Synthesis, physical properties, antimicrobial potentials of some mixed antibiotics complexed with transition metals and their effects on alkaline phosphatase activities of selected rat tissues

Mixed ligand metal complexes of chloramphenicol and oxytetracycline were prepared by using Ni(II), Co(II) and Fe(III) metal chloride hexahydrate. They were characterized based on some physical technique and spectroscopic analysis such as AAS, UV, and IR spectroscopy. Based on the analytical and spectroscopic data, the complexes were proposed to have the formulae [ML1L2](Cl)n (where M = Ni(II), Co(II), Fe(III); L1 = chloramphenicol, L2 = oxytetracycline and n = 2 - 3). IR spectra suggested that both L1 and L2 coordinated to the metal ions in a terdentate manner with �(O-H), �(C=O) and �(N-H) as donor sites in each of the ligands. The complexes were proposed to be of octahedral. The synthesized complexes, in compares to their ligands, were screened for their antibacterial activity against isolated strains of Escherichia coli, Staphylococcus aureus and Klebsiella pneumonia by using diffusion method. The activity data showed the metal complexes to be more potent antibacterial than the parent drugs against the three species. Toxicology tests against some tissues of albino rat (Rattus novergicuss) revealed toxicity of the complexes as compared to the parent drugs. Ni(II) complex was found to possess no significant difference (P > 0.05) in alkaline phosphatase from both homogenates of liver and kidney and rat serum. However, Co(II) and Fe(III) complexes were found to significantly increase (P < 0.05) alkaline phosphatase from homogenates of liver and kidney tissues of the tested doses but there was no significant difference (P > 0.05) in alkaline phosphatase from rat serum

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Complex safety-critical Cyber-Physical Systems require modern approaches that can provide evidence of their correct functioning. Among the many state-of-the-art approaches is runtime verification, which constantly verifies if a system’s behavior complies with its specification. However, the coupling of monitors causes an inevitable overhead that could compromise the system’s safety. We present the concept of a framework capable of analyzing the schedulability of a set of mode-change supporting Cyber-Physical Systems in the presence of coupled runtime monitors.N/

Synthesis, characterization, antimicrobial activity and toxicology study of some metal complexes of mixed antibiotics

Mixed ligand metal complexes of ampicillin and chloramphenicol prepared by using Ni(II), Co(II) and Fe(III) metal chloride hexahydrate were reported and characterized based on some physical properties and spectroscopic analysis such as AAS, UV, and IR spectroscopy. The complexes were proposed to have the formulae [ML1L2](Cl)n ( where M= Ni(II), Co(II), Fe(III); L1 = ampicillin, L2 = chloramphenicol, and n=2-3). IR spectra suggested that both L1 and L2 coordinated to the metal ions in a terdentate manner with �(O-H), �(C=O) and �(N-H) as donor sites in each of the ligands. From analytical and spectroscopic data obtained, the complexes were proposed to be of octahedral. The synthesized complexes, in compares to their ligands, were also screened for their antibacterial activity against isolated strains of Escherichia coli, Staphylococcus aureus and Klebsiella pneumonia by using agar diffusion method. The activity data showed the metal complexes to be more potent antibacterial than the parent drugs against the three bacteria species. However, toxicology tests against some tissues of albino rat (Rattus novergicuss) revealed toxicity of the complexes as compared to the parent drugs because the complexes were found to significantly increase (P<0.05) alkaline phosphatase from homogenates of liver and kidney tissues of the tested doses. However, there was no significant difference (P>0.05) in ALP of rat serum. The results generally indicated that more potent compounds with better physical properties and enhanced antimicrobial activities upon complexation have been prepared

Levi Pennington Writing to Lester Haworth, January 7, 1947

Levi Pennington writing to Lester Haworth about his work for Heifers for Relief and about some of the issues at Pacific College in the wake of Gulley\u27s resignation.https://digitalcommons.georgefox.edu/levi_pennington/1117/thumbnail.jp

Towards the design of a DSL to enable the secure Runtime Monitoring and Verification of Safety-Critical CPS

3rd Doctoral Congress in Engineering will be held at FEUP on the 27th to 28th of June, 2019Safety-critical systems commonly face unpredictable and hostile environments, with emergent behaviors and with a growing number of external, malicious attackers. These are risk factors that should be taken into account during these systems design phases, but that is not always possible due to the overall complexity of the interaction between the systems and its external operational environment. Cyber-Physical Systems (CPS) are notable examples of practical implementations of safety-critical systems. Being able to guarantee that safetycritical CPS do not fail upon operation can easily become a huge challenge, depending on how complex the system is. Among the most promising approaches to reduce the complexity of designing safety-critical CPS are Runtime Monitoring (RM) (Watterson and Heffernan 2017) and Runtime Verification (RV) (Bartocci Et al. 2018), where monitors are generated and orchestrated in a software architecture that can be coupled to the target system, observe it during its execution, and identify aspects that were not foreseen during design phase, or that could not be proved to be absent via static verification methods. Monitors can be used to verify the correct functioning of a system by analyzing direct (and/or indirect) aspects of it. This can be especially useful when considering a security-oriented point of view, where monitors can identify possible security attacks to a system when exposed to the events taking place or the patterns of data being processed.info:eu-repo/semantics/publishedVersio

Spartan Daily, January 17, 1936

Volume 24, Issue 62https://scholarworks.sjsu.edu/spartandaily/2390/thumbnail.jp

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This work discusses the ongoing development of a toolset named MARS aimed to ease the process of safely deploying runtime verification monitors into distributed micro-ROS and ROS2 nodes. The work is motivated by a use case in the health and automotive domains and covers safety/security concerns around the manipulation of sensitive biometric data.This work was partially supported by National Funds through FCT/MCTES (Portuguese Foundation for Science and Technology), within the CISTER Research Unit (UIDP/UIDB/04234/2020); also by FCT within project ECSEL/0016/2019 and from the ECSEL Joint Undertaking (JU) under grant agreement No 876852. The JU receives support from the European Union’s Horizon 2020 research and innovation programme and Austria, Czech Republic, Germany, Ireland, Italy, Portugal, Spain, Sweden, Turkey. We would also like to thank Antonio Rodriguez and Pablo Garrido from eProsima for their collaboration in development of the secure custom transport layer of MARS. Disclaimer: This document reflects only the author’s view and the Commission is not responsible for any use that may be made of the information it contains)info:eu-repo/semantics/publishedVersio

Spartan Daily, January 17, 1936

Volume 24, Issue 62https://scholarworks.sjsu.edu/spartandaily/2390/thumbnail.jp