Angiogenic and Neurotrophic Effects of Human Bone Marrow Mesenchymal Stem Cell-Derived Conditioned Medium for Erectile Dysfunction

Department of Biomedical EngineeringA three-dimensional spheroid culture system to harvest conditioned medium (CM) from human bone marrow-derived mesenchymal stem cells (hBM-MSCs) with high efficiency were introduced and investigated the therapeutic effects of hBM-MSC-CM on erectile dysfunction (ED). In order to harvest CM with higher protein concentration than CM harvested by conventional method in 2D culture system, a variable parameter study considering the culture conditions such as spheroid diameter and centrifugation time was performed. As a result, it was confirmed that CM harvested from 3D spheroid culture system had much more proteins than those cultured in 2D environment. In addition, the total protein concentration in CM increased in proportion to the centrifugation time using a centrifugal filter. Additionally, ELISA and secretome assay showed that CM contained growth factors that help in angiogenesis such as angiogenin (ANG) and vascular endothelial growth factor (VEGF), and in nerve regeneration like glial cell-derived neurotrophic factor (GDNF), nerve growth factor (NGF), and brain-derived neurotrophic factor (BDNF). Also, it was identified that angiogenic effects of CM contributing to tube, node and mesh formation of endothelial cells was proportional to the concentration of CM in vitro tube formation assay. Then, histomorphometric studies such as immunohistochemistry and immunofluorescence were performed using the cavernous nerve (CN) injury rat model. In result, histomorphometric analysis showed that neural regeneration and vascular regeneration increased along with CM concentration. To sum up, we established an efficient method to obtain hBM-MSC-CM containing high concentration of growth factors, which is expected to be one of the promising methods of regenerative medicine for treating ED disease.clos

The Use of Pivot Point in Ship Handling for Safer and More Accurate Ship Manoeuvring

The size of ships has increased notably over recent decades. The size of harbours and ports has however not grown in proportion. As a result ship manoeuvring in harbours and ports has become more problematic, and more of an art than a science. The ‘pivot point’ concept can be useful in analysing slow ship manoeuvring and has therefore been widely adopted by practitioners and training institutions. As a result many practitioners now routinely plan con-fined manoeuvring using the ‘pivot point’ concept. Traditionally the ‘pivot point’ concept has been defined in a number of contradictory and inaccurate ways leading to confusion and mystification. As a result many practitioners and trainers often rely on intuition to bridge the gap between reality and their flawed understanding of theory. In this presentation the theoretical aspect of the pivot point is reviewed and correct definitions put forward and applied to basic and ‘special’ ship’s manoeuvres

The “Singapore Model” in Gaming: Applications in South Korea

The gaming governance system in Singapore is a very well-known and internationally renowned model. Singapore began to launch their gaming regulation system in 2005 by establishing a national framework on gambling prior to opening two integrated resorts in the country in 2010 (Winslow, Cheok, & Subramaniam, 2015). In contrast, the South Korean “model” is much less renowned. Though there have been discussions about introducing full-scale integrated resorts, the government currently allows South Korean citizens to gamble in only one property - Kangwon Land (Research, 2016). However, Kangwon Land’s situation is controversial in South Korea, with concerns about problem gambling issues arising from the very beginning. The gambling addiction rate of South Korea in 2012 study conducted by National Gaming Control Commission, was 6.1%, which was significantly higher than that of Singapore which was only 0.2% in 2014 (though it should be noted, measurement differences are common in this field). This gambling addiction rate also appears to be high compared to some other countries such as the U.K. (2.5%), Australia (2.4%), and France (1.3%) (The Chosunilbo, 2012)

Technology innovation & green policy in Korea

The new growth engine in the 21stcentury depends on an innovative system to create, distribute and apply knowledge to industrialization processes. The industrial technology has been developed rapidly with the progress of knowledge based information in the last decade. In this point of view a cooperative partnership between industry and academy becomes much more important and necessary. Strategically fostering such cooperations and promoting rapid technology development have been reached with industrial clusterization in the last 20 years in Korea. --

Production and decay of a heavy radion in Randall-Sundrum model at the LHC

We study production and decay of a radion predicted in the Randall-Sundrum model at the LHC. The radion is a scalar particle and its production and decay channels are quite similar to those of the Higgs boson. We find constraints on the model parameter space taking account of the results of the Higgs boson search at the LHC. We also study a possibility discriminating the radion from the scalar particles in the other model such as the supersymmetric standard model at the LHC experiments.Comment: 3 pages, 3 figures. Proceedings of Hadron Collider Physics Symposium 2012, Typos correcte

Production and decay of radion in Randall-Sundrum model at a photon collider

A warped extra dimension model predicts an extra scalar particle beyond the Standard Model which is called a radion. Although interactions of the radion are similar to those of the Higgs boson in the Standard Model, a relatively light radion ($\lesssim 100 {\rm GeV}$) is not severely constrained from the Higgs search experiments at the LHC. In this paper we study discovery potential of the radion at a photon collider as an option of ILC. Owing to the trace anomaly of the energy-momentum tensor, both a production of radion in $\gamma \gamma$ collision and its decay to gluon pair are enhanced sizably. We find that the photon collider has a sensitivity for discovering the radion in low-mass region up to $\Lambda_\phi\sim 3 {\rm TeV}$, where $\Lambda_\phi$ is a scale parameter which suppresses the interactions of radion to the Standard Model particles.Comment: 13pages, 6figures. v2:References added. Fig.2 and text, modifie