Sphenopalatine ganglion block with botulinum toxin type A using a three-dimensional injection guide for facial pain of cancerous origin: study of a clinical case.

Objective: Sphenopalatine ganglion block remains a noninvasive therapeutic option to treat diverse facial pain syndromes. The aim of this case report was to verify the effectiveness and safety of three-dimensional (3D) injection guide for sphenopalatine ganglion block in a tongue cancer patient. Case report: A 53-year-old man presented with a large squamous cell carcinoma of the right base of the tongue, classified cT4N2M0 and exhibiting excruciatin facial pain. A botulinum toxin injection was performed following Dr. Yoshida’s method, using a 3D injection guide. Conclusions: Sphenopalatine ganglion block with 3D injection guide can be an effective treatment against cancer pain. In this case report a complete withdrawal of painkillers was obtained less than 24 hours after botulinum toxin injection.Objective: Sphenopalatine ganglion block remains a noninvasive therapeutic option to treat diverse facial pain syndromes. The aim of this case report was to verify the effectiveness and safety of three-dimensional (3D) injection guide for sphenopalatine ganglion block in a tongue cancer patient. Case report: A 53-year-old man presented with a large squamous cell carcinoma of the right base of the tongue, classified cT4N2M0 and exhibiting excruciating facial pain. A botulinum toxin injection was performed following Dr. Yoshida’s method, using a 3D injection guide. Conclusions: Sphenopalatine ganglion block with 3D injection guide can be an effective treatment against cancer pain. In this case report a complete withdrawal of painkillers was obtained less than 24 hours after botulinum toxin injection

Medication-Related Osteonecrosis of the Jaw: New Insights into Molecular Mechanisms and Cellular Therapeutic Approaches

peer reviewedIn recent years, medication-related osteonecrosis of the jaw (MRONJ) became an arising disease due to the important antiresorptive drug prescriptions to treat oncologic and osteoporotic patients, as well as the use of new antiangiogenic drugs such as VEGF antagonist. So far, MRONJ physiopathogenesis still remains unclear. Aiming to better understand MRONJ physiopathology, the first objective of this review would be to highlight major molecular mechanisms that are known to be involved in bone formation and remodeling. Recent development in MRONJ pharmacological treatments showed good results; however, those treatments are not curative and could have major side effects. In parallel to pharmacological treatments, MSC grafts appeared to be beneficial in the treatment of MRONJ, in multiple aspects: (1) recruitment and stimulation of local or regional endogenous cells to differentiate into osteoblasts and thus bone formation, (2) beneficial impact on bone remodeling, and (3) immune-modulatory properties that decrease inflammation. In this context, the second objective of this manuscript would be to summarize the molecular regulatory events controlling osteogenic differentiation, bone remodeling, and osteoimmunology and potential beneficial effects of MSC related to those aspects, in order to apprehend MRONJ and to develop new therapeutic approaches

Le syndrome de Langenbeck: quelles répercussions sur la cinétique mandibulaire ?

Langenbeck syndrome or mandibular coronoid process hyperplasia is a rare disease characterized by an increase in the volume of the coronoid processes. This hyperplasia causes bone conflict with limitation of mouth opening. Surgeons must be awareness of this rare disease, included in differential diagnosis of mouth opening limitation. We present a case successfully treated in our department. Successful management includes both bilateral intra-oral coronoïdectomies and supportive post-operative follow-up with maxillofacial physiotherapy.  Le syndrome de Langenbeck ou hyperplasie des processus coronoïdes mandibulaires est une maladie rare caractérisée par une augmentation de volume des processus coronoïdes. Cette hyperplasie entraîne un conflit osseux limitant l’ouverture buccale. Ce syndrome doit être connu des cliniciens car il entre dans le diagnostic différentiel des limitations d’ouverture buccale. Nous présentons un cas traité avec succès dans notre service. Une prise en charge efficace comporte un versant chirurgical et kinésithérapeutique, qui sont discutés dans notre publication

Glucose and Pharmacological Modulators of ATP-Sensitive K+ Channels Control [Ca2+]c by Different Mechanisms in Isolated Mouse α-Cells

OBJECTIVE—We studied how glucose and ATP-sensitive K+ (KATP) channel modulators affect α-cell [Ca2+]c

Améloblastome unikystique dans le cadre d'un sydrome de Delleman

peer reviewedAmeloblastoma is an odontogenic tumour that represents 1 % of oral tumours but 10 % of odontogenic tumours. Ameloblastoma is characterized by low and noiseless growth, that explains a lot of advanced forms. The tumour is known as benign with local malignity due to its locally invasive behaviour and its recurrence. The treatment choice remains complicated because of recurring nature and large resection in vital anatomical areas. The therapeutic approach will be based on size, anatomical localisation, histologic variants and anatomical complications. The treatment options should be discussed with the patient because of possible important morphological and functional sequelae

How I treat... an anterior temporomandibular joint dislocation

peer reviewedLa luxation antérieure de l’articulation temporo-mandibulaire n’est pas rare et nécessite une prise en charge rapide. Un défaut de réduction de la luxation peut conduire à des atteintes fonctionnelles graves d’une articulation complexe et souvent en activité. La mise au point diagnostique est clinique et relativement évidente. Elle est réalisée par les équipes médicales de première ligne, généraliste ou urgentiste. Les cas récidivants concernent les chirurgiens maxillo-faciaux. Cet article décrit une technique classique de réduction de la luxation antérieure, à réaliser en urgence. La seconde partie de l’article traite de la prise en charge des formes récidivantes, affaire de spécialiste et de leurs techniques chirurgicales.The anterior dislocation of the temporomandibular joint is not uncommon and requires prompt management. A dislocation reduction defect can lead to severe functional impairment of complex joint and often active. The focus is clinical and diagnostically relatively obvious. It is performed by medical teams frontline, general practitioner or Emergency doctor. The recurrent cases are a matter for maxillofacial surgeons. This article describes a conventional technique for anterior dislocation reduction, to achieve urgently. The second part of the article deals with the treatment of relapsing forms, business specialist and their surgical techniques

3D planning : from carcinological resection to maxillofacial reconstruction.

editorial reviewedThe use of new technologies in medicine becomes more and more frequent because they allow us to raise therapeutic quality. This is the case in maxillofacial surgery. 3D planning for oncological resection and reconstruction brings many benefits. In this article, we will present the first case operated with this technology at CHU Liege and discuss the advantages and disadvantages of this technique.L’utilisation des nouvelles technologies en médecine devient de plus en plus fréquente car elles permettent d’augmenter la qualité thérapeutique. C’est le cas dans le domaine de la chirurgie maxillo-faciale. La planification 3D des chirurgies de résection oncologique et de reconstruction apporte de nombreux bénéfices. Dans cet article, nous vous présentons le premier cas opéré grâce à cette technologie au sein du CHU Liège et discutons des avantages et inconvénients de cette technique

Maxillomandibular advancement surgery in severe OSAS

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