56 research outputs found

    PRIVATE SECTOR AGRICULTURAL TENANCY ARRANGEMENTS IN EUROPE: THEMES AND DIMENSIONS; A CRITICAL REVIEW OF CURRENT LITERATURE

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    Although there is widespread support for the "ideal model" of agricultural production being based around the owner-occupier farmer, it is recognized that, for a variety of reasons, this ideal is neither always attainable nor desirable. There is also a need to ensure that farming becomes competitive when exposed fully to world markets. This means that farmers are likely to require the flexibility to expand their businesses in circumstances where they may not have the capital to purchase the additional assets. The need to find suitable systems for agricultural tenancy reform remains paramount as a means both for sustaining rural communities generally and for establishing mechanisms suitable for matching the demand for and supply of private land for rent. The United Nations Food and Agriculture Organization (FAO) recently commissioned a study of agricultural land tenure systems in order to identify elements of good practice in existing arrangements for the leasing of private sector agricultural land. This report is confined to a consideration of and commentary on the existing literature on tenure and tenancy arrangements as a basis for identifying examples of good practice. For the purposes of establishing good practice, this report concentrates on the market economies of northern and western Europe, predominantly the fifteen current member states of the European Union, while being aware of the principal dimensions of land reform in central and eastern European and former Soviet Union countries.Farm tenancy--Europe, Farm tenancy--Europe--Bibliography, Farm tenancy--Government policy--Europe, Land tenure--Europe, Land Economics/Use,

    Intellectual enrichment and genetic modifiers of cognition and brain volume in Huntington's disease

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    An important step towards the development of treatments for cognitive impairment in ageing and neurodegenerative diseases is to identify genetic and environmental modifiers of cognitive function and understand the mechanism by which they exert an effect. In Huntington’s disease, the most common autosomal dominant dementia, a small number of studies have identified intellectual enrichment, i.e. a cognitively stimulating lifestyle and genetic polymorphisms as potential modifiers of cognitive function. The aim of our study was to further investigate the relationship and interaction between genetic factors and intellectual enrichment on cognitive function and brain atrophy in Huntington’s disease. For this purpose, we analysed data from Track-HD, a multi-centre longitudinal study in Huntington’s disease gene carriers and focused on the role of intellectual enrichment (estimated at baseline) and the genes FAN1, MSH3, BDNF, COMT and MAPT in predicting cognitive decline and brain atrophy. We found that carrying the 3a allele in the MSH3 gene had a positive effect on global cognitive function and brain atrophy in multiple cortical regions, such that 3a allele carriers had a slower rate of cognitive decline and atrophy compared with non-carriers, in agreement with its role in somatic instability. No other genetic predictor had a significant effect on cognitive function and the effect of MSH3 was independent of intellectual enrichment. Intellectual enrichment also had a positive effect on cognitive function; participants with higher intellectual enrichment, i.e. those who were better educated, had higher verbal intelligence and performed an occupation that was intellectually engaging, had better cognitive function overall, in agreement with previous studies in Huntington’s disease and other dementias. We also found that intellectual enrichment interacted with the BDNF gene, such that the positive effect of intellectual enrichment was greater in Met66 allele carriers than non-carriers. A similar relationship was also identified for changes in whole brain and caudate volume; the positive effect of intellectual enrichment was greater for Met66 allele carriers, rather than for non-carriers. In summary, our study provides additional evidence for the beneficial role of intellectual enrichment and carrying the 3a allele in MSH3 in cognitive function in Huntington’s disease and their effect on brain structure
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