4,814 research outputs found

    Updating Data Semantics

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    This paper has three main goals. First, to motivate a puzzle about how ignorance-expressing terms like maybe and if interact: they iterate, and when they do they exhibit scopelessness. Second, to argue that there is an ambiguity in our theoretical toolbox, and that exposing that opens the door to a solution to the puzzle. And third, to explore the reach of that solution. Along the way, the paper highlights a number of pleasing properties of two elegant semantic theories, explores some meta-theoretic properties of dynamic notions of meaning, dips its toe into some hazardous waters, and offers characterization theorems for the space of meanings an indicative conditional can have

    Epistemic Conditions and Social Preferences in Trust Games

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    It is well-known that subjects in bilateral bargaining experiments often exhibit choice behavior suggesting there are strong reciprocators in the population. But it is controversial whether explaining this data requires a social preference model that invokes genuine strong reciprocity or whether some social preference model built on other-regarding preferences as a surrogate can explain it. Since the data precedes theory here, all the social preference models agree on most of it — making direct tests more difficult. We report results from a laboratory experiment using a novel method for testing between the classes of social preference models in the trust game that manipulates the distribution of payoff information in the game. We find evidence supporting the strong reciprocity hypothesis.social preferences, trust game, reciprocity, strong reciprocators

    Peripheral vs. Central Sex Steroid Hormones in Experimental Parkinson’s Disease

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    The nigrostriatal dopaminergic (NSDA) pathway degenerates in Parkinson’s disease (PD), which occurs with approximately twice the incidence in men than women. Studies of the influence of systemic estrogens in females suggest sex hormones contribute to these differences. In this review we analyze the evidence revealing great complexity in the response of the healthy and injured NSDA system to hormonal influences, and emphasize the importance of centrally generated estrogens. At physiological levels, circulating estrogen (in females) or estrogen precursors (testosterone in males, aromatized to estrogen centrally) have negligible effects on dopaminergic neuron survival in experimental PD, but can modify striatal dopamine levels via actions on the activity or adaptive responses of surviving cells. However, these effects are sexually dimorphic. In females, estradiol promotes adaptive responses in the partially injured NSDA pathway, preserving striatal dopamine, whereas in males gonadal steroids and exogenous estradiol have a negligible or even suppressive effect, effectively exacerbating dopamine loss. On balance, the different effects of gonadal factors in males and females contribute to sex differences in experimental PD. Fundamental sex differences in brain organization, including the sexually dimorphic networks regulating NSDA activity are likely to underpin these responses. In contrast, estrogen generated locally appears to preserve striatal dopamine in both sexes. The available data therefore highlight the need to understand the biological basis of sex-specific responses of the NSDA system to peripheral hormones, so as to realize the potential for sex-specific, hormone-based therapies in PD. Furthermore, they suggest that targeting central steroid generation could be equally effective in preserving striatal dopamine in both sexes. Clarification of the relative roles of peripheral and central sex steroid hormones is thus an important challenge for future studies

    Fifteen and counting : Vermont research 1974-1989 (and beyond)

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    Occasional paper (University of Vermont. Center for Research on Vermont

    Universality in the Gravitational Stretching of Clocks, Waves and Quantum States

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    There are discernible and fundamental differences between clocks, waves and physical states in classical physics. These fundamental concepts find a common expression in the context of quantum physics in gravitational fields; matter and light waves, quantum states and oscillator clocks become quantum synonymous through the Planck-Einstein-de Broglie relations and the equivalence principle. With this insight, gravitational effects on quantum systems can be simply and accurately analyzed. Apart from providing a transparent framework for conceptual and quantitative thinking on matter waves and quantum states in a gravitational field, we address and resolve with clarity the recent controversial discussions on the important issue of the relation and the crucial difference between gravimetery using atom interferometers and the measurement of gravitational time dilation.Comment: Gravity Research Foundation honorable mention, 201
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