SLIDES: Tug Hill Commission, NY

Presenter: Linda Gibbs, Natural Resources Specialist, Tug Hill Commission, NY 26 slide

Confidential Memorandum from Linda Gibbs Re: Summary of the Private Hearing on Ethics

This document is a summary of the September 22, 1987 private New York City Charter Revision Commission hearing on ethics. The memorandum was written by Linda Gibbs and it is dated September 29, 1987. This document along with several others were originally contained in a binder labeled, Materials re: First Private Hearing (Ethics)

SLIDES: Tug Hill Commission, NY

Presenter: Linda Gibbs, Natural Resources Specialist, Tug Hill Commission, NY 26 slide

Robert Henri and Cosmopolitan Culture of Fin-de-Siecle France

The American painter Robert Henri (1865–1929) lived in Paris and its environs for nearly eight years between 1888–1900. This dissertation relates the critical impact his extensive exposure to fin-de-siecle French culture had upon his early paintings, his theories about the production of art, and ultimately upon the ideological foundation of the Ashcan School. This is accomplished through analysis of the many significant cosmopolitan elements Henri encountered in France not only in the realm of art but literature, philosophy, and politics. Henri\u27s rebellion against the art institutional bureaucracy and hierarchy and his non-traditional teaching methods have frequently been attributed to the individualist spirit of the American frontier where he spent much of his youth. Such stereotyping diminishes the importance of his residencies in France. In the Introduction, these persistent references to Henri\u27s western upbringing are chronologically surveyed. The nationalist context in which he has so often been placed and his alignment with primarily American writers, artists, and thinkers is also called into question. Part I of the dissertation begins with a chapter on Henri\u27s early studies at the Pennsylvania Academy of Fine Arts and surveys the degree to which that training influenced his theories and style. The subsequent three chapters chronicle his first trip to France from 1888–1891 in terms of the literature he read and the many parallels that exist between such diverse sources as Emile Zola and Leo Tolstoy and his own evolving attitudes about art. Part II begins with a chapter on French politics and its influence on Henri, with an emphasis on the anarchist movement. The following chapter charts the similarities between the anti-positivism of Henri\u27s art theories found in his treatise The Art Spirit and the theory of vitalism developed by the French philosopher Henri Bergson. The final chapter surveys early critical reaction to Henri\u27s early paintings and analyzes these works in terms of the many influences discussed throughout the dissertation. The conclusion assesses the impact of Henri\u27s French experience on the philosophical development of the Ashcan School and establishes his importance as a vanguard of complex modern thought in turn-of-the-century American

The making of anti-nuclear Scotland: activism, coalition building, energy politics and nationhood, c.1954-2008

This article contributes to understanding how civil nuclear power shaped post-war British history through studying opposition to nuclear energy in Scotland. Over the second half of the twentieth century, pessimistic assessments challenged the optimism that had developed during the 1950s. Under devolution, Scottish administrations have used planning policies to block future nuclear generating plants, institutionalising a marked distinction with the rest of the UK. The origins of these differences are traced to anti-nuclear protests and the growth of a social movement coalition that linked anti-nuclear activism with growing public sentiment and electoral politics, particularly through the Scottish National Party (SNP). Reflections from oral history interviews are used to examine diverse local protest contexts supplemented by archives from the anti-nuclear movement and the SNP. During the 1970s, protests against Torness power station in East Lothian and the drilling of test bores for waste disposal in South Ayrshire were given a national orientation by SNP politicians. Over the course of the 1980s, the anti-nuclear coalition broadened through growing opposition to Torness and in response to the Chernobyl disaster. These changes encouraged a lasting symbiosis between pro-devolution and anti-nuclear sentiments which were subsequently embodied in policies pursued by devolved administrations during the 2000s

Human immortalized chondrocytes carrying heterozygous FGFR3 mutations: An in vitro model to study chondrodysplasias

AbstractAchondroplasia and thanatophoric dysplasia are human chondrodysplasias caused by mutations in the fibroblast growth factor receptor 3 (FGFR3) gene. We have developed an immortalized human chondrocyte culture model to study the regulation of chondrocyte functions. One control and eight mutant chondrocytic lines expressing different FGFR3 heterozygous mutations were obtained. FGFR3 signaling pathways were modified in the mutant lines as revealed by the constitutive activation of the STAT pathway and an increased level of P21WAF1/CIP1 protein. This model will be useful for the study of FGFR3 function in cartilage studies and future therapeutic approaches in chondrodysplasias

The cloning, genomic organization and tissue expression profile of the human DLG5 gene

BACKGROUND: Familial atrial fibrillation, an autosomal dominant disease, was previously mapped to chromosome 10q22. One of the genes mapped to the 10q22 region is DLG5, a member of the MAGUKs (Membrane Associated Gyanylate Kinase) family which mediates intracellular signaling. Only a partial cDNA was available for DLG5. To exclude potential disease inducing mutations, it was necessary to obtain a complete cDNA and genomic sequence of the gene. METHODS: The Northern Blot analysis performed using 3' UTR of this gene indicated the transcript size to be about 7.2 KB. Using race technique and library screening the entire cDNA was cloned. This gene was evaluated by sequencing the coding region and splice functions in normal and affected family members with familial atrial fibrillation. Furthermore, haploid cell lines from affected patients were generated and analyzed for deletions that may have been missed by PCR. RESULTS: We identified two distinct alternately spliced transcripts of this gene. The genomic sequence of the DLG5 gene spanned 79 KB with 32 exons and was shown to have ubiquitous human tissue expression including placenta, heart, skeletal muscle, liver and pancreas. CONCLUSIONS: The entire cDNA of DLG5 was identified, sequenced and its genomic organization determined

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