple and not time consuming as it was only necessary to rotate the boom without changing cart’ position. These types of combined surgical procedures were not possible with the da Vinci Si. In fact with the previous system, it was mandatory to undock the robotic arms, disconnect and change the cart’ position in the opposite side of the operating table and finally re-docked the Da Vinci System. These maneuvers leads to both a substantial increase in operating time and difficulties in moving the bulky robotic cart. The limitations of Da Vinci Si were overcome by the new realized product Da Vinci Xi. We tried to suggest an initial proposal for standardized surgical procedures’, trying to define the best trocars’ position for combined surgical operations that would not requires an additional trocar position or problems with instruments collision. In our opinion the trocars’ position described in the this present experience allows us to perform operations in all abdominal quadrants without major movements thus only changing robotic arms’ position, rotating the boom or exploiting the targeting function. In fact, in all cases we were able to perform all surgical procedures without the need of additional robotic trocar, completing the surgical procedure with a full robotic approach and no robotic arms clashing or an excessive time needed for the re-docking was reported. CONCLUSIONS The herein presented high success rate of robotic colorectal resection combined with other surgical interventions for synchronous tumors, without conversion or excessive operating time, suggests the efficacy of the new released product Da Vinci Xi, in minimally invasive multi-quadrant combined surgery. A further possible advantage may be provided by da Vinci Xi Integrated Table Motion feature (available only in the EU), that allows patients to be repositioned without undocking the robot and without removing instruments inside the abdomen

Use of the new Da Vinci Xi® during robotic rectal resection for cancer: technical considerations and early experience

Letter to the edito

Short-term clinical outcomes of robot-assisted intersphincteric resection and low rectal resection with double-stapling technique for cancer: a case-matched study

Background: Intersphincteric resection (ISR) with total mesorectal excision (TME) is an accepted technique for the surgical treatment of very low rectal cancer. Historically it is associated with a higher functional complication rate than the Double Stapling (DS) technique when performed with open or laparoscopic approach. The aim of this study was to compare the surgical, short-term oncologic and functional outcomes of robotic ISR TME (R-ISR-TME) with those of robotic low anterior resection TME with a double stapling technique (R-DS-TME). Methods: Between April 2010 and December 2013, 42 patients underwent robot-assisted rectal resection with TME at our General Surgery Unit, including 10 R-ISR-TME. The outcomes of the R-ISR-TME group were compared with a R-DS-TME group selected using a case-matched methodology. We evaluated the operative, pathological, short-term oncologic results and postoperative sexual, urinary and defecation functions using specific questionnaires. Results: The analyses of the data showed similar results for R-ISR-TME and R-DS-TME regarding the operative, pathological and oncologic results. Focusing on urinary and sexual function, no score values were significantly different at any time between the two groups. The daily frequency of defecation 1 year after surgery was 1.9±0.9 for RISR-TME and 1.8±0.3 for RDS-TME indicating no difference between the two groups. Moreover, there were no significant differences between the two groups in other defecation functions. The mean Wexner score 1 year after surgery was 3.0±1.1 in R-ISR-TME and 2.2±1.0 in R-DS-TME group (p=0.2) and defecation-related quality of life for R-ISR-TME and R-DS-TME was not significantly different (modified fecal incontinence quality of life score: 30.3±19.1 vs 27.5±14.5, respectively; p=0.2). Conclusions: These clinical and functional results suggest that R-ISR-TME could be a good sphincter-preserving surgery for patients with very low rectal cancer. Robotic assistance may overcome some intrinsic limitations of the ISR technique flattening the difference with the DS-TME procedure