The community of salvation in the theology of St. Luke

This thesis is an attempt to understand Luke's own thought on the community who enjoyed the salvation found by faith in Jesus Christ. Recent Lukan studies have shown that our estimation of Luke’s eschatology determines our estimation of the nature of the salvation proclaimed and of those, who considered collectively, embrace it. In both the Gospel and Acts kike enhances the eschatological significance of the present. In the Gospel, the Kingdom of God is present in a dynamic way through the ministry of Jesus and His disciples. In Acts the Holy Spirit inaugurates the new age and enables Luke to continue to speak of Christ as the present Lord. Thus salvation, a basic motif, is understood by Luke as the gift of "the last day" in the present. In the Gospel, salvation is found in fellowship with Jesus, in Acts, in fellowship with the Spirit. In both books Jesus' disciples are to be recognized as the historical eschatological community of salvation. The second half of the study concentrates attention on the titles Luke gives to this community. In the Gospel the only title he develops is "the disciples." His development of this title shows mature thought and suggests wide usage in the early Church. Not only is this term a "church idea," it is also used to bring before our attention what it means to be a Christian in the age after Easter. In Acts many titles are found, most of which tell us something about the community of salvation. Again, "the disciples" is the most important and most developed one. The word εκκλησίɤ on the other hand, is not developed. It only refers to a specific group of people who actually assemble together: it is not used in the catholic sense. Acts 9%31 is interpreted as the individual members of the Church of Jerusalem dispersed throughout Judea Samaria and Galilee, and Acts 20:28 as revealing Pauline theology. The resultant picture suggests that Luke's eschatology and views on salvation are theologically mature and very similar to those of St.Paul. His theology of the community of salvation, on the other hand, is not theologically developed. "The Church" is not an ontological reality; it is not the body of Christ. Individual relationship to Christ retains a primacy in Lukan theology. -Those who are saved are "true Israel," not "new Israel," -"a third race.

The community of salvation in the theology of St. Luke

This thesis is an attempt to understand Luke's own thought on the community who enjoyed the salvation found by faith in Jesus Christ. Recent Lukan studies have shown that our estimation of Luke’s eschatology determines our estimation of the nature of the salvation proclaimed and of those, who considered collectively, embrace it. In both the Gospel and Acts kike enhances the eschatological significance of the present. In the Gospel, the Kingdom of God is present in a dynamic way through the ministry of Jesus and His disciples. In Acts the Holy Spirit inaugurates the new age and enables Luke to continue to speak of Christ as the present Lord. Thus salvation, a basic motif, is understood by Luke as the gift of "the last day" in the present. In the Gospel, salvation is found in fellowship with Jesus, in Acts, in fellowship with the Spirit. In both books Jesus' disciples are to be recognized as the historical eschatological community of salvation. The second half of the study concentrates attention on the titles Luke gives to this community. In the Gospel the only title he develops is "the disciples." His development of this title shows mature thought and suggests wide usage in the early Church. Not only is this term a "church idea," it is also used to bring before our attention what it means to be a Christian in the age after Easter. In Acts many titles are found, most of which tell us something about the community of salvation. Again, "the disciples" is the most important and most developed one. The word εκκλησίɤ on the other hand, is not developed. It only refers to a specific group of people who actually assemble together: it is not used in the catholic sense. Acts 9%31 is interpreted as the individual members of the Church of Jerusalem dispersed throughout Judea Samaria and Galilee, and Acts 20:28 as revealing Pauline theology. The resultant picture suggests that Luke's eschatology and views on salvation are theologically mature and very similar to those of St.Paul. His theology of the community of salvation, on the other hand, is not theologically developed. "The Church" is not an ontological reality; it is not the body of Christ. Individual relationship to Christ retains a primacy in Lukan theology. -Those who are saved are "true Israel," not "new Israel," -"a third race.

