5 research outputs found
PIPPI2021: An Approach to Automated Diagnosis and Texture Analysis of the Fetal Liver & Placenta in Fetal Growth Restriction
Fetal growth restriction (FGR) is a prevalent pregnancy condition
characterised by failure of the fetus to reach its genetically predetermined
growth potential. We explore the application of model fitting techniques,
linear regression machine learning models, deep learning regression, and
Haralick textured features from multi-contrast MRI for multi-fetal organ
analysis of FGR. We employed T2 relaxometry and diffusion-weighted MRI datasets
(using a combined T2-diffusion scan) for 12 normally grown and 12 FGR
gestational age (GA) matched pregnancies. We applied the Intravoxel Incoherent
Motion Model and novel multi-compartment models for MRI fetal analysis, which
exhibit potential to provide a multi-organ FGR assessment, overcoming the
limitations of empirical indicators - such as abnormal artery Doppler findings
- to evaluate placental dysfunction. The placenta and fetal liver presented key
differentiators between FGR and normal controls (decreased perfusion, abnormal
fetal blood motion and reduced fetal blood oxygenation. This may be associated
with the preferential shunting of the fetal blood towards the fetal brain.
These features were further explored to determine their role in assessing FGR
severity, by employing simple machine learning models to predict FGR diagnosis
(100\% accuracy in test data, n=5), GA at delivery, time from MRI scan to
delivery, and baby weight. Moreover, we explored the use of deep learning to
regress the latter three variables. Image texture analysis of the fetal organs
demonstrated prominent textural variations in the placental perfusion fractions
maps between the groups (p0.0009), and spatial differences in the incoherent
fetal capillary blood motion in the liver (p0.009). This research serves as
a proof-of-concept, investigating the effect of FGR on fetal organs
2017 Research & Innovation Day Program
A one day showcase of applied research, social innovation, scholarship projects and activities.https://first.fanshawec.ca/cri_cripublications/1004/thumbnail.jp
3D black blood MRI atlases of congenital aortic arch anomalies and the normal fetal heart:application to automated multi-label segmentation
3D black blood cardiovascular magnetic resonance atlases of congenital aortic arch anomalies and the normal fetal heart:application to automated multi-label segmentation
BACKGROUND: Image-domain motion correction of black-blood contrast T2-weighted fetal cardiovascular magnetic resonance imaging (CMR) using slice-to-volume registration (SVR) provides high-resolution three-dimensional (3D) images of the fetal heart providing excellent 3D visualisation of vascular anomalies [1]. However, 3D segmentation of these datasets, important for both clinical reporting and the application of advanced analysis techniques is currently a time-consuming process requiring manual input with potential for inter-user variability. METHODS: In this work, we present novel 3D fetal CMR population-averaged atlases of normal and abnormal fetal cardiovascular anatomy. The atlases are created using motion-corrected 3D reconstructed volumes of 86 third trimester fetuses (gestational age range 29-34 weeks) including: 28 healthy controls, 20 cases with postnatally confirmed neonatal coarctation of the aorta (CoA) and 38 vascular rings (21 right aortic arch (RAA), 17 double aortic arch (DAA)). We used only high image quality datasets with isolated anomalies and without any other deviations in the cardiovascular anatomy.In addition, we implemented and evaluated atlas-guided registration and deep learning (UNETR) methods for automated 3D multi-label segmentation of fetal cardiac vessels. We used images from CoA, RAA and DAA cohorts including: 42 cases for training (14 from each cohort), 3 for validation and 6 for testing. In addition, the potential limitations of the network were investigated on unseen datasets including 3 early gestational age (22 weeks) and 3 low SNR cases. RESULTS: We created four atlases representing the average anatomy of the normal fetal heart, postnatally confirmed neonatal CoA, RAA and DAA. Visual inspection was undertaken to verify expected anatomy per subgroup. The results of the multi-label cardiac vessel UNETR segmentation showed 100[Formula: see text] per-vessel detection rate for both normal and abnormal aortic arch anatomy. CONCLUSIONS: This work introduces the first set of 3D black-blood T2-weighted CMR atlases of normal and abnormal fetal cardiovascular anatomy including detailed segmentation of the major cardiovascular structures. Additionally, we demonstrated the general feasibility of using deep learning for multi-label vessel segmentation of 3D fetal CMR images. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12968-022-00902-z