The Ursinus Weekly, October 8, 1962

Agnosticism on the college campus theme of YM-YWCA\u27s Fall retreat • Football victory highlights second annual Parents Day • Social frats name queens • Student teachers assume duties • Dr. Miller scheduled to speak on India at Forum Wednesday • Whatley hosts dinner for campus leaders • Mr. and Mrs. North selected as Curtain Club Fall production • Religious convocation next week • Navy information team visits campus Thursday • Applications available for Fulbright grants • Math Club picnic opens year\u27s activities • Semester films top-rate • Pre-medical meeting to feature students • Manser named treasurer for sophomore class • Editorial: The MSGA and the faculty; It\u27s not our fault • Avant-garde play seen last Summer • Deeply creative scientific mind, candid manner mark Dr. Staiger • Letters to the editor • UC coed continues tale of Summer at Indian reservation school • Bears down Hopkins 20-12 • Player of the week: Rhile a keystone in Bears line • Ursinus coed lacrosse standout • Next week\u27s opponent: Wilkes; Homecoming opponent: Swarthmore • Soccermen face 10 game schedule • Greek gleanings • Town police chief in Evening Schoolhttps://digitalcommons.ursinus.edu/weekly/1277/thumbnail.jp

Comprehensive molecular characterization of urothelial bladder carcinoma

Urothelial carcinoma of the bladder is a common malignancy that causes approximately 150,000 deaths per year worldwide. So far, no molecularly targeted agents have been approved for treatment of the disease. As part of The Cancer Genome Atlas project, we report here an integrated analysis of 131 urothelial carcinomasto provide a comprehensive landscape of molecular alterations. There were statistically significant recurrent mutations in 32 genes, including multiple genes involved in cell-cycle regulation, chromatin regulation, and kinase signalling pathways, as well as 9 genes not previously reported as significantly mutated in any cancer. RNA sequencing revealed four expression subtypes, two of which (papillary-like and basal/squamous-like) were also evident in microRNA sequencing and protein data. Whole-genome and RNA sequencing identified recurrent in-frame activating FGFR3-TACC3 fusions and expression or integration of several viruses (including HPV16) that are associated with gene inactivation. Our analyses identified potential therapeutic targets in 69% of the tumours, including 42% with targets in the phosphatidylinositol-3-OH kinase/AKT/mTOR pathway and 45% with targets (including ERBB2) in the RTK/MAPK pathway. Chromatin regulatory genes were more frequently mutated in urothelial carcinoma than in any other common cancer studied so far, indicating the future possibility of targeted therapy for chromatin abnormalitiesclose27