Shadow Hybridity and the Institutional Logic of professional sport : Perpetuating a sporting business in times of rapid social and economic change

Purpose: Existing studies of the finance of English Association Football (soccer) have tended to focus on the sport’s early years, or on the post-1992 Premiership era. We examine a case from the turbulent 1980s charting the struggle for economic survival of one club in a rapidly changing financial, economic, political, and demographic landscape. Design/methodology/approach: We investigate the financial difficulties of a sport business, Middlesbrough Football and Athletic Company Limited (MFAC), examining the broader economic context, drawing on unseen archival sources dating from the 1980s to analyse the relationship between club, local and national government, and the regional economy. Findings: We examine not only the financial management of the football club but also analyse the interventionist role of the local authority in supporting the club which had symbolic value for the local community. Practical implications: This paper is relevant to policy makers interested in the provision of local sports facilities and the links between elite sport and participation. Originality/value: We show that professional sports clubs are driven by a different institutional logic to state organisations and our findings enable us to define these differences, thereby refining Thornton et al’s (2012) typology of institutional orders. Furthermore our case study highlights practices involving informal partnership between state and sport that we label shadow hybridity

Evidence for Structural Variants of a- and b-Type Peptide Fragment Ions Using Combined Ion Mobility/Mass Spectrometry

Tandem mass spectrometry (MS/MS) of peptides plays a key role in the field of proteomics, and an understanding of the fragmentation mechanisms involved is vital for data interpretation. Not all the fragment ions observed by low-energy collision-induced dissociation of protonated peptides are readily explained by the generally accepted structures for a- and b-ions. The possibility of a macrocyclic structure for b-type ions has been recently proposed. In this study, we have undertaken investigations of linear protonated YAGFL-NH2, N-acetylated-YAGFL-NH2, and cyclo-(YAGFL) peptides and their fragments using a combination of ion mobility (IM) separation and mass spectrometry. The use of IM in this work both gives insight into relative structural forms of the ion species and crucial separation of isobaric species. Our study provides compelling evidence for the formation of a stable macrocyclic structure for the b5 ion generated by fragmentation of protonated linear YAGFL-NH2. Additionally we demonstrate that the a4 ion fragment of protonated YAGFL-NH2 has at least two structures; one of which is attributable to a macrocyclic structure on the basis of its subsequent fragmentation. More generally, this work emphasizes the value of combined IM-MS/MS in probing the detailed fragmentation mechanisms of peptide ions, and illustrates the use of combined ion mobility/collisional activation/mass spectrometry analysis in achieving an effective enhancement of the resolution of the mobility separator

Tightly Coupled Formation Flight of Swarms to Support Extended Range and Deception

Seed Research Program 2023. A Quad, describing CRUSER Seed Research Program funded research.CRUSER Funded ResearchFY23 Funded Research ProposalConsortium for Robotics and Unmanned Systems Education and Research (CRUSER

Novel pyrrolobenzodiazepine benzofused hybrid molecules inhibit NF-κB activity and synergise with bortezomib and ibrutinib in hematological cancers

Chronic lymphocytic leukemia (CLL) and multiple myeloma (MM) are incurable hematological malignancies that are pathologically linked with aberrant NF-κB activation. In this study, we identified a group of novel C8-linked benzofused Pyrrolo[2,1-c][1,4]benzodiazepines (PBD) monomeric hybrids capable of sequence-selective inhibition of NF-κB with low nanomolar LD50 values in CLL (n=46) and MM cell lines (n=5). The lead compound, DC-1-192, significantly inhibited NF-κB DNA binding after just 4h exposure and demonstrating inhibitory effects on both canonical and non-canonical NF-κB subunits. In primary CLL cells, sensitivity to DC-1-192 was inversely correlated with RelA subunit expression (r2=0.2) and samples with BIRC3 or NOTCH1 mutations showed increased sensitivity (P=0.001). RNA-sequencing and gene set enrichment analysis confirmed the over-representation of NF-κB regulated genes in the down-regulated gene list. Furthermore, In vivo efficacy studies in NOD/SCID mice, using a systemic RPMI 8226 human multiple myeloma xenograft model, showed that DC-1-192 significantly prolonged survival (P=0.017). In addition, DC1-192 showed synergy with bortezomib and ibrutinib; synergy with ibrutinib was enhanced when CLL cells were co-cultured on CD40L-expressing fibroblasts in order to mimic the cytoprotective lymph node microenvironment (P = 0.01). Given that NF-κB plays a role in both bortezomib and ibrutinib resistance mechanisms, these data provide a strong rationale for the use of DC-1-192 in the treatment of NF-κB-driven cancers, particularly in the context of relapsed/refractory disease

Contemporary Analysis of Malignancies in Women of Child-Bearing Age: An NSQIP Analysis

Background: Recent evidence suggests that cancer incidence among pregnant women is increasing. The pattern of malignancies in pregnant women and how these compare to their nonpregnant counterparts has not been explored. Here we describe the differences in the proportion of resected malignancies in this population. Methods: The American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) database was used to identify women aged 18-49 who underwent an operation for malignancy from 2007-2012. Age-adjusted distribution of specific surgical interventions for malignancy based on ICD-9 codes were compared among pregnant and non-pregnant women using logistic regression analysis. Results: 42,732 subjects with malignancies surgically treated during child-bearing age were identified. 0.33% (n=143) were pregnant. The most common tumors requiring resection were breast (51%), thyroid (17%), and colorectal (9%). The distribution for most cancers was similar between groups. The age-adjusted proportion was significantly increased in breast, major salivary gland and oropharyngeal malignancies (p\u3c0.05). The proportion of resected colorectal cancers was significantly lower in pregnant women (p\u3c0.05; Table 1). Conclusion: This study serves as the first comprehensive and contemporary overview of malignancies resected in women of childbearing age. This study demonstrates that the proportion of resections among pregnant women was significantly greater in breast, major salivary gland and oropharyngeal cancers and lower for colorectal cancers. While these data might represent true differences in cancer incidence, further work is necessary to demonstrate if these are true differences in incidence versus differences in detection and treatment of the pregnant patient

Remote sensing of fish-processing in the Sundarbans Reserve Forest, Bangladesh: an insight into the modern slavery-environment nexus in the coastal fringe

© 2020, The Author(s). Land-based fish-processing activities in coastal fringe areas and their social-ecological impacts have often been overlooked by marine scientists and antislavery groups. Using remote sensing methods, the location and impacts of fish-processing activities were assessed within a case study of Bangladesh’s Sundarbans mangrove forests. Ten fish-processing camps were identified, with some occurring in locations where human activity is banned. Environmental degradation included the removal of mangroves, erosion, and the destruction of protected areas. Previous studies have identified cases of labour exploitation and modern slavery occurring within the Sundarbans, and remote sensing was used to triangulate these claims by providing spatial and temporal analysis to increase the understanding of the operational trends at these locations. These findings were linked to the cyclical relationship between modern slavery and environmental degradation, whereby environmental damage is both a driver and result of workers subjected to modern slavery. Remote sensing can be used as an additional methodological tool to support the achievement of the Sustainable Development Goals (SDGs) and provide evidence to support the promotion of the “freedom dividend” which would have far-reaching economic, social, cultural, and environmental benefits. Satellite remote sensing is likely to play an important role going forward for understanding these issues but should be augmented with ground-based data collection methods

Identification of Native Defects (Vacancies and Antisites) in CdSiP2 Crystals

Electron paramagnetic resonance (EPR) is used to identify four native defects in single crystals of CdSiP2. This nonlinear optical material is used in optical parametric oscillators to generate tunable output in the mid-infrared. The performance of these frequency-conversion devices is limited when infrared absorption bands associated with native defects overlap a pump wavelength. Cadmium, silicon, and phosphorus vacancies and also silicon-on-cadmium antisites are present in the as-grown undoped CdSiP2 crystals. Using near-band-edge 632.8 nm light from a He-Ne laser, a paramagnetic charge state, and thus an EPR spectrum, is formed at liquid-helium temperatures for three of the four defects. The EPR spectrum from the singly ionized silicon vacancy (V-Si) is present without light and has five hyperfine lines due to equal interactions with the four neighboring 31P nuclei. In contrast, the photoinduced EPR spectrum from the singly ionized cadmium vacancy (V-Cd) has a three-line hyperfine pattern due to equal interactions with only two of its four neighboring 31P nuclei. The light-induced spectrum from the singly ionized silicon-on-cadmium antisite (Si+Cd) also has a three-line hyperfine pattern, thus indicating that the unpaired spin interacts primarily with only two 31P neighbors. For the neutral phosphorus vacancy (V0P), the unpaired spin is primarily localized on the nearest-neighbor silicon ions and the photoinduced EPR spectrum has no resolved 31P hyperfine interactions. The silicon and cadmium vacancies are acceptors, and the silicon-on-cadmium antisite and the phosphorus vacancy are donors