Finanziamento e qualità della ricerca nelle università italiane

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Gli italiani e le lingue estere:il caso del servizio biblioteche di Roma (sondaggio)

Il sondaggio rileva la conoscenza degli italiani di una lingua straniera e una sempre maggiore apertura verso le lingue orientali. Inotre analizza quali siano i servizi offerti dalle biblioteche: materiale audio, cartaceo, corsi di lingua e chi tra i fruitori delle biblioteche ne usufruisce di più

The RNA-Binding Protein SMN as a Novel Player in Laryngeal Squamous Cell Carcinoma

Head and neck squamous cell carcinoma (HNSCC) arises from the mucosal epithelium in the oral cavity, pharynx, sino-nasal region, and larynx. Laryngeal squamous cell carcinoma (LSCC) represents one-third of all head and neck cancers. Dysregulated RNA-related pathways define an important molecular signature in this aggressive carcinoma. The Survival Motor Neuron (SMN) protein regulates fundamental aspects of the RNA metabolism but, curiously, its role in cancer is virtually unknown. For the first time, here, we focus on the SMN in the cancer context. We conducted a pilot study in a total of 20 patients with LSCC where the SMN was found overexpressed at both the protein and transcript levels. By a cellular model of human laryngeal carcinoma, we demonstrated that the SMN impacts cancer-relevant behaviors and perturbs key players of cell migration, invasion, and adhesion. Furthermore, in LSCC we showed a physical interaction between the SMN and the epidermal growth factor receptor (EGFR), whose overexpression is an important feature in these tumors. This study proposes the SMN protein as a novel therapeutic target in LSSC and likely in the whole spectrum of HNSCC. Overall, we provide the first analysis of the SMN in human cancer

Evaluating scientific research in Italy: The 2004-10 research evaluation exercise

The Italian Research Evaluation assessment for the period 2004-10 (VQR 2004-10) has analyzed almost 185,000 articles, books, patents, and other scientific outcomes submitted for evaluation by Italian universities and other public research bodies. This article describes the main features of this exercise, introducing its legal framework and the criteria used for evaluation. The innovative methodology that has been used for evaluation, based on a combination of peer review and bibliometric methods, is discussed and indicators for assessing the quality of participating research bodies are derived accordingly. The article also presents the main results obtained at the University level, trying to understand the existing relationship among research quality and University characteristics such as location, dimension, age, scientific specialization, and funding