Reabilitação do parque olímpico de Berlim: um acesso para todos

O Prémio Schindler é um concurso de arquitectura que desafia jovens arquitectos a recriarem espaços que têm como filosofia de design “Acesso para todos”. O concurso refere-se a projectos urbanos que se caracterizam por melhorar o acesso e mobilidade global para todos os moradores da cidade ou do espaço urbano a que se refere, independentemente da sua idade, estado ou capacidades físicas. Para chegar a este fim, compete-me pensar para além da forma, luz e materiais e me concentrar nas necessidades das pessoas. A proposta deste ano refere-se a reabilitação do parque junto ao estádio olímpico de Berlim, lugar que foi outrora um local de grande propaganda Nazi durante os jogos olímpicos de 1936 e por assim caracterizado pela arquitectura daquele regime. A reabilitação refere-se a todas as infra-estruturas já existentes assim como a construção de um novo complexo desportivo que acolherá uma pista de hóquei no gelo e uma área reservada para a concepção de residências.The Schindler Award is an architectural competition that challenges young architects to recreate spaces that have a philosophy of design "Access for all". This contract refers to urban projects that are characterized by improved global access and mobility for all residents of the city or urban area referred to, regardless of their age, or physical abilities. The objective is to think beyond the form, light and materials and to focus on the needs of people. The purpose of this year is the rehabilitation of the park near the Olympic Stadium in Berlin, a place that it was once a place of great Nazi propaganda during the Olympic Games in 1936 and so marked by the Nazi architecture. Rehabilitation refers of the all infrastruc ture already existing and the construction of a new sports complex that will host a ice hockey field and a reserved area for the design of homes

NEOTROPICAL XENARTHRANS: a data set of occurrence of xenarthran species in the Neotropics

Xenarthrans—anteaters, sloths, and armadillos—have essential functions for ecosystem maintenance, such as insect control and nutrient cycling, playing key roles as ecosystem engineers. Because of habitat loss and fragmentation, hunting pressure, and conflicts with domestic dogs, these species have been threatened locally, regionally, or even across their full distribution ranges. The Neotropics harbor 21 species of armadillos, 10 anteaters, and 6 sloths. Our data set includes the families Chlamyphoridae (13), Dasypodidae (7), Myrmecophagidae (3), Bradypodidae (4), and Megalonychidae (2). We have no occurrence data on Dasypus pilosus (Dasypodidae). Regarding Cyclopedidae, until recently, only one species was recognized, but new genetic studies have revealed that the group is represented by seven species. In this data paper, we compiled a total of 42,528 records of 31 species, represented by occurrence and quantitative data, totaling 24,847 unique georeferenced records. The geographic range is from the southern United States, Mexico, and Caribbean countries at the northern portion of the Neotropics, to the austral distribution in Argentina, Paraguay, Chile, and Uruguay. Regarding anteaters, Myrmecophaga tridactyla has the most records (n = 5,941), and Cyclopes sp. have the fewest (n = 240). The armadillo species with the most data is Dasypus novemcinctus (n = 11,588), and the fewest data are recorded for Calyptophractus retusus (n = 33). With regard to sloth species, Bradypus variegatus has the most records (n = 962), and Bradypus pygmaeus has the fewest (n = 12). Our main objective with Neotropical Xenarthrans is to make occurrence and quantitative data available to facilitate more ecological research, particularly if we integrate the xenarthran data with other data sets of Neotropical Series that will become available very soon (i.e., Neotropical Carnivores, Neotropical Invasive Mammals, and Neotropical Hunters and Dogs). Therefore, studies on trophic cascades, hunting pressure, habitat loss, fragmentation effects, species invasion, and climate change effects will be possible with the Neotropical Xenarthrans data set. Please cite this data paper when using its data in publications. We also request that researchers and teachers inform us of how they are using these data

Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19

BackgroundWe previously reported that impaired type I IFN activity, due to inborn errors of TLR3- and TLR7-dependent type I interferon (IFN) immunity or to autoantibodies against type I IFN, account for 15-20% of cases of life-threatening COVID-19 in unvaccinated patients. Therefore, the determinants of life-threatening COVID-19 remain to be identified in similar to 80% of cases.MethodsWe report here a genome-wide rare variant burden association analysis in 3269 unvaccinated patients with life-threatening COVID-19, and 1373 unvaccinated SARS-CoV-2-infected individuals without pneumonia. Among the 928 patients tested for autoantibodies against type I IFN, a quarter (234) were positive and were excluded.ResultsNo gene reached genome-wide significance. Under a recessive model, the most significant gene with at-risk variants was TLR7, with an OR of 27.68 (95%CI 1.5-528.7, P=1.1x10(-4)) for biochemically loss-of-function (bLOF) variants. We replicated the enrichment in rare predicted LOF (pLOF) variants at 13 influenza susceptibility loci involved in TLR3-dependent type I IFN immunity (OR=3.70[95%CI 1.3-8.2], P=2.1x10(-4)). This enrichment was further strengthened by (1) adding the recently reported TYK2 and TLR7 COVID-19 loci, particularly under a recessive model (OR=19.65[95%CI 2.1-2635.4], P=3.4x10(-3)), and (2) considering as pLOF branchpoint variants with potentially strong impacts on splicing among the 15 loci (OR=4.40[9%CI 2.3-8.4], P=7.7x10(-8)). Finally, the patients with pLOF/bLOF variants at these 15 loci were significantly younger (mean age [SD]=43.3 [20.3] years) than the other patients (56.0 [17.3] years; P=1.68x10(-5)).ConclusionsRare variants of TLR3- and TLR7-dependent type I IFN immunity genes can underlie life-threatening COVID-19, particularly with recessive inheritance, in patients under 60 years old

Correction: Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19

International audienc

Measurements of the suppression and correlations of dijets in Pb+Pb collisions at sNN\sqrt {s_{NN}} = TeV

Studies of the correlations of the two highest transverse momentum (leading) jets in individual Pb+Pb collision events can provide information about the mechanism of jet quenching by the hot and dense matter created in such collisions. In Pb+Pb and $pp$ collisions at $\sqrt {s_{NN}}$ = 5.02 TeV, measurements of the leading dijet transverse momentum $(p_T)$ correlations are presented. Additionally, measurements in Pb+Pb collisions of the dijet pair nuclear modification factors projected along leading and subleading jet $p_T$ are made. The measurements are performed using the ATLAS detector at the LHC with 260 pb$^{−1}$ of $pp$ data collected in 2017 and 2.2 nb$^{−1}$ of Pb+Pb data collected in 2015 and 2018. An unfolding procedure is applied to the two-dimensional leading and subleading jet $p_T$ distributions to account for experimental effects in the measurement of both jets. Results are provided for dijets with leading jet $p_T$ greater than 100 $GeV$. Measurements of the dijet-yield-normalized $x_J$ distributions in Pb+Pb collisions show an increased fraction of imbalanced jets compared to $pp$ collisions; these measurements are in agreement with previous measurements of the same quantity at 2.76 TeV in the overlapping kinematic range. Measurements of the absolutely normalized dijet rate in Pb+Pb and pp collisions are also presented, and show that balanced dijets are significantly more suppressed than imbalanced dijets in Pb+Pb collisions. It is observed in the measurements of the pair nuclear modification factors that the subleading jets are significantly suppressed relative to leading jets with $p_T$ between 100 and 316 $GeV$ for all centralities in Pb+Pb collisions

Observation of WWW Production in pp Collisions at √s = 13 TeV with the ATLAS Detector

This Letter reports the observation of W W W production and a measurement of its cross section using 139     fb − 1 of proton-proton collision data recorded at a center-of-mass energy of 13 TeV by the ATLAS detector at the Large Hadron Collider. Events with two same-sign leptons (electrons or muons) and at least two jets, as well as events with three charged leptons, are selected. A multivariate technique is then used to discriminate between signal and background events. Events from W W W production are observed with a significance of 8.0 standard deviations, where the expectation is 5.4 standard deviations. The inclusive W W W production cross section is measured to be 820 ± 100   ( stat ) ± 80   ( syst )     fb , approximately 2.6 standard deviations from the predicted cross section of 511 ± 18     fb calculated at next-to-leading-order QCD and leading-order electroweak accuracy