Functional genomics of the pregnant uterus: from expectations to reality, a compilation of studies in the myometrium-1

<p><b>Copyright information:</b></p><p>Taken from "Functional genomics of the pregnant uterus: from expectations to reality, a compilation of studies in the myometrium"</p><p>http://www.biomedcentral.com/1471-2393/7/S1/S4</p><p>BMC Pregnancy and Childbirth 2007;7(Suppl 1):S4-S4.</p><p>Published online 1 Jun 2007</p><p>PMCID:PMC1892061.</p><p></p>a two fold or more factor. White boxes denote insufficiently documented links in context. Comparison between Preterm not in labor and Term not in labor or Term in labor. Pathways are shown with their known links to cytokine, growth factors (GF) and G-protein coupled membrane receptors (GPCR). CAMs, cell adhesion molecules. ECM, extra-cellular matrix)

Functional genomics of the pregnant uterus: from expectations to reality, a compilation of studies in the myometrium-0

<p><b>Copyright information:</b></p><p>Taken from "Functional genomics of the pregnant uterus: from expectations to reality, a compilation of studies in the myometrium"</p><p>http://www.biomedcentral.com/1471-2393/7/S1/S4</p><p>BMC Pregnancy and Childbirth 2007;7(Suppl 1):S4-S4.</p><p>Published online 1 Jun 2007</p><p>PMCID:PMC1892061.</p><p></p>s OR microarray) AND uterus (closed grey circles); (functional genomics OR microarray) AND uterus AND pregnant (open white circles); (functional genomics OR microarray) AND uterus AND myometrium (open white diamonds). On the graph, the number of papers is divided by 100 for the total papers on functional genomics OR microarray (black squares)

Complete histological evaluation of the cervix.

<p>Mucous plug (m), epithelial cells (e), mucosal chorion (c), submucosa (s).</p

SHG/2PF images.

<p>(a-c) control and (d-f) treated samples imaged in two photon microscopy, in the mucosal chorion/submucosa region of fixed slices. (a,d) Composite 2PF(grey)/SHG(green) image (scale bar: 100 <i>μ</i>m). Separated SHG/2PF are shown in (b,c) and (e,f) inside the mucosal chorion (scale bar: 100 <i>μ</i>m).</p

Structures identified by histological evaluation in the cervical tissue.

<p>Mucous plug (m), epithelial cells (e), mucosal chorion (c), submucosa (s). Collagen fibres: red arrow; Macrophages: arrowhead; lymphocytes: solid arrow; fibroblasts: empty arrow.</p

Characteristics of the study population.

<p>Characteristics of the study population.</p

SHG zoomed images.

<p>Typical SHG zoomed images in the mucosal chorion region of (a) control and (b) treated samples, and in the submucosa region of (c) control and (d) treated sample. Scale bars: 20 <i>μ</i>m. SHG ROI images are intentionally contrasted in order to enhance the visibility of the morphological differences between the control and treated samples. Corresponding 2D FT images, thresholded at 80% of their maximal intensity, are shown in (e-h) for (e) control/mucosal chorion (maximum intensity = 971 counts, R = 0.28), (f) treated/mucosal chorion (maximum intensity = 737 counts, R = 0.39), (g) control/submucosa (maximum intensity = 581 counts, R = 0.42), (h) treated/ submucosa (maximum intensity = 412 counts, R = 0.43). Average values and standard deviations (plotted error bars) are given for 5-10 regions, measured from two different animals (* = significant at 5% level; ** = significant at 1% level).</p

PGE2 and its metabolites in sheep serum just before the first elastographic exam (sample 1) and at the end of the experiment just before euthanasia (sample 2), assayed via its metabolite PGEM with Cayman’s Prostaglandin E Metabolite EIA Kit (Item No. 514531, Cayman chemical).

<p>PGE2 and its metabolites in sheep serum just before the first elastographic exam (sample 1) and at the end of the experiment just before euthanasia (sample 2), assayed via its metabolite PGEM with Cayman’s Prostaglandin E Metabolite EIA Kit (Item No. 514531, Cayman chemical).</p

Example of a ROI (white circle) of 5 mm diameter positioned in elastographic image following only anatomical criteria on the conventional B-mode image.

<p>Stiffness value estimated inside the ROI: 10.2 kPa ± 0.5 kPa [9.6—11.9] kPa.</p

Measurement of the external diameter of the cervical mucosa (green line).

<p>Measurement of the external diameter of the cervical mucosa (green line).</p