EPR entanglement strategies in two-well BEC

Criteria suitable for measuring entanglement between two different potential wells in a Bose- Einstein condensation (BEC) are evaluated. We show how to generate the required entanglement, utilizing either an adiabatic two-mode or dynamic four-mode interaction strategy, with techniques that take advantage of s-wave scattering interactions to provide the nonlinear coupling. The dynamic entanglement method results in an entanglement signature with spatially separated detectors, as in the Einstein-Podolsky-Rosen (EPR) paradox.Comment: 4 pages, 4 figure

Unique Mass Texture for Quarks and Leptons

Texture specific quark mass matrices which are hermitian and hierarchical are examined in detail . In the case of texture 6 zeros matrices, out of sixteen possibilities examined by us, none is able to fit the low energy data (LED), for example, $V_{us} = 0.2196 \pm 0.0023$, $V_{cb} = 0.0395 \pm 0.0017$, $\frac{V_{ub}}{V_{cb}} = 0.08 \pm 0.02$, $V_{td}$ lies in the range $0.004 - 0.013$ (PDG). Similarly none of the 32 texture 5 zeros mass matrices considered is able to reproduce LED. In particular, the latest data from LEP regarding $|V_{ub}|/|V_{cb}|(=0.093\pm0.016)$ rules out all of them. In the texture 4 zeros case, we find that there is a unique texture structure for $U$ and $D$ mass matrices which is able to fit the data.Comment: 12 pages, LaTeX,some changes in the references,minor changes in the text,to appear in Phys Rev D(Rapid communications

Utility of novel viral and immune markers in predicting HBV treatment endpoints: A systematic review of treatment discontinuation studies.

BACKGROUND & AIMS: Antivirals represent the mainstay of chronic hepatitis B treatment given their efficacy and tolerability, but rates of functional cure remain low during long-term therapy. Treatment discontinuation has emerged as a strategy to maintain partial cure and achieve functional cure in select patient groups. We aimed to evaluate how data from treatment discontinuation studies exploring novel viral and/or immune markers could be applied to the functional cure program. METHODS: Treatment discontinuation studies evaluating novel viral and/or immune markers were identified by a systematic search of the PubMed database through to October 30, 2022. Data extraction focused on information regarding novel markers, including identified cut-off levels, timing of measurement, and associated effect on study outcomes of virological relapse, clinical relapse, and HBsAg seroclearance. RESULTS: From a search of 4,492 citations, 33 studies comprising a minimum of 2,986 unique patients met the inclusion criteria. Novel viral markers, HBcrAg and HBV RNA, were demonstrated across most studies to be helpful in predicting off-therapy partial cure, with emerging evidence to support a link with functional cure. From novel immune marker studies, we observed that treatment discontinuation has the potential to trigger immune restoration, which may be associated with a transient virological relapse. To this end, these studies support the combination of virus-directing agents with immunomodulator therapies to induce two key steps underlying functional cure: viral antigen load reduction and restoration of the host immune response. CONCLUSIONS: Patients with a favourable profile of novel viral and immune markers stand to benefit from a trial of antiviral treatment discontinuation alongside novel virus-directing agents with the aim of achieving functional cure without excessive risk of severe clinical relapse. IMPACT AND IMPLICATIONS: Select patients with chronic hepatitis B undergoing nucleoside analogue therapy may benefit from a trial of treatment discontinuation, aiming to maintain partial cure and/or achieve functional cure. We propose a profile of novel viral and immune markers to identify patients who are likely to achieve these goals without excessive risk of hepatic decompensation. Furthermore, treatment discontinuation may also be considered as a therapeutic strategy to trigger immune restoration, which may increase the chance of functional cure when used in conjunction with novel virus-directing agents

Ion-Acoustic Solitons in Bi-Ion Dusty Plasma

The propagation of ion-acoustic solitons in a warm dusty plasma containing two ion species is investigated theoretically. Using an approach based on the Korteveg-de-Vries equation, it is shown that the critical value of the negative ion density that separates the domains of existence of compressi- on and rarefaction solitons depends continuously on the dust density. A modified Korteveg-de Vries equation for the critical density is derived in the higher order of the expansion in the small parameter. It is found that the nonlinear coefficient of this equation is positive for any values of the dust density and the masses of positive and negative ions. For the case where the negative ion density is close to its critical value, a soliton solution is found that takes into account both the quadratic and cubic nonlinearities. The propagation of a solitary wave of arbitrary amplitude is investigated by the quasi-potential method. It is shown that the range of the dust densities around the critical value within which solitary waves with positive and negative potentials can exist simultaneously is relatively wide.Comment: 17 pages, 5 figure

Texture of Yukawa coupling matrices in general two-Higgs-doublet model

We discuss possible parallel textures of the Yukawa coupling matrices in the generaltwo-Higgs-doublet model (2HDM). In those textures the flavor changing neutral currentsare naturally suppressed. Motivated by a phenomenologically successful texturewith four texture zeros in the standard model, we propose a predictive ansatz for the Yukawa coupling matrices with the same texture in the general 2HDM. Compared with the six texture-zero based ansatz proposed by Cheng and Sher, it is in a better agreement with the data of quark mixings and CP violation. The four texture-zero based ansatz predicts a different hierarchy in the Yukawa coupling matrix elements. As a consequence, in the lepton sector, the related Yukawa couplings are less constrained by the experimental upper bound of $\mu\to e\gamma$, which allows significantly larger predictions for other processes. The contributions from neutral scalar interactions to the lepton number violation decay modes $\ell\to \ell_{1}\ell_{2}\ell_{3}$ are calculated in both ansatz. It is shown that the predictions from the four texture-zero based ansatz could be two order of magnitude greater than that from the six texture-zero based one. The branching ratio of $\mu\to 3e$ and $\tau\to 3\mu$ can reach $7.5 \times 10^{-17}$ and 1.3\tiems 10^{-10} respectively. The predicted ratio of $Br(\mu\to 3e)/Br(\tau\to 3e)$ is also larger and almost parameter independent. Those differences make the two ansatz to be easily distinguished by the future experiments.Comment: 12 pages, 2 figure

Measurement of the analyzing power in pp elastic scattering in the peak CNI region at RHIC

We report the first measurements of the A_N absolute value and shape in the -t range from 0.0015 to 0.010GeV/c^2 with a precision better than 0.005 for each A_N data point using a polarized atomic hydrogen gas jet target and the 100 GeV RHIC proton beam.Comment: 4 pages, 5 figure

Uniform electron gases

We show that the traditional concept of the uniform electron gas (UEG) --- a homogeneous system of finite density, consisting of an infinite number of electrons in an infinite volume --- is inadequate to model the UEGs that arise in finite systems. We argue that, in general, a UEG is characterized by at least two parameters, \textit{viz.} the usual one-electron density parameter $\rho$ and a new two-electron parameter $\eta$. We outline a systematic strategy to determine a new density functional $E(\rho,\eta)$ across the spectrum of possible $\rho$ and $\eta$ values.Comment: 8 pages, 2 figures, 5 table