Synopsis of Biological Safety and Security Arrangements

PASCC ReportThis Synopsis provides summaries of key international treaties, agreements, instruments, guidelines, multilateral engagement mechanisms, and information resources intended to guide each individual nation’s approach to biosafety in research, clinical, and industrial laboratories. It summarizes the benefits and limitations of each in promoting biosafety, and their individual contributions towards minimizing the global risk and consequences of laboratory accidents. Though the compilation of these arrangements, we have determined that there is an extensive array of existent governmental mechanisms related to biosafety. However, this work also exposed a major gap in international biosafety coverage related to the potential for high-consequence accidents: there remains a need for international norms for the biosafety and governance of those pathogens that have increased potential to spark a pandemic.This project was supported by the Naval Postgraduate School Project on Advanced Systems and Concepts for Countering WMD (PASCC) Grant No. N00244-15-1-0028 to provide funding support for research entitled "Improving Security Through International Biosafety Norms.

A Holistic Assessment of the Risks and Benefits of the Synthesis of Horsepox Virus

ABSTRACT The re-creation of horsepox virus, an extinct orthopoxvirus with similarity to smallpox virus, has caused concerns in the biosecurity and biodefense communities that the technical capabilities achieved could advance the re-creation of smallpox virus by nefarious actors. The work is now published. While the authors went through due biosecurity diligence at their research institution and with the proper Canadian federal authorities, now that the experiments have been published, there is an opportunity to discuss the dual use risks and benefits of the research itself, as well as those associated with publication of such research—all of which challenge current policies. Here, an analytical framework is used to assess the risks and benefits of such dual use research, and relevant components of biosecurity policy and the biodefense enterprise (including the acquisition of medical countermeasures) in the United States are discussed. The authors emphasize the need to use such risk/benefit assessments at the onset of research and throughout its development, followed by an assessment for its responsible communication

Singapore - US Strategic Dialogue on Biosecurity

PASCC ReportSingapore is a critical security partner to the US in Southeast Asia. The US and Singapore share long-standing military relations, with American forces making use of Singapore’s Naval Base facilities, contributing to peace and stabilizing efforts throughout the region, offering humanitarian assistance, and acting as a deterrent to potential security threats.1 US-Singaporean security cooperation also extends to bilateral exercises, joint military training activities, and cargo screening efforts. The importance of Singapore to biosecurity in Southeast Asia continues to grow, due to its rapid biotechnology growth, its leadership in biosafety training within the region, its experience in containing the pandemic of severe acute respiratory syndrome (SARS), as well as ongoing preparedness efforts related to new, emerging diseases.This publication results from research supported by the Naval Postgraduate School’s Project on Advanced Systems and Concepts for Countering Weapons of Mass Destruction (PASCC) via Assistance Grant/Agreement No. N00244-14-1-0040 awarded by the NAVSUP Fleet Logistics Center San Diego (NAVSUP FLC San Diego). Project on Advanced Systems and Concepts for Countering Weapons of Mass Destruction, Naval Postgraduate School, Defense Threat Reduction Agenc