Nicotinamide Riboside and the Aortic Response to Angiotensin II Infusion in Mice

Damage to vascular cells of the aorta drives vascular dysfunction and disease. Nicotinamide adenine dinucleotide (NAD+) is a cellular metabolite critical to cellular health, but NAD+ levels decline during oxidative insults and aging. The NAD+ precursor, nicotinamide riboside (NR) can augment NAD+ levels. Herein, I determined whether orally administrated NR could protect the aorta of middle-aged mice from acute and sustained angiotensin II (Ang II) infusion-induced damage. I demonstrate that orally administered NR can protect the aorta from damage imposed by Ang II