821 research outputs found
Dragging mesons by hot hadrons
We evaluate the drag and diffusion coefficients of a hot hadronic medium
consisting of pions, nucleons, kaons and eta using open charm mesons as a
probe. The interaction of the probe with the hadronic matter has been treated
in the framework of effective field theory. It is observed that the magnitude
of both the transport coefficients are significant, indicating substantial
amount of interaction of the heavy mesons with the thermal hadronic system. The
results may have noticeable impact on the experimental observable like the
suppression of single electron spectra originating form the decays of heavy
mesons in nuclear collisions at relativistic energies.Comment: One Latex and three eps files, form factor effects include
Little Higgs after the little one
At the LHC, the Littlest Higgs Model with -parity is characterised by
various production channels. If the -odd quarks are heavier than the exotic
partners of the and the , then associated production can be as important
as the pair-production of the former. Studying both, we look for final states
comprising at least one lepton, jets and missing transverse energy. We consider
all the SM processes that could conspire to contribute as background to our
signals, and perform a full detector level simulation of the signal and
background to estimate the discovery potential at the current run as well as at
the scheduled upgrade of the LHC. We also show that, for one of the channels,
the reconstruction of two tagged -jets at the Higgs mass provides us with an unambiguous hint for this model.Comment: 22 pages, 3 captioned figures, 8 Tables; minor modifications, version
published in JHE
DESIGN, OPTIMISATION AND EVALUATION OF PIROXICAM FAST DISSOLVING TABLETS EMPLOYING STARCH TARTRATE-A NEW SUPERDISINTEGRANT
Objective: To enhance the solubility of poorly soluble drugs by evaluating starch tartrate as a superdisintegrant in the formulation of fast dissolving tablets by employing 23 factorial design.
Methods: Starch tartrate was synthesized by gelatinization process. The physical and micromeritic properties were performed to evaluate the synthesized starch tartrate. The fast dissolving tablets of piroxicam were prepared by using starch tartrate as a superdisintegrant in different proportions by direct compression technique using 23 factorial design. The drug content, hardness, friability, disintegration time and other dissolution characteristics like percent dissolved in 5 min (PD5), dissolution efficiency in 5 min (DE5%) and first-order rate constant (K1) were used in the evaluation of prepared fast dissolving tablets.
Results: The superdisintegrant starch tartrate prepared was found to be fine, free-flowing slightly crystalline powder. Starch tartrate exhibited good swelling in water. The study between piroxicam and starch tartrate was shown the absence of interaction by fourier transform infrared spectra (FTIR) and differential scanning calorimetry (DSC). The drug content (99.83±0.56 %), hardness (3.7–3.9 kg/sq. Cm), and friability (0.12-0.15%) have been effective with regard to all the formulated fast dissolving tablets employing starch tartrate. The disintegration time of all the formulated fast dissolving tablets (FDTs) was found to be in the range of 12±0. 01 to 4500±0.02s. The optimized formulation F6 has the least disintegration time i.e., 12±0. 01s. The In vitro wetting time of the formulated tablets was found to be in the range of 35±0.09 to 1624±0.02s. The In–Vitro wetting time was less (i.e., 90s) in optimized formulation F6. The water absorption ratio of the formulated tablets was found to be in the range of 60±0.12 to 65±0.15%. The cumulative drug dissolved in the optimized formulation F6 was found to be 99.32±0.09% in 10 min.
Conclusion: The dissolution efficiency of piroxicam was enhanced when starch tartrate was found to be a superdisintegrant when combined with crospovidone and, hence it could be used in the formulation of fast dissolving tablets to provide immediate release of the contained drug within 10 min
Dark Matter and Collider Searches in -Symmetric 2HDM with Vector Like Leptons
We study the -symmetric two Higgs doublet model by adding two
generations of vector like leptons (VLL) which are odd under a discrete
symmetry. The lightest neutral component of the VLL acts as a dark matter (DM)
whereas the full VLL set belongs to a dark sector with no mixings allowed with
the standard model fermions. We analyse the model in light of dark matter and
collider searches. We show that the DM is compatible with the current relic
density data as well as satisfying all direct and indirect dark matter search
constraints. We choose some representative points in the model parameter space
allowed by all aforementioned dark matter constraints and present a detailed
collider analysis of multi-lepton signal viz. the mono-lepton, di-lepton,
tri-lepton and four-lepton along with missing transverse energy in the final
state using both the cut-based analysis and multivariate analysis respectively
at the high luminosity 14 TeV LHC run.Comment: 51 Pages, 10 Captioned figures and 20 Tables, minor changes made in
the manuscript, version accepted for publication in The European Physical
Journal C journa
Search for a leptophobic doubly charged Higgs in same-sign four-lepton and six-lepton signatures in a left-right symmetric model
We investigate the possibility of multi-lepton (four and six) signatures,
including an exotic signature of same-sign four-lepton (SS4L) as signals of
pair production of a doubly charged Higgs in the minimal left-right symmetric
model, extended with two doublet scalars. The right-handed neutrino masses are
generated in this model through a dimension- lepton-number violating
operator allowing the triplet scalar interactions with leptons to become
negligibly small. This leads to interesting six-lepton and SS4L signatures that
can be observed at the high-luminosity phase of the Large Hadron Collider
(HL-LHC) with almost no background for doubly charged Higgs with mass below 500
GeV.Comment: 32 pages, 8 figures, and 4 table
Search For a Leptoquark and Vector-like Lepton in a Muon Collider
The proposal for a high-energy muon collider offers many opportunities in the
search for physics beyond the Standard Model (BSM). The collider by
construction is likely to be more sensitive to the muon-philic models,
primarily motivated by the BSM explanation of muon excess and quark
flavor anomalies. In this work, we explore the potential of the proposed muon
collider in the context of such models and focus on one such model that extends
the Standard Model (SM) with a leptoquark, a vector-like lepton, and a real
scalar. In this model, we propose searches for TeV scale leptoquarks in
MET channel. Notably, the leptoquark can be produced singly at the
muon collider with a large cross-section. We have shown that a significant
signal in this channel can be detected at 3~TeV muon collider even with an
integrated luminosity as low as ~fb.Comment: 26 pages, 5 figures, and 3 table
A comparative study of drug prescribing indicators in various hospitals of West Bengal, India
Background: Rational use of drugs is essential to ensure safety and welfare of patients. Thus, prescription audits are conducted to monitor the practice of writing prescriptions. Various standard parameters have been rationalized by World Health Organization (WHO) in order to regulate drug utilization, globally. Present study aimed to compare the pattern of prescriptions generated in different healthcare centres of West Bengal.Methods: A cross-sectional study was conducted in the inpatient and outpatient departments of RG Kar Medical College, Kolkata, in order to evaluate the prescriptions. Literature was also surveyed with the keywords “prescription audit”, “West Bengal”, to extract data on prescription audits conducted in various other hospitals of West Bengal. The WHO prescribing indicators of all these health facilities were then compared to estimate the rationality of drug prescribed by different physicians.Results: Seven published reports of prescription audits were published from the period of 2013 to 2017, the distribution being- 2 health facilities from Kolkata, 2 from Burdwan, 1 each from Bankura, Murshidabad and North Bengal. WHO standards were not strictly followed by any of the hospitals. Polypharmacy level were higher in all the hospitals. Drugs were mostly prescribed from the essential medicine list (EML).Conclusions: Present study clearly indicated that it is essential to improve these parameters for most of the healthcare centres in order to prevent irrational use of drugs. Prescription audits should also be implemented regularly so that the patients can receive better treatment at minimum cost with suitable rational therapy
- …