10 research outputs found
INFECÇÃO EXPERIMENTAL EM CAPRINOS COM MYCOBACTERIUM PARATUBERCULOSIS DE ORIGEM BOVINA
Corynebacterium renale as a cause of reactions to the complement fixation test for Johne's disease
Complement fixation (C.F.) tests and fluorescent antibody (F.A.) tests were carried out on sera from rabbits inoculated with Corynebacterium renale and Mycobacterium johnei, and on sera from cattle with C. renale pyelonephritis and with Johne's disease. Cross-reactions were a feature of the C.F. test with both antigens on sera from rabbits and cattle with both infections. Positive C.F. tests for Johne's disease could, therefore, result from C. renale infection. The F.A. test was highly specific in the artificially infected rabbits and more specific than the C.F. test in cattle with the natural diseases
The specificity and sensitivity of the fluorescent antibody test in cattle experimentally infected with Mycobacterium avium and Mycobacterium johnei
Susceptibility of specific pathogen-free lambs to concentrations of Pasteurella haemolytica serotype A2 in aerosols
Corynebacterium renale as a cause of reactions to the complement fixation test for Johne's disease
The role of concurrent haemonchosis in the development of pneumonic pasteurellosis in goats
The pharmacokinetics of flunixin meglumine in the sheep
Flunixin meglumine was administered intravenously and intramuscularly in sheep and the pharmacokinetics of the drug studied. Plasma concentrations of flunixin were measured by high performance liquid chromatography. The decline in plasma flunixin concentration with time was best fitted by a triexponential equation. The pharmacokinetics following intravenous administration of 1.0 mg/kg indicate that flunixin has a rapid distribution half-life (t1/2 pi = 2.3 min), a slow body clearance rate (Clb = 0.6 ml/kg/min) and an elimination half-life of 229 min. Similarly, at 2.0 mg/kg, flunixin is rapidly distributed from the plasma, t1/2 pi = 2.7 min, has a slow body clearance rate (Clb = 0.7 ml/kg/min) and an elimination half-life of 205 min. Following intramuscular injection flunixin is rapidly and well absorbed from the injection site. It had a mean maximum concentration (Cmax) of > or = 5.9 micrograms/ml when administered at a dose rate of 1.1 mg/kg, and a relative bioavailability of 70%. Plasma concentrations increase proportionally to dose over the range 1.1 mg/kg-2.2 mg/kg when administered by the intramuscular route.Peer reviewe