Pastoral livelihood pathways transitions in northern Kenya: The process and impact of drought

Abstract Recurrent droughts and long-term changes to climate, social structures, and the economy in the world’s arid and semi-arid lands have impacted pastoralists’ livelihood activities over time, resulting in different livelihood pathways. Some pastoralists continue to follow more traditional strategies of herd accumulation, while others frequently engage in livestock markets and value addition activities, and others still are dropping out of pastoralism. Using data collected over 6 years from 924 households in northern Kenya and applying a generalized structural dynamic multinomial logit model, this study quantitatively determined the dynamic transitions between livelihood categories conditional on drought incidences. From the results, there were considerable and frequent transitions between livelihood pathways within the panel period (2009–2015). Notably, many households that started in the low-cash income, larger herd size category denoted as hanging in, were transitioning to lower cash income with small herds (dropping out). At the same time, there was a great deal of back and forth between the category with low-cash income and small herd size (dropping out) and the category with higher cash income and small herd size (moving out), indicating that moving out was the only way out of poverty. Also, an increase in vegetation index from a drought season where the index was at a 10% level to a good season where the level was 90% decreased the likelihood of households dropping out from a predicted probability of 37.9 to 28.7% and increased the likelihood of moving up and moving out from 22.2 to 25.0% and 22.6 to 34.3%, respectively, unconditionally. The study findings imply that any livelihood interventions aimed at reducing the impact of drought and alleviating poverty among pastoral households should support the transition to market-oriented, relatively successful pathways and also protect households from falling back into the ranks of poverty by dropping out

PENGARUH PERLAKUAN PANAS TERHADAP KABEL PVC

Pada penelitian ini dilakukan analisis kabel polivinil klorida (PVC) yang terkena efek panas dan uji panas pada suhu 70, 90, 110, 120, dan 140 0C. Pemanasan pada spesimen sebanyak 20 buah sebagai simulasi dilakukan selama 2 jam dengan suhu yang telah ditentukan. Pengujian dan analisis dilakukan pada material sebelum dan sesudah perlakuan panas. Hasil uji sifat mekanis menunjukkan bahwa tegangan luluh kabel PVC 65,53 MPa dengan tegangan maksimum 81,93 MPa. Selain itu, pemuluran atau elongasi didapat 29,46% dan modulus elastisitas kabel PVC adalah 298,2 MPa. Untuk melihat perbedaan struktur kabel PVC sebelum dan sesudah pemanasan dilakukan dengan Scanning Electron Microscope (SEM). Hasil foto mikro memperlihatkan bahwa perlakuan panas sampai suhu 140 °C tidak merubah struktur yang terdapat pada selubung PVC dan kabel PVC masih memenuhi standar SPLN dan SNI untuk digunakan kembali sebagai kabel instalasi pada gedung bertingkat

Statistical analysis of factors driving surface ozone variability over continental South Africa

Statistical relationships between surface ozone (O-3) concentration, precursor species and meteorological conditions in continental South Africa were examined from data obtained from measurement stations in north-eastern South Africa. Three multivariate statistical methods were applied in the investigation, i.e. multiple linear regression (MLR), principal component analysis (PCA) and -regression (PCR), and generalised additive model (GAM) analysis. The daily maximum 8-h moving average O-3 concentrations were considered in these statistical models (dependent variable). MLR models indicated that meteorology and precursor species concentrations are able to explain similar to 50% of the variability in daily maximum O-3 levels. MLR analysis revealed that atmospheric carbon monoxide (CO), temperature and relative humidity were the strongest factors affecting the daily O-3 variability. In summer, daily O-3 variances were mostly associated with relative humidity, while winter O-3 levels were mostly linked to temperature and CO. PCA indicated that CO, temperature and relative humidity were not strongly collinear. GAM also identified CO, temperature and relative humidity as the strongest factors affecting the daily variation of O-3. Partial residual plots found that temperature, radiation and nitrogen oxides most likely have a non-linear relationship with O-3,while the relationship with relative humidity and CO is probably linear. An inter-comparison between O-3 levels modelled with the three statistical models compared to measured O-3 concentrations showed that the GAM model offered a slight improvement over the MLR model. These findings emphasise the critical role of regional-scale O-3 precursors coupled with meteorological conditions in daily variances of O-3 levels in continental South Africa.Peer reviewe

Captures d'écran : la photographie de presse et l'image télévisée

Influenza-associated disease burden among children in tropical sub-Saharan Africa is not well established, particularly outside of the 2009 pandemic period. We estimated the burden of influenza in children aged 0-4 years through population-based surveillance for influenza-like illness (ILI) and acute lower respiratory tract illness (ALRI). Household members meeting ILI or ALRI case definitions were referred to health facilities for evaluation and collection of nasopharyngeal and oropharyngeal swabs for influenza testing by real-time reverse transcription polymerase chain reaction. Estimates were adjusted for health-seeking behavior and those with ILI and ALRI who were not tested. During 2008-2012, there were 9,652 person-years of surveillance among children aged 0-4 years. The average adjusted rate of influenza-associated hospitalization was 4.3 (95% CI 3.0-6.0) per 1,000 person-years in children aged 0-4 years. Hospitalization rates were highest in the 0-5 month and 6-23 month age groups, at 7.6 (95% CI 3.2-18.2) and 8.4 (95% CI 5.4-13.0) per 1,000 person-years, respectively. The average adjusted rate of influenza-associated medically attended (inpatient or outpatient) ALRI in children aged 0-4 years was 17.4 (95% CI 14.2-19.7) per 1,000 person-years. Few children who had severe laboratory-confirmed influenza were clinically diagnosed with influenza by the treating clinician in the inpatient (0/33, 0%) or outpatient (1/109, 0.9%) settings. Influenza-associated hospitalization rates from 2008-2012 were 5-10 times higher than contemporaneous U.S. estimates. Many children with danger signs were not hospitalized; thus, influenza-associated severe disease rates in Kenyan children are likely higher than hospital-based estimates suggest

Plasma proteomic patterns show sex differences in early concentric left ventricular remodeling

BACKGROUND: Concentric remodeling (cRM) can precede heart failure with preserved ejection fraction (HFpEF), a condition prevalent in women. METHODS: Patients (n=60 593, 54.2% women) visiting outpatient clinics of Cardiology Centers of the Netherlands were analyzed for cRM, HFpEF development, and mortality risk. We studied risk factors for relative wall thickness both sex-stratified and in women and men combined. Biomarker profiling was performed (4534 plasma proteins) in a substudy involving 557 patients (65.4% women) to identify pathways involved in cRM. RESULTS: cRM was present in 23.5% of women and 27.6% of men and associated with developing HFpEF (HR, 2.15 [95% CI, 1.51-2.99]) and mortality risk (HR, 1.09 [95% CI, 1.00-1.19]) in both sexes. Age, heart rate, and hypertension were statistically significantly stronger risk factors for relative wall thickness in women than men. Higher circulating levels of IFNA5 (interferon alpha-5) were associated with higher relative wall thickness in women only. Pathway analysis revealed differential pathway activation by sex and increased expression of inflammatory pathways in women. CONCLUSIONS: cRM is prevalent in approximately 1 in 4 women and men visiting outpatient cardiology clinics and associated with HFpEF development and mortality risk in both sexes. Known risk factors for cRM were more strongly associated in women than men. Proteomic analysis revealed inflammatory pathway activation in women, with a central role for IFNA5. Differential biologic pathway activation by sex in cRM may contribute to the female predominance of HFpEF and holds promise for identification of new therapeutic avenues for prevention and treatment of HFpEF. REGISTRATION: URL: https://www. CLINICALTRIALS: gov; Unique identifier: NCT001747

Identifying plasma proteomic signatures from health to heart failure, across the ejection fraction spectrum

Circulating proteins may provide insights into the varying biological mechanisms involved in heart failure (HF) with preserved ejection fraction (HFpEF) and reduced ejection fraction (HFrEF). We aimed to identify specific proteomic patterns for HF, by comparing proteomic profiles across the ejection fraction spectrum. We investigated 4210 circulating proteins in 739 patients with normal (Stage A/Healthy) or elevated (Stage B) filling pressures, HFpEF, or ischemic HFrEF (iHFrEF). We found 2122 differentially expressed proteins between iHFrEF-Stage A/Healthy, 1462 between iHFrEF-HFpEF and 52 between HFpEF-Stage A/Healthy. Of these 52 proteins, 50 were also found in iHFrEF vs. Stage A/Healthy, leaving SLITRK6 and NELL2 expressed in lower levels only in HFpEF. Moreover, 108 proteins, linked to regulation of cell fate commitment, differed only between iHFrEF-HFpEF. Proteomics across the HF spectrum reveals overlap in differentially expressed proteins compared to stage A/Healthy. Multiple proteins are unique for distinguishing iHFrEF from HFpEF, supporting the capacity of proteomics to discern between these conditions.</p

The Logic of the ‘As If’ and the Existence of God: An Inquiry into the Nature of Belief in the Work of Jacques Derrida

The religious thematics at play in the work of Jacques Derrida have often provided an ongoing platform from which to struggle with the entire scope of his work, thus moving the seemingly peripheral discourses on religion within his oeuvre to the center stage. Despite repeated attempts to come to terms both theologically and philosophically with the conditional nature of representations, the problematics of representation are perhaps nowhere more forcefully demonstrated than in the work of Derrida. Indeed, for Derrida, the ‘as if’, as a regulative principle directly appropriated and modified from its Kantian context, becomes the central lynchpin for understanding, not only Derrida’s philosophical system as a whole, but also his numerous seemingly enigmatic references to his ‘jewishness’, as I intend to demonstrate in what follows. Through an analysis of the function of the ‘as if’ within the history of thought, from Greek tragedy to the poetry of Wallace Stevens, I hope to show how Derrida can only appropriate his Judaic roots as an act of mourning that seeks to render the lost object as present, ‘as if’ it were incorporated by the subject for whom this act nevertheless remains an impossibility. As Derrida discerns within the poetry of Paul Celan, bringing a sense of presence/presentness to our experiences, and as a confirmation of the subject which the human being struggles to assert, is the poetic task par excellence. It is seemingly also, if Derrida is to be understood on this point, the only option left to a humanity wherein poetry comes to express what religious formulations can no longer justify

Plasma Proteomic Patterns Show Sex Differences in Early Concentric Left Ventricular Remodeling

BACKGROUND: Concentric remodeling (cRM) can precede heart failure with preserved ejection fraction (HFpEF), a condition prevalent in women. METHODS: Patients (n=60 593, 54.2% women) visiting outpatient clinics of Cardiology Centers of the Netherlands were analyzed for cRM, HFpEF development, and mortality risk. We studied risk factors for relative wall thickness both sex-stratified and in women and men combined. Biomarker profiling was performed (4534 plasma proteins) in a substudy involving 557 patients (65.4% women) to identify pathways involved in cRM. RESULTS: cRM was present in 23.5% of women and 27.6% of men and associated with developing HFpEF (HR, 2.15 [95% CI, 1.51-2.99]) and mortality risk (HR, 1.09 [95% CI, 1.00-1.19]) in both sexes. Age, heart rate, and hypertension were statistically significantly stronger risk factors for relative wall thickness in women than men. Higher circulating levels of IFNA5 (interferon alpha-5) were associated with higher relative wall thickness in women only. Pathway analysis revealed differential pathway activation by sex and increased expression of inflammatory pathways in women. CONCLUSIONS: cRM is prevalent in approximately 1 in 4 women and men visiting outpatient cardiology clinics and associated with HFpEF development and mortality risk in both sexes. Known risk factors for cRM were more strongly associated in women than men. Proteomic analysis revealed inflammatory pathway activation in women, with a central role for IFNA5. Differential biologic pathway activation by sex in cRM may contribute to the female predominance of HFpEF and holds promise for identification of new therapeutic avenues for prevention and treatment of HFpEF. REGISTRATION: URL: https://www. CLINICALTRIALS: gov; Unique identifier: NCT001